Incidental Mutation 'IGL03171:Zfp607b'
| ID |
411829 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp607b
|
| Ensembl Gene |
ENSMUSG00000057093 |
| Gene Name |
zinc finger protein 607B |
| Synonyms |
C030039L03Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
IGL03171
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
27388765-27405909 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 27393020 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 49
(N49K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112494
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000076421]
[ENSMUST00000120004]
|
| AlphaFold |
G3X9H3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000076421
AA Change: N49K
PolyPhen 2
Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000075755
Gene: ENSMUSG00000057093
AA Change: N49K
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
75 |
1.29e-35 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
1.08e-1 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
228 |
250 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
256 |
278 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
284 |
306 |
4.94e-5 |
SMART |
|
ZnF_C2H2
|
312 |
334 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
1.06e-4 |
SMART |
|
ZnF_C2H2
|
451 |
473 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
479 |
501 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
507 |
529 |
3.52e-1 |
SMART |
|
ZnF_C2H2
|
535 |
557 |
3.49e-5 |
SMART |
|
ZnF_C2H2
|
563 |
585 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
591 |
613 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
619 |
641 |
9.73e-4 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000120004
AA Change: N49K
PolyPhen 2
Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000112494
Gene: ENSMUSG00000057093
AA Change: N49K
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
14 |
75 |
1.29e-35 |
SMART |
|
ZnF_C2H2
|
172 |
194 |
1.08e-1 |
SMART |
|
ZnF_C2H2
|
200 |
222 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
228 |
250 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
256 |
278 |
1.69e-3 |
SMART |
|
ZnF_C2H2
|
284 |
306 |
4.94e-5 |
SMART |
|
ZnF_C2H2
|
312 |
334 |
2.36e-2 |
SMART |
|
ZnF_C2H2
|
339 |
361 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
367 |
389 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
395 |
417 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
423 |
445 |
1.06e-4 |
SMART |
|
ZnF_C2H2
|
451 |
473 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
479 |
501 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
507 |
529 |
3.52e-1 |
SMART |
|
ZnF_C2H2
|
535 |
557 |
3.49e-5 |
SMART |
|
ZnF_C2H2
|
563 |
585 |
1.56e-2 |
SMART |
|
ZnF_C2H2
|
591 |
613 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
619 |
641 |
9.73e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000124397
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127200
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 39 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700003E16Rik |
T |
A |
6: 83,139,377 (GRCm39) |
F434Y |
possibly damaging |
Het |
| Adam19 |
G |
T |
11: 46,029,681 (GRCm39) |
A709S |
probably damaging |
Het |
| Adgrf3 |
A |
T |
5: 30,401,292 (GRCm39) |
L42Q |
probably damaging |
Het |
| D430041D05Rik |
T |
C |
2: 104,071,508 (GRCm39) |
N1264S |
possibly damaging |
Het |
| Dnah9 |
T |
G |
11: 65,872,067 (GRCm39) |
K2721T |
probably benign |
Het |
| Efr3b |
C |
T |
12: 4,018,622 (GRCm39) |
A575T |
probably benign |
Het |
| Esco1 |
T |
C |
18: 10,594,263 (GRCm39) |
E341G |
probably damaging |
Het |
| Ezh2 |
G |
A |
6: 47,517,715 (GRCm39) |
R574* |
probably null |
Het |
| Fam169a |
G |
T |
13: 97,246,522 (GRCm39) |
|
probably benign |
Het |
| Fry |
T |
C |
5: 150,304,274 (GRCm39) |
Y555H |
probably damaging |
Het |
| Gm17175 |
A |
C |
14: 51,809,065 (GRCm39) |
S100R |
probably damaging |
Het |
| Gm527 |
T |
C |
12: 64,967,931 (GRCm39) |
Y118H |
probably damaging |
Het |
| H2-M10.4 |
G |
T |
17: 36,772,142 (GRCm39) |
T202N |
probably damaging |
Het |
| Ift70a1 |
C |
T |
2: 75,810,851 (GRCm39) |
A411T |
probably benign |
Het |
| Igf1 |
A |
T |
10: 87,700,683 (GRCm39) |
T36S |
probably damaging |
Het |
| Ints8 |
C |
T |
4: 11,231,702 (GRCm39) |
V428I |
probably benign |
Het |
| Itga6 |
G |
A |
2: 71,671,673 (GRCm39) |
|
probably null |
Het |
| Jmjd1c |
A |
G |
10: 67,061,277 (GRCm39) |
E1210G |
possibly damaging |
Het |
| Kdm2a |
A |
T |
19: 4,406,792 (GRCm39) |
V134E |
probably damaging |
Het |
