Incidental Mutation 'IGL03177:Zfp809'
ID412022
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp809
Ensembl Gene ENSMUSG00000057982
Gene Namezinc finger protein 809
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.121) question?
Stock #IGL03177
Quality Score
Status
Chromosome9
Chromosomal Location22225714-22243354 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 22235051 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 12 (D12G)
Ref Sequence ENSEMBL: ENSMUSP00000151180 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072465] [ENSMUST00000213371] [ENSMUST00000215618] [ENSMUST00000215902]
Predicted Effect probably damaging
Transcript: ENSMUST00000072465
AA Change: D12G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000072286
Gene: ENSMUSG00000057982
AA Change: D12G

DomainStartEndE-ValueType
KRAB 4 64 7.56e-33 SMART
ZnF_C2H2 155 178 2.4e-3 SMART
ZnF_C2H2 184 206 4.79e-3 SMART
ZnF_C2H2 213 235 5.21e-4 SMART
ZnF_C2H2 241 263 2.57e-3 SMART
ZnF_C2H2 269 291 1.28e-3 SMART
ZnF_C2H2 297 319 1.1e-2 SMART
ZnF_C2H2 325 347 6.32e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213350
Predicted Effect probably benign
Transcript: ENSMUST00000213371
AA Change: D12G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213592
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215583
Predicted Effect probably damaging
Transcript: ENSMUST00000215618
AA Change: D12G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215902
AA Change: D12G

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased expression of VL30-pro endogenous retroviruses (ERV) elements. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg2 T C X: 160,438,263 I23T possibly damaging Het
Ank2 C A 3: 126,955,870 E503D probably damaging Het
Anxa7 T C 14: 20,456,586 I451V probably benign Het
Capn10 T C 1: 92,934,982 F37L probably benign Het
Cyp4f13 A G 17: 32,946,914 I30T possibly damaging Het
Ddx27 A G 2: 167,027,920 N392D possibly damaging Het
Dhx30 T C 9: 110,088,010 H479R possibly damaging Het
Dnah5 A G 15: 28,295,399 Y1426C probably damaging Het
Dnajc2 A G 5: 21,775,081 probably benign Het
Fbxw8 C A 5: 118,128,980 probably benign Het
Grik5 G A 7: 25,015,454 T705I probably damaging Het
H2-M3 G T 17: 37,270,316 V19F possibly damaging Het
Hapln2 C A 3: 88,022,771 C266F probably damaging Het
Hist1h2ab T A 13: 23,751,526 probably benign Het
Hspbp1 A T 7: 4,664,701 probably null Het
Jak3 T A 8: 71,682,370 V549D probably damaging Het
Mark1 A G 1: 184,944,907 S49P probably damaging Het
Mdfic T C 6: 15,770,451 V152A probably damaging Het
Mgat4a C A 1: 37,444,887 V501L probably damaging Het
Mlxip C A 5: 123,445,981 P536T possibly damaging Het
Mrpl2 A T 17: 46,649,037 T213S probably damaging Het
Nos1ap C A 1: 170,390,730 probably null Het
Olfr1247 C T 2: 89,609,482 V207I probably benign Het
Olfr786 T C 10: 129,436,815 M1T probably null Het
Olfr914 T A 9: 38,606,571 Y35* probably null Het
P2rx2 T C 5: 110,341,613 I251V probably damaging Het
Parva T A 7: 112,572,933 probably benign Het
Phf10 G A 17: 14,946,231 T459I probably damaging Het
Prg4 T A 1: 150,455,603 probably benign Het
Pum3 A T 19: 27,390,212 I639N probably benign Het
Rlf T A 4: 121,148,079 K1235* probably null Het
Ryr3 T A 2: 113,028,671 I46F probably benign Het
Sall3 A G 18: 80,972,968 S582P probably benign Het
Scn3b A C 9: 40,270,042 Y17S probably benign Het
Senp8 A G 9: 59,737,328 C169R probably damaging Het
Sgsm1 C T 5: 113,250,993 A1025T probably damaging Het
Six1 T C 12: 73,043,740 E217G possibly damaging Het
Slc38a8 T C 8: 119,485,512 D364G probably damaging Het
Stk10 A T 11: 32,614,592 E801V probably damaging Het
Ston2 A T 12: 91,647,657 I659N probably damaging Het
Stxbp4 T C 11: 90,571,753 Q331R probably benign Het
Synpo2 A T 3: 123,121,215 V54E probably damaging Het
Tax1bp1 A G 6: 52,736,947 D237G possibly damaging Het
Tmigd1 T C 11: 76,906,948 Y39H probably benign Het
Vmn1r15 A G 6: 57,258,473 T109A probably benign Het
Vmn1r209 T C 13: 22,805,854 Y222C possibly damaging Het
Other mutations in Zfp809
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02967:Zfp809 APN 9 22235102 missense probably damaging 1.00
IGL03117:Zfp809 APN 9 22238654 missense probably damaging 0.99
IGL03250:Zfp809 APN 9 22238635 missense possibly damaging 0.91
IGL03265:Zfp809 APN 9 22243043 missense probably benign 0.20
R1080:Zfp809 UTSW 9 22235109 missense probably damaging 0.98
R1544:Zfp809 UTSW 9 22235099 missense probably damaging 1.00
R1875:Zfp809 UTSW 9 22238731 nonsense probably null
R2137:Zfp809 UTSW 9 22235138 missense probably benign 0.07
R2314:Zfp809 UTSW 9 22238680 missense possibly damaging 0.95
R2356:Zfp809 UTSW 9 22243040 missense probably benign 0.00
R5019:Zfp809 UTSW 9 22237702 missense probably benign 0.44
R5735:Zfp809 UTSW 9 22238931 nonsense probably null
R6483:Zfp809 UTSW 9 22236244 missense probably benign
R7106:Zfp809 UTSW 9 22236224 missense probably benign 0.04
Posted On2016-08-02