Incidental Mutation 'IGL03171:Adgrf3'
ID411852
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Adgrf3
Ensembl Gene ENSMUSG00000067642
Gene Nameadhesion G protein-coupled receptor F3
SynonymsGpr113, LOC381628, PGR23
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL03171
Quality Score
Status
Chromosome5
Chromosomal Location30193431-30205722 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 30196294 bp
ZygosityHeterozygous
Amino Acid Change Leucine to Glutamine at position 42 (L42Q)
Ref Sequence ENSEMBL: ENSMUSP00000120958 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000088117] [ENSMUST00000125367]
Predicted Effect probably damaging
Transcript: ENSMUST00000088117
AA Change: L912Q

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000085440
Gene: ENSMUSG00000067642
AA Change: L912Q

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
low complexity region 85 97 N/A INTRINSIC
Blast:IG 163 252 2e-20 BLAST
Blast:CCP 341 399 1e-6 BLAST
low complexity region 403 415 N/A INTRINSIC
low complexity region 471 483 N/A INTRINSIC
GPS 632 684 2.68e-17 SMART
Pfam:7tm_2 687 935 1e-30 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000125367
AA Change: L42Q

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000120958
Gene: ENSMUSG00000067642
AA Change: L42Q

DomainStartEndE-ValueType
transmembrane domain 21 43 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003E16Rik T A 6: 83,162,395 F434Y possibly damaging Het
Adam19 G T 11: 46,138,854 A709S probably damaging Het
D430041D05Rik T C 2: 104,241,163 N1264S possibly damaging Het
Dnah9 T G 11: 65,981,241 K2721T probably benign Het
Efr3b C T 12: 3,968,622 A575T probably benign Het
Esco1 T C 18: 10,594,263 E341G probably damaging Het
Ezh2 G A 6: 47,540,781 R574* probably null Het
Fam169a G T 13: 97,110,014 probably benign Het
Fry T C 5: 150,380,809 Y555H probably damaging Het
Gm17175 A C 14: 51,571,608 S100R probably damaging Het
Gm4778 C A 3: 94,266,455 H257N probably benign Het
Gm527 T C 12: 64,921,157 Y118H probably damaging Het
Gm8765 T A 13: 50,702,352 S675R probably benign Het
H2-M10.4 G T 17: 36,461,250 T202N probably damaging Het
Igf1 A T 10: 87,864,821 T36S probably damaging Het
Ints8 C T 4: 11,231,702 V428I probably benign Het
Itga6 G A 2: 71,841,329 probably null Het
Jmjd1c A G 10: 67,225,498 E1210G possibly damaging Het
Kdm2a A T 19: 4,356,764 V134E probably damaging Het
Limch1 C A 5: 67,034,194 N947K possibly damaging Het
Met T C 6: 17,562,273 probably benign Het
Neb A G 2: 52,216,364 probably benign Het
Ogg1 A G 6: 113,333,414 I274V possibly damaging Het
Ola1 A T 2: 73,156,853 I145K probably benign Het
Olfr458 G A 6: 42,460,530 T163I possibly damaging Het
Pacrg A G 17: 10,576,533 V166A possibly damaging Het
Pira2 T A 7: 3,842,605 E260V probably damaging Het
Prickle3 T C X: 7,665,287 C277R probably damaging Het
Psen1 A G 12: 83,714,864 T147A probably damaging Het
Pxk C T 14: 8,151,014 probably benign Het
Scn11a G A 9: 119,819,847 P50L probably benign Het
Scn4a C A 11: 106,345,592 V281L probably benign Het
Shcbp1 A G 8: 4,739,166 I551T probably benign Het
Snx13 T A 12: 35,100,540 I281N probably benign Het
