Incidental Mutation 'IGL03170:Olfr509'
ID411809
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr509
Ensembl Gene ENSMUSG00000049280
Gene Nameolfactory receptor 509
SynonymsGA_x6K02T2PBJ9-10976304-10975339, MOR267-14
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.064) question?
Stock #IGL03170
Quality Score
Status
Chromosome7
Chromosomal Location108644336-108651906 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 108646100 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 159 (I159V)
Ref Sequence ENSEMBL: ENSMUSP00000150157 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061690] [ENSMUST00000213756] [ENSMUST00000214861] [ENSMUST00000215075]
Predicted Effect probably benign
Transcript: ENSMUST00000061690
AA Change: I159V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000053819
Gene: ENSMUSG00000049280
AA Change: I159V

DomainStartEndE-ValueType
Pfam:7tm_4 29 305 1.8e-42 PFAM
Pfam:7tm_1 39 288 1.5e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213756
AA Change: I159V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000214861
AA Change: I159V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215075
AA Change: I159V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310035C23Rik C T 1: 105,735,955 T943I probably damaging Het
Cand2 A G 6: 115,797,900 D1023G probably damaging Het
Cyp2c54 A G 19: 40,072,365 probably null Het
Cyp4f37 C T 17: 32,625,119 probably benign Het
Cyr61 C A 3: 145,649,759 A12S probably benign Het
Entpd2 T C 2: 25,399,481 F325S probably damaging Het
Flnb T C 14: 7,818,261 I37T possibly damaging Het
Gm7030 C T 17: 36,128,713 G125E probably damaging Het
Gm7534 C T 4: 134,193,034 V607I possibly damaging Het
Gtpbp10 A G 5: 5,555,355 V116A probably benign Het
Lrp1b T A 2: 40,697,444 N164I unknown Het
Nle1 T A 11: 82,904,270 T312S probably benign Het
Pim1 T A 17: 29,491,178 L12Q possibly damaging Het
Plb1 G T 5: 32,284,902 C246F probably damaging Het
Ppp4r4 T C 12: 103,590,774 probably benign Het
Prl6a1 T A 13: 27,315,423 V63D possibly damaging Het
Ptprz1 G A 6: 22,959,767 A88T probably benign Het
Ranbp3l A T 15: 9,000,787 E31V probably damaging Het
Rgs9 G A 11: 109,259,855 T209I probably benign Het
Smg8 A G 11: 87,086,608 V49A probably damaging Het
Smim6 A T 11: 115,913,488 T34S possibly damaging Het
Snw1 T G 12: 87,472,252 T4P probably benign Het
Sod2 C A 17: 13,008,370 H70Q probably benign Het
Tro A G X: 150,655,560 S34P probably benign Het
Tshr T A 12: 91,537,869 M527K probably damaging Het
Uggt1 A C 1: 36,163,261 V1085G probably damaging Het
Vmn1r21 A G 6: 57,843,862 V199A probably damaging Het
Xkr9 T C 1: 13,700,812 I184T possibly damaging Het
Zfp369 T C 13: 65,294,410 S273P probably damaging Het
Other mutations in Olfr509
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Olfr509 APN 7 108645836 missense possibly damaging 0.47
IGL02015:Olfr509 APN 7 108646013 missense probably damaging 0.99
IGL02721:Olfr509 APN 7 108646375 nonsense probably null
R0746:Olfr509 UTSW 7 108646041 missense probably damaging 1.00
R0863:Olfr509 UTSW 7 108645658 missense probably benign 0.00
R1791:Olfr509 UTSW 7 108646364 missense probably benign 0.30
R4128:Olfr509 UTSW 7 108646426 missense probably benign 0.03
R5290:Olfr509 UTSW 7 108646548 missense probably benign
R5878:Olfr509 UTSW 7 108645739 missense probably damaging 1.00
R6030:Olfr509 UTSW 7 108646226 missense possibly damaging 0.87
R6030:Olfr509 UTSW 7 108646226 missense possibly damaging 0.87
R6545:Olfr509 UTSW 7 108646455 missense probably damaging 1.00
R7699:Olfr509 UTSW 7 108645672 missense probably damaging 1.00
R7700:Olfr509 UTSW 7 108645672 missense probably damaging 1.00
Z1176:Olfr509 UTSW 7 108645767 missense possibly damaging 0.88
Posted On2016-08-02