Incidental Mutation 'IGL03177:Zfp809'
ID 412022
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp809
Ensembl Gene ENSMUSG00000057982
Gene Name zinc finger protein 809
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.206) question?
Stock # IGL03177
Quality Score
Status
Chromosome 9
Chromosomal Location 22137010-22154650 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 22146347 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 12 (D12G)
Ref Sequence ENSEMBL: ENSMUSP00000151180 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072465] [ENSMUST00000213371] [ENSMUST00000215618] [ENSMUST00000215902]
AlphaFold G3X9G7
Predicted Effect probably damaging
Transcript: ENSMUST00000072465
AA Change: D12G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000072286
Gene: ENSMUSG00000057982
AA Change: D12G

DomainStartEndE-ValueType
KRAB 4 64 7.56e-33 SMART
ZnF_C2H2 155 178 2.4e-3 SMART
ZnF_C2H2 184 206 4.79e-3 SMART
ZnF_C2H2 213 235 5.21e-4 SMART
ZnF_C2H2 241 263 2.57e-3 SMART
ZnF_C2H2 269 291 1.28e-3 SMART
ZnF_C2H2 297 319 1.1e-2 SMART
ZnF_C2H2 325 347 6.32e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213350
Predicted Effect probably benign
Transcript: ENSMUST00000213371
AA Change: D12G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213592
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215583
Predicted Effect probably damaging
Transcript: ENSMUST00000215618
AA Change: D12G

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect possibly damaging
Transcript: ENSMUST00000215902
AA Change: D12G