Tdo2 T C 3: 81,967,029 K209E probably benign Het
Trip6 C T 5: 137,312,884 R190Q probably benign Het
Ttc30a1 C T 2: 75,980,507 A411T probably benign Het
Ubqln1 T A 13: 58,180,858 E426D probably damaging Het
Zfp607b C A 7: 27,693,595 N49K possibly damaging Het
Other mutations in Adgrf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03080:Adgrf3 APN 5 30196829 missense probably benign 0.02
R0010:Adgrf3 UTSW 5 30205609 splice site probably benign
R0042:Adgrf3 UTSW 5 30197428 missense probably damaging 1.00
R0140:Adgrf3 UTSW 5 30196381 missense probably benign 0.19
R0617:Adgrf3 UTSW 5 30195080 missense probably benign 0.25
R0748:Adgrf3 UTSW 5 30196876 missense probably damaging 1.00
R1291:Adgrf3 UTSW 5 30199534 missense probably damaging 0.99
R1330:Adgrf3 UTSW 5 30195095 missense probably benign 0.24
R1468:Adgrf3 UTSW 5 30202229 splice site probably benign
R1695:Adgrf3 UTSW 5 30203555 missense probably benign 0.05
R1716:Adgrf3 UTSW 5 30197551 missense probably benign 0.03
R1844:Adgrf3 UTSW 5 30199213 missense probably damaging 0.96
R1935:Adgrf3 UTSW 5 30202306 missense probably benign 0.00
R1936:Adgrf3 UTSW 5 30202306 missense probably benign 0.00
R2059:Adgrf3 UTSW 5 30199491 missense possibly damaging 0.91
R2656:Adgrf3 UTSW 5 30196438 missense possibly damaging 0.96
R2913:Adgrf3 UTSW 5 30196994 missense probably damaging 1.00
R2914:Adgrf3 UTSW 5 30196994 missense probably damaging 1.00
R2987:Adgrf3 UTSW 5 30197360 missense probably damaging 1.00
R3797:Adgrf3 UTSW 5 30196823 missense possibly damaging 0.49
R3798:Adgrf3 UTSW 5 30196823 missense possibly damaging 0.49
R3799:Adgrf3 UTSW 5 30196823 missense possibly damaging 0.49
R3934:Adgrf3 UTSW 5 30200434 unclassified probably benign
R4043:Adgrf3 UTSW 5 30204362 missense probably benign 0.00
R4080:Adgrf3 UTSW 5 30197369 nonsense probably null
R4575:Adgrf3 UTSW 5 30202257 missense probably benign 0.00
R4754:Adgrf3 UTSW 5 30197617 critical splice acceptor site probably null
R4819:Adgrf3 UTSW 5 30198444 missense possibly damaging 0.66
R4893:Adgrf3 UTSW 5 30200478 missense probably benign 0.00
R4991:Adgrf3 UTSW 5 30199148 missense probably benign 0.26
R5686:Adgrf3 UTSW 5 30197306 missense probably damaging 1.00
R5965:Adgrf3 UTSW 5 30205639 missense probably benign 0.00
R5997:Adgrf3 UTSW 5 30198362 critical splice donor site probably null
R6103:Adgrf3 UTSW 5 30196267 missense probably damaging 1.00
R6244:Adgrf3 UTSW 5 30197533 missense probably benign 0.17
R6409:Adgrf3 UTSW 5 30197314 missense probably damaging 0.96
R6575:Adgrf3 UTSW 5 30196524 missense possibly damaging 0.72
R6745:Adgrf3 UTSW 5 30203603 missense probably benign 0.31
R6790:Adgrf3 UTSW 5 30196387 missense probably benign 0.00
R6813:Adgrf3 UTSW 5 30197521 missense probably damaging 0.96
R7202:Adgrf3 UTSW 5 30204380 nonsense probably null
R7250:Adgrf3 UTSW 5 30195682 missense probably damaging 1.00
R7353:Adgrf3 UTSW 5 30198497 missense probably damaging 0.98
R7634:Adgrf3 UTSW 5 30202247 missense probably benign 0.01
R7658:Adgrf3 UTSW 5 30197206 missense probably benign 0.41
R8037:Adgrf3 UTSW 5 30199512 missense probably damaging 1.00
Z1088:Adgrf3 UTSW 5 30199120 missense possibly damaging 0.90
Posted On2016-08-02