| Limch1 |
C |
A |
5: 67,191,537 (GRCm39) |
N947K |
possibly damaging |
Het |
| Met |
T |
C |
6: 17,562,272 (GRCm39) |
|
probably benign |
Het |
| Neb |
A |
G |
2: 52,106,376 (GRCm39) |
|
probably benign |
Het |
| Ogg1 |
A |
G |
6: 113,310,375 (GRCm39) |
I274V |
possibly damaging |
Het |
| Ola1 |
A |
T |
2: 72,987,197 (GRCm39) |
I145K |
probably benign |
Het |
| Or2r11 |
G |
A |
6: 42,437,464 (GRCm39) |
T163I |
possibly damaging |
Het |
| Pacrg |
A |
G |
17: 10,795,462 (GRCm39) |
V166A |
possibly damaging |
Het |
| Pira2 |
T |
A |
7: 3,845,604 (GRCm39) |
E260V |
probably damaging |
Het |
| Prickle3 |
T |
C |
X: 7,531,526 (GRCm39) |
C277R |
probably damaging |
Het |
| Psen1 |
A |
G |
12: 83,761,638 (GRCm39) |
T147A |
probably damaging |
Het |
| Pxk |
C |
T |
14: 8,151,014 (GRCm38) |
|
probably benign |
Het |
| Scn11a |
G |
A |
9: 119,648,913 (GRCm39) |
P50L |
probably benign |
Het |
| Scn4a |
C |
A |
11: 106,236,418 (GRCm39) |
V281L |
probably benign |
Het |
| Shcbp1 |
A |
G |
8: 4,789,166 (GRCm39) |
I551T |
probably benign |
Het |
| Snx13 |
T |
A |
12: 35,150,539 (GRCm39) |
I281N |
probably benign |
Het |
| Spata31e4 |
T |
A |
13: 50,856,388 (GRCm39) |
S675R |
probably benign |
Het |
| Spopfm1 |
C |
A |
3: 94,173,762 (GRCm39) |
H257N |
probably benign |
Het |
| Tdo2 |
T |
C |
3: 81,874,336 (GRCm39) |
K209E |
probably benign |
Het |
| Trip6 |
C |
T |
5: 137,311,146 (GRCm39) |
R190Q |
probably benign |
Het |
| Ubqln1 |
T |
A |
13: 58,328,672 (GRCm39) |
E426D |
probably damaging |
Het |
|
| Other mutations in Zfp607b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02090:Zfp607b
|
APN |
7 |
27,398,140 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
IGL02114:Zfp607b
|
APN |
7 |
27,403,150 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL03329:Zfp607b
|
APN |
7 |
27,403,295 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0988:Zfp607b
|
UTSW |
7 |
27,402,401 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1518:Zfp607b
|
UTSW |
7 |
27,398,087 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1672:Zfp607b
|
UTSW |
7 |
27,391,948 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1733:Zfp607b
|
UTSW |
7 |
27,391,949 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1992:Zfp607b
|
UTSW |
7 |
27,401,949 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2849:Zfp607b
|
UTSW |
7 |
27,401,819 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3879:Zfp607b
|
UTSW |
7 |
27,403,476 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4117:Zfp607b
|
UTSW |
7 |
27,398,107 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4439:Zfp607b
|
UTSW |
7 |
27,402,149 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4610:Zfp607b
|
UTSW |
7 |
27,403,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4755:Zfp607b
|
UTSW |
7 |
27,402,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4909:Zfp607b
|
UTSW |
7 |
27,403,221 (GRCm39) |
missense |
probably benign |
|
|
R5095:Zfp607b
|
UTSW |
7 |
27,393,061 (GRCm39) |
intron |
probably benign |
|
|
R5301:Zfp607b
|
UTSW |
7 |
27,403,172 (GRCm39) |
missense |
probably benign |
|
|
R5422:Zfp607b
|
UTSW |
7 |
27,401,813 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5538:Zfp607b
|
UTSW |
7 |
27,402,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5546:Zfp607b
|
UTSW |
7 |
27,402,032 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5644:Zfp607b
|
UTSW |
7 |
27,403,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5649:Zfp607b
|
UTSW |
7 |
27,403,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5692:Zfp607b
|
UTSW |
7 |
27,402,889 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5945:Zfp607b
|
UTSW |
7 |
27,401,841 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6695:Zfp607b
|
UTSW |
7 |
27,403,464 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7402:Zfp607b
|
UTSW |
7 |
27,392,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7515:Zfp607b
|
UTSW |
7 |
27,402,921 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8402:Zfp607b
|
UTSW |
7 |
27,402,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8954:Zfp607b
|
UTSW |
7 |
27,403,387 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9494:Zfp607b
|
UTSW |
7 |
27,403,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9554:Zfp607b
|
UTSW |
7 |
27,402,464 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9727:Zfp607b
|
UTSW |
7 |
27,403,125 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Zfp607b
|
UTSW |
7 |
27,401,819 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation