Incidental Mutation 'IGL03172:Olfr832'
ID411873
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr832
Ensembl Gene ENSMUSG00000095957
Gene Nameolfactory receptor 832
SynonymsMOR153-1, GA_x6K02T2PVTD-12687800-12688738
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.316) question?
Stock #IGL03172
Quality Score
Status
Chromosome9
Chromosomal Location18937122-18948940 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 18945461 bp
ZygosityHeterozygous
Amino Acid Change Serine to Asparagine at position 271 (S271N)
Ref Sequence ENSEMBL: ENSMUSP00000151834 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060601] [ENSMUST00000218385]
Predicted Effect probably benign
Transcript: ENSMUST00000060601
AA Change: S271N

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000056724
Gene: ENSMUSG00000095957
AA Change: S271N

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-51 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.1e-6 PFAM
Pfam:7tm_1 41 290 1.4e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218385
AA Change: S271N

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,948,176 H528R probably damaging Het
A530053G22Rik A T 6: 60,402,062 noncoding transcript Het
Aagab A G 9: 63,635,394 probably benign Het
Aknad1 A T 3: 108,781,203 I616F possibly damaging Het
Ap2a1 A C 7: 44,904,055 D629E probably benign Het
Apc2 C A 10: 80,313,386 Q1425K probably damaging Het
Asf1b A C 8: 83,967,913 H102P probably benign Het
Celf6 C T 9: 59,582,282 A90V probably damaging Het
Chrna2 A T 14: 66,142,239 Q9L probably benign Het
Csnk1g3 A G 18: 53,953,284 I420M possibly damaging Het
Eml3 T C 19: 8,939,179 probably benign Het
Epn3 T C 11: 94,491,630 N508S possibly damaging Het
Fam120a T C 13: 48,910,336 Y608C probably damaging Het
Fbn1 A C 2: 125,320,968 C2133G possibly damaging Het
Fhl5 A G 4: 25,211,309 F128L probably damaging Het
Fn1 T C 1: 71,641,262 N428S probably damaging Het
Fxr2 T C 11: 69,649,839 probably null Het
Gabrp T C 11: 33,554,388 Y309C probably damaging Het
Golga2 A G 2: 32,292,156 I50V probably benign Het
Ifi203 C T 1: 173,936,592 G105R possibly damaging Het
Itgav A T 2: 83,765,846 Q201L possibly damaging Het
Jade2 T C 11: 51,825,371 T336A probably damaging Het
Kdm4b A G 17: 56,401,649 D996G probably damaging Het
Me2 A G 18: 73,770,726 I557T probably benign Het
Memo1 A C 17: 74,245,001 L100R probably damaging Het
Mrps2 A G 2: 28,469,806 N225S probably damaging Het
Ndufa2 A G 18: 36,744,225 probably null Het
Olfr130 G T 17: 38,067,384 C71F probably damaging Het
Pak7 G T 2: 136,098,390 Y501* probably null Het
Pot1b A T 17: 55,695,206 F123I possibly damaging Het
Rev3l T C 10: 39,824,790 V1761A probably benign Het
Samd3 T A 10: 26,230,166 V14E probably damaging Het
Slc4a8 G A 15: 100,799,717 A605T probably benign Het
Smgc A T 15: 91,860,444 D333V probably damaging Het
Spata4 A G 8: 54,602,405 I147V probably benign Het
Ttc23l G A 15: 10,537,566 S206L probably benign Het
Vmn2r73 G A 7: 85,858,287 H606Y probably benign Het
Vsig8 A G 1: 172,560,349 N2S probably damaging Het
Wdr17 A C 8: 54,661,480 I667R probably damaging Het
Yif1b A G 7: 29,238,448 probably null Het
Zbtb5 A T 4: 44,994,003 H460Q possibly damaging Het
Zdhhc21 G A 4: 82,806,327 probably benign Het
Zfp944 A T 17: 22,340,037 H76Q probably damaging Het
Zkscan1 A G 5: 138,094,002 Q146R probably benign Het
Other mutations in Olfr832
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03018:Olfr832 APN 9 18944881 missense probably damaging 0.98
R0537:Olfr832 UTSW 9 18945148 missense probably damaging 1.00
R1923:Olfr832 UTSW 9 18945485 missense probably benign 0.21
R2226:Olfr832 UTSW 9 18944881 missense probably damaging 0.98
R2234:Olfr832 UTSW 9 18944816 missense probably damaging 1.00
R2402:Olfr832 UTSW 9 18945200 missense probably damaging 0.98
R4060:Olfr832 UTSW 9 18945050 missense probably benign 0.09
R4537:Olfr832 UTSW 9 18945230 missense possibly damaging 0.85
R4715:Olfr832 UTSW 9 18945446 missense probably benign 0.01
R5557:Olfr832 UTSW 9 18945170 missense possibly damaging 0.94
R6001:Olfr832 UTSW 9 18945044 missense probably damaging 1.00
R6172:Olfr832 UTSW 9 18944746 missense probably benign 0.00
R6415:Olfr832 UTSW 9 18945119 missense probably damaging 1.00
R6594:Olfr832 UTSW 9 18944831 missense probably damaging 0.98
R6874:Olfr832 UTSW 9 18945481 missense possibly damaging 0.95
R7801:Olfr832 UTSW 9 18945259 missense probably damaging 0.97
R7818:Olfr832 UTSW 9 18945009 nonsense probably null
R7880:Olfr832 UTSW 9 18944728 missense probably benign 0.06
R7890:Olfr832 UTSW 9 18945503 missense probably benign 0.10
R8352:Olfr832 UTSW 9 18945163 missense possibly damaging 0.51
R8452:Olfr832 UTSW 9 18945163 missense possibly damaging 0.51
Z1088:Olfr832 UTSW 9 18945421 missense possibly damaging 0.69
Posted On2016-08-02