Incidental Mutation 'IGL03172:Or2g7'
ID 411882
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2g7
Ensembl Gene ENSMUSG00000094878
Gene Name olfactory receptor family 2 subfamily G member 7
Synonyms GA_x6K02T2PSCP-2515350-2516303, MOR256-19, Olfr130
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # IGL03172
Quality Score
Status
Chromosome 17
Chromosomal Location 38378064-38379017 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 38378275 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Phenylalanine at position 71 (C71F)
Ref Sequence ENSEMBL: ENSMUSP00000149601 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087129] [ENSMUST00000215726] [ENSMUST00000217390]
AlphaFold Q8VFC1
Predicted Effect probably damaging
Transcript: ENSMUST00000087129
AA Change: C71F

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000084369
Gene: ENSMUSG00000094878
AA Change: C71F

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 1.8e-44 PFAM
Pfam:7TM_GPCR_Srsx 34 223 1.9e-5 PFAM
Pfam:7tm_1 40 289 1.9e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215726
AA Change: C71F

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000217390
AA Change: C71F

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,839,003 (GRCm39) H528R probably damaging Het
A530053G22Rik A T 6: 60,379,047 (GRCm39) noncoding transcript Het
Aagab A G 9: 63,542,676 (GRCm39) probably benign Het
Aknad1 A T 3: 108,688,519 (GRCm39) I616F possibly damaging Het
Ap2a1 A C 7: 44,553,479 (GRCm39) D629E probably benign Het
Apc2 C A 10: 80,149,220 (GRCm39) Q1425K probably damaging Het
Asf1b A C 8: 84,694,542 (GRCm39) H102P probably benign Het
Celf6 C T 9: 59,489,565 (GRCm39) A90V probably damaging Het
Chrna2 A T 14: 66,379,688 (GRCm39) Q9L probably benign Het
Csnk1g3 A G 18: 54,086,356 (GRCm39) I420M possibly damaging Het
Eml3 T C 19: 8,916,543 (GRCm39) probably benign Het
Epn3 T C 11: 94,382,456 (GRCm39) N508S possibly damaging Het
Fam120a T C 13: 49,063,812 (GRCm39) Y608C probably damaging Het
Fbn1 A C 2: 125,162,888 (GRCm39) C2133G possibly damaging Het
Fhl5 A G 4: 25,211,309 (GRCm39) F128L probably damaging Het
Fn1 T C 1: 71,680,421 (GRCm39) N428S probably damaging Het
Fxr2 T C 11: 69,540,665 (GRCm39) probably null Het
Gabrp T C 11: 33,504,388 (GRCm39) Y309C probably damaging Het
Golga2 A G 2: 32,182,168 (GRCm39) I50V probably benign Het
Ifi203 C T 1: 173,764,158 (GRCm39) G105R possibly damaging Het
Itgav A T 2: 83,596,190 (GRCm39) Q201L possibly damaging Het
Jade2 T C 11: 51,716,198 (GRCm39) T336A probably damaging Het
Kdm4b A G 17: 56,708,649 (GRCm39) D996G probably damaging Het
Me2 A G 18: 73,903,797 (GRCm39) I557T probably benign Het
Memo1 A C 17: 74,551,996 (GRCm39) L100R probably damaging Het
Mrps2 A G 2: 28,359,818 (GRCm39) N225S probably damaging Het
Ndufa2 A G 18: 36,877,278 (GRCm39) probably null Het
Or7g19 G A 9: 18,856,757 (GRCm39) S271N probably benign Het
Pak5 G T 2: 135,940,310 (GRCm39) Y501* probably null Het
Pot1b A T 17: 56,002,206 (GRCm39) F123I possibly damaging Het
Rev3l T C 10: 39,700,786 (GRCm39) V1761A probably benign Het
Samd3 T A 10: 26,106,064 (GRCm39) V14E probably damaging Het
Slc4a8 G A 15: 100,697,598 (GRCm39) A605T probably benign Het
Smgc A T 15: 91,744,642 (GRCm39) D333V probably damaging Het
Spata4 A G 8: 55,055,440 (GRCm39) I147V probably benign Het
Ttc23l G A 15: 10,537,652 (GRCm39) S206L probably benign Het
Vmn2r73 G A 7: 85,507,495 (GRCm39) H606Y probably benign Het
Vsig8 A G 1: 172,387,916 (GRCm39) N2S probably damaging Het
Wdr17 A C 8: 55,114,515 (GRCm39) I667R probably damaging Het
Yif1b A G 7: 28,937,873 (GRCm39) probably null Het
Zbtb5 A T 4: 44,994,003 (GRCm39) H460Q possibly damaging Het
Zdhhc21 G A 4: 82,724,564 (GRCm39) probably benign Het
Zfp944 A T 17: 22,559,018 (GRCm39) H76Q probably damaging Het
Zkscan1 A G 5: 138,092,264 (GRCm39) Q146R probably benign Het
Other mutations in Or2g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01527:Or2g7 APN 17 38,378,986 (GRCm39) missense probably benign
IGL02158:Or2g7 APN 17 38,378,158 (GRCm39) missense probably damaging 0.97
R0389:Or2g7 UTSW 17 38,378,562 (GRCm39) missense possibly damaging 0.58
R0448:Or2g7 UTSW 17 38,378,563 (GRCm39) missense probably benign 0.00
R0616:Or2g7 UTSW 17 38,378,131 (GRCm39) missense probably damaging 1.00
R0961:Or2g7 UTSW 17 38,378,814 (GRCm39) missense probably damaging 1.00
R1789:Or2g7 UTSW 17 38,378,839 (GRCm39) missense probably damaging 1.00
R2108:Or2g7 UTSW 17 38,378,746 (GRCm39) missense possibly damaging 0.82
R4600:Or2g7 UTSW 17 38,378,853 (GRCm39) missense probably damaging 0.99
R4977:Or2g7 UTSW 17 38,378,638 (GRCm39) missense possibly damaging 0.67
R5120:Or2g7 UTSW 17 38,378,157 (GRCm39) missense probably damaging 0.97
R5930:Or2g7 UTSW 17 38,378,641 (GRCm39) missense probably benign 0.11
R6273:Or2g7 UTSW 17 38,378,686 (GRCm39) missense probably damaging 1.00
R6636:Or2g7 UTSW 17 38,378,115 (GRCm39) missense probably damaging 0.98
R6637:Or2g7 UTSW 17 38,378,115 (GRCm39) missense probably damaging 0.98
R7030:Or2g7 UTSW 17 38,378,948 (GRCm39) missense probably benign 0.13
R7045:Or2g7 UTSW 17 38,378,862 (GRCm39) missense probably benign 0.01
R7175:Or2g7 UTSW 17 38,378,370 (GRCm39) missense probably damaging 0.96
R7359:Or2g7 UTSW 17 38,378,506 (GRCm39) nonsense probably null
R7762:Or2g7 UTSW 17 38,378,566 (GRCm39) missense probably damaging 1.00
R7980:Or2g7 UTSW 17 38,378,412 (GRCm39) missense possibly damaging 0.64
R8050:Or2g7 UTSW 17 38,378,370 (GRCm39) missense probably damaging 1.00
R9035:Or2g7 UTSW 17 38,378,179 (GRCm39) missense probably benign 0.00
X0019:Or2g7 UTSW 17 38,378,613 (GRCm39) missense probably benign 0.01
Posted On 2016-08-02