PolyPhen 2 Score 0.926 (Sensitivity: 0.81; Specificity: 0.94)
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased expression of VL30-pro endogenous retroviruses (ERV) elements. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrg2 T C X: 159,221,259 (GRCm39) I23T possibly damaging Het
Ank2 C A 3: 126,749,519 (GRCm39) E503D probably damaging Het
Anxa7 T C 14: 20,506,654 (GRCm39) I451V probably benign Het
Capn10 T C 1: 92,862,704 (GRCm39) F37L probably benign Het
Cyp4f13 A G 17: 33,165,888 (GRCm39) I30T possibly damaging Het
Ddx27 A G 2: 166,869,840 (GRCm39) N392D possibly damaging Het
Dhx30 T C 9: 109,917,078 (GRCm39) H479R possibly damaging Het
Dnah5 A G 15: 28,295,545 (GRCm39) Y1426C probably damaging Het
Dnajc2 A G 5: 21,980,079 (GRCm39) probably benign Het
Fbxw8 C A 5: 118,267,045 (GRCm39) probably benign Het
Grik5 G A 7: 24,714,879 (GRCm39) T705I probably damaging Het
H2ac4 T A 13: 23,935,509 (GRCm39) probably benign Het
H2-M3 G T 17: 37,581,207 (GRCm39) V19F possibly damaging Het
Hapln2 C A 3: 87,930,078 (GRCm39) C266F probably damaging Het
Hspbp1 A T 7: 4,667,700 (GRCm39) probably null Het
Jak3 T A 8: 72,135,014 (GRCm39) V549D probably damaging Het
Mark1 A G 1: 184,677,104 (GRCm39) S49P probably damaging Het
Mdfic T C 6: 15,770,450 (GRCm39) V152A probably damaging Het
Mgat4a C A 1: 37,483,968 (GRCm39) V501L probably damaging Het
Mlxip C A 5: 123,584,044 (GRCm39) P536T possibly damaging Het
Mrpl2 A T 17: 46,959,963 (GRCm39) T213S probably damaging Het
Nos1ap C A 1: 170,218,299 (GRCm39) probably null Het
Or4a74 C T 2: 89,439,826 (GRCm39) V207I probably benign Het
Or6c1b T C 10: 129,272,684 (GRCm39) M1T probably null Het
Or8b50 T A 9: 38,517,867 (GRCm39) Y35* probably null Het
P2rx2 T C 5: 110,489,479 (GRCm39) I251V probably damaging Het
Parva T A 7: 112,172,140 (GRCm39) probably benign Het
Phf10 G A 17: 15,166,493 (GRCm39) T459I probably damaging Het
Prg4 T A 1: 150,331,354 (GRCm39) probably benign Het
Pum3 A T 19: 27,367,612 (GRCm39) I639N probably benign Het
Rlf T A 4: 121,005,276 (GRCm39) K1235* probably null Het
Ryr3 T A 2: 112,859,016 (GRCm39) I46F probably benign Het
Sall3 A G 18: 81,016,183 (GRCm39) S582P probably benign Het
Scn3b A C 9: 40,181,338 (GRCm39) Y17S probably benign Het
Senp8 A G 9: 59,644,611 (GRCm39) C169R probably damaging Het
Sgsm1 C T 5: 113,398,859 (GRCm39) A1025T probably damaging Het
Six1 T C 12: 73,090,514 (GRCm39) E217G possibly damaging Het
Slc38a8 T C 8: 120,212,251 (GRCm39) D364G probably damaging Het
Stk10 A T 11: 32,564,592 (GRCm39) E801V probably damaging Het
Ston2 A T 12: 91,614,431 (GRCm39) I659N probably damaging Het
Stxbp4 T C 11: 90,462,579 (GRCm39) Q331R probably benign Het
Synpo2 A T 3: 122,914,864 (GRCm39) V54E probably damaging Het
Tax1bp1 A G 6: 52,713,932 (GRCm39) D237G possibly damaging Het
Tmigd1 T C 11: 76,797,774 (GRCm39) Y39H probably benign Het
Vmn1r15 A G 6: 57,235,458 (GRCm39) T109A probably benign Het
Vmn1r209 T C 13: 22,990,024 (GRCm39) Y222C possibly damaging Het
Other mutations in Zfp809
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02967:Zfp809 APN 9 22,146,398 (GRCm39) missense probably damaging 1.00
IGL03117:Zfp809 APN 9 22,149,950 (GRCm39) missense probably damaging 0.99
IGL03250:Zfp809 APN 9 22,149,931 (GRCm39) missense possibly damaging 0.91
IGL03265:Zfp809 APN 9 22,154,339 (GRCm39) missense probably benign 0.20
R1080:Zfp809 UTSW 9 22,146,405 (GRCm39) missense probably damaging 0.98
R1544:Zfp809 UTSW 9 22,146,395 (GRCm39) missense probably damaging 1.00
R1875:Zfp809 UTSW 9 22,150,027 (GRCm39) nonsense probably null
R2137:Zfp809 UTSW 9 22,146,434 (GRCm39) missense probably benign 0.07
R2314:Zfp809 UTSW 9 22,149,976 (GRCm39) missense possibly damaging 0.95
R2356:Zfp809 UTSW 9 22,154,336 (GRCm39) missense probably benign 0.00
R5019:Zfp809 UTSW 9 22,148,998 (GRCm39) missense probably benign 0.44
R5735:Zfp809 UTSW 9 22,150,227 (GRCm39) nonsense probably null
R6483:Zfp809 UTSW 9 22,147,540 (GRCm39) missense probably benign
R7106:Zfp809 UTSW 9 22,147,520 (GRCm39) missense probably benign 0.04
R8969:Zfp809 UTSW 9 22,137,130 (GRCm39) critical splice donor site probably null
R9364:Zfp809 UTSW 9 22,150,394 (GRCm39) missense probably damaging 0.99
R9600:Zfp809 UTSW 9 22,150,384 (GRCm39) missense possibly damaging 0.69
R9666:Zfp809 UTSW 9 22,149,863 (GRCm39) missense probably benign 0.07
R9700:Zfp809 UTSW 9 22,154,470 (GRCm39) missense unknown
Posted On 2016-08-02