Incidental Mutation 'IGL03173:Zfp663'
| ID |
411919 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp663
|
| Ensembl Gene |
ENSMUSG00000056824 |
| Gene Name |
zinc finger protein 663 |
| Synonyms |
LOC381405, Gm1008 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.068)
|
| Stock # |
IGL03173
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
2 |
| Chromosomal Location |
165193217-165210649 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 165194419 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Lysine
at position 600
(T600K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099374
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073062]
[ENSMUST00000103085]
[ENSMUST00000141140]
|
| AlphaFold |
Q6NXM6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000073062
AA Change: T600K
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000072813
Gene: ENSMUSG00000056824
AA Change: T600K
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
1.97e-31 |
SMART |
|
ZnF_C2H2
|
205 |
227 |
3.47e1 |
SMART |
|
ZnF_C2H2
|
472 |
494 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
528 |
550 |
2.43e-4 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
612 |
635 |
8.6e-5 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000103085
AA Change: T600K
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000099374
Gene: ENSMUSG00000056824
AA Change: T600K
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
1.97e-31 |
SMART |
|
ZnF_C2H2
|
205 |
227 |
3.47e1 |
SMART |
|
ZnF_C2H2
|
472 |
494 |
2.4e-3 |
SMART |
|
ZnF_C2H2
|
500 |
522 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
528 |
550 |
2.43e-4 |
SMART |
|
ZnF_C2H2
|
556 |
578 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
584 |
606 |
3.95e-4 |
SMART |
|
ZnF_C2H2
|
612 |
635 |
8.6e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000136482
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000141140
|
| SMART Domains |
Protein: ENSMUSP00000115254
Gene: ENSMUSG00000056824
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
1.97e-31 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atg2b |
T |
C |
12: 105,624,553 (GRCm39) |
K649E |
possibly damaging |
Het |
| Cnnm4 |
A |
G |
1: 36,512,173 (GRCm39) |
|
probably benign |
Het |
| Cntrob |
C |
T |
11: 69,200,853 (GRCm39) |
A503T |
possibly damaging |
Het |
| D3Ertd751e |
T |
A |
3: 41,710,497 (GRCm39) |
Y170N |
probably damaging |
Het |
| Ddx23 |
T |
C |
15: 98,548,885 (GRCm39) |
I306V |
probably benign |
Het |
| Ep400 |
A |
G |
5: 110,856,737 (GRCm39) |
|
probably benign |
Het |
| Gmps |
T |
C |
3: 63,897,750 (GRCm39) |
V234A |
probably damaging |
Het |
| Hivep2 |
G |
T |
10: 14,003,726 (GRCm39) |
G108V |
possibly damaging |
Het |
| Irgc |
T |
C |
7: 24,132,727 (GRCm39) |
E30G |
probably damaging |
Het |
| Krt75 |
T |
C |
15: 101,481,162 (GRCm39) |
Y204C |
probably damaging |
Het |
| Ms4a14 |
G |
A |
19: 11,281,560 (GRCm39) |
L333F |
possibly damaging |
Het |
| Or51l4 |
A |
G |
7: 103,404,183 (GRCm39) |
V203A |
probably benign |
Het |
| Or5an6 |
T |
A |
19: 12,372,410 (GRCm39) |
M261K |
possibly damaging |
Het |
| Or8k27 |
A |
T |
2: 86,275,788 (GRCm39) |
C179* |
probably null |
Het |
| Pitpnm3 |
G |
A |
11: 71,983,389 (GRCm39) |
T80I |
probably benign |
Het |
| Pou2f2 |
T |
C |
7: 24,799,371 (GRCm39) |
|
probably benign |
Het |
| Slc34a1 |
T |
C |
13: 55,561,089 (GRCm39) |
L518P |
probably damaging |
Het |
| Sorbs1 |
T |
A |
19: 40,351,706 (GRCm39) |
T235S |
probably damaging |
Het |
| Ssxa1 |
C |
T |
X: 20,985,224 (GRCm39) |
R41C |
probably benign |
Het |
| Syt2 |
A |
G |
1: 134,671,317 (GRCm39) |
N142D |
possibly damaging |
Het |
| Taf3 |
A |
G |
2: 9,957,738 (GRCm39) |
V143A |
probably damaging |
Het |
| Trav13-5 |
T |
C |
14: 54,033,534 (GRCm39) |
|
probably benign |
Het |
| Tti1 |
A |
G |
2: 157,848,932 (GRCm39) |
|
probably benign |
Het |
| Vmn2r13 |
T |
C |
5: 109,319,645 (GRCm39) |
E445G |
possibly damaging |
Het |
| Zfp750 |
G |
A |
11: 121,404,651 (GRCm39) |
Q75* |
probably null |
Het |
|
| Other mutations in Zfp663 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00720:Zfp663
|
APN |
2 |
165,194,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01382:Zfp663
|
APN |
2 |
165,200,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02007:Zfp663
|
APN |
2 |
165,200,993 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02164:Zfp663
|
APN |
2 |
165,200,968 (GRCm39) |
nonsense |
probably null |
|
|
IGL02506:Zfp663
|
APN |
2 |
165,195,871 (GRCm39) |
missense |
probably benign |
0.35 |
|
R0735:Zfp663
|
UTSW |
2 |
165,200,995 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1395:Zfp663
|
UTSW |
2 |
165,194,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1402:Zfp663
|
UTSW |
2 |
165,195,890 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1402:Zfp663
|
UTSW |
2 |
165,195,890 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1503:Zfp663
|
UTSW |
2 |
165,194,573 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1587:Zfp663
|
UTSW |
2 |
165,195,437 (GRCm39) |
missense |
probably benign |
|
|
R1854:Zfp663
|
UTSW |
2 |
165,195,211 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1867:Zfp663
|
UTSW |
2 |
165,194,651 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R3031:Zfp663
|
UTSW |
2 |
165,195,616 (GRCm39) |
nonsense |
probably null |
|
|
R4643:Zfp663
|
UTSW |
2 |
165,194,925 (GRCm39) |
missense |
probably benign |
0.24 |
|
R4691:Zfp663
|
UTSW |
2 |
165,201,050 (GRCm39) |
intron |
probably benign |
|
|
R4977:Zfp663
|
UTSW |
2 |
165,195,731 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5135:Zfp663
|
UTSW |
2 |
165,195,590 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5151:Zfp663
|
UTSW |
2 |
165,195,113 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5639:Zfp663
|
UTSW |
2 |
165,194,929 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5763:Zfp663
|
UTSW |
2 |
165,200,355 (GRCm39) |
nonsense |
probably null |
|
|
R6776:Zfp663
|
UTSW |
2 |
165,200,935 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6929:Zfp663
|
UTSW |
2 |
165,195,178 (GRCm39) |
missense |
probably benign |
|
|
R6998:Zfp663
|
UTSW |
2 |
165,195,922 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R7035:Zfp663
|
UTSW |
2 |
165,195,023 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7169:Zfp663
|
UTSW |
2 |
165,194,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7529:Zfp663
|
UTSW |
2 |
165,194,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7790:Zfp663
|
UTSW |
2 |
165,194,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8087:Zfp663
|
UTSW |
2 |
165,195,679 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8715:Zfp663
|
UTSW |
2 |
165,194,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8934:Zfp663
|
UTSW |
2 |
165,194,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8966:Zfp663
|
UTSW |
2 |
165,194,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9257:Zfp663
|
UTSW |
2 |
165,195,974 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9278:Zfp663
|
UTSW |
2 |
165,202,010 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9524:Zfp663
|
UTSW |
2 |
165,195,607 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF004:Zfp663
|
UTSW |
2 |
165,200,363 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Zfp663
|
UTSW |
2 |
165,195,033 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2016-08-02 |
Incidental Mutation