Incidental Mutation 'IGL03179:Zcchc24'
ID412115
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zcchc24
Ensembl Gene ENSMUSG00000055538
Gene Namezinc finger, CCHC domain containing 24
Synonyms2310047A01Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.259) question?
Stock #IGL03179
Quality Score
Status
Chromosome14
Chromosomal Location25711642-25769039 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 25719662 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 193 (I193V)
Ref Sequence ENSEMBL: ENSMUSP00000068677 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069180]
Predicted Effect possibly damaging
Transcript: ENSMUST00000069180
AA Change: I193V

PolyPhen 2 Score 0.800 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000068677
Gene: ENSMUSG00000055538
AA Change: I193V

DomainStartEndE-ValueType
low complexity region 39 56 N/A INTRINSIC
ZnF_C2HC 133 149 3.74e-2 SMART
zf-3CxxC 165 233 1.81e-14 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184642
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932429P05Rik G A X: 89,752,828 G89S possibly damaging Het
AI314180 C T 4: 58,832,777 G861D probably damaging Het
Akap11 T A 14: 78,507,740 H1736L probably benign Het
App A G 16: 85,082,847 C133R probably damaging Het
Atxn7l2 G T 3: 108,203,647 C524* probably null Het
Cckbr T C 7: 105,434,923 V288A probably benign Het
Ccr1l1 T C 9: 123,977,750 Y220C probably damaging Het
Cdc42se2 A T 11: 54,723,591 F47I possibly damaging Het
Cep290 T A 10: 100,568,088 I2317N possibly damaging Het
Chrnd T C 1: 87,195,780 S347P probably damaging Het
Clcn5 T A X: 7,163,326 probably null Het
D6Wsu163e A G 6: 126,950,111 D187G probably damaging Het
Dnajc13 T A 9: 104,167,435 I1852F probably benign Het
Fcnb A G 2: 28,076,634 S296P possibly damaging Het
Fut2 C T 7: 45,650,649 R233K probably benign Het
Gm21985 G A 2: 112,358,555 V1078I possibly damaging Het
Gpc3 A T X: 52,397,213 probably benign Het
Krt10 A G 11: 99,389,218 probably benign Het
Lrrk2 A G 15: 91,700,578 E370G probably damaging Het
Myo5c A T 9: 75,255,866 I326F possibly damaging Het
Neb A T 2: 52,176,641 L5906Q probably damaging Het
Nrd1 A T 4: 109,046,691 probably benign Het
Nrip2 A G 6: 128,404,975 N17S possibly damaging Het
Olfr568 T C 7: 102,878,072 probably benign Het
Olfr750 T C 14: 51,071,010 I128V probably benign Het
P2rx7 A G 5: 122,673,700 Y358C possibly damaging Het
Pex10 A C 4: 155,067,897 I61L probably benign Het
Phax T C 18: 56,580,292 F248L probably damaging Het
Phtf2 A T 5: 20,782,399 D366E probably damaging Het
Pnpo A G 11: 96,939,259 Y205H possibly damaging Het
Pparg T A 6: 115,439,872 W9R probably damaging Het
Prex1 C T 2: 166,585,194 S867N probably benign Het
Pyroxd2 T A 19: 42,747,562 N59I possibly damaging Het
Rnf135 T A 11: 80,194,011 S203R possibly damaging Het
Sall1 T A 8: 89,031,661 N605I probably benign Het
Scara3 C T 14: 65,931,154 R338H probably damaging Het
Slc25a14 T C X: 48,637,440 S152P probably benign Het
Strip1 A T 3: 107,620,255 F436I probably damaging Het
Tgfa T C 6: 86,271,421 L135P probably benign Het
Tgif1 T C 17: 70,844,947 Q170R possibly damaging Het
Tmc2 G A 2: 130,229,187 E279K probably damaging Het
Tnks G T 8: 34,848,670 N987K probably benign Het
Traf3ip3 T C 1: 193,194,368 E209G probably damaging Het
Vmn2r73 T A 7: 85,870,260 I497L probably benign Het
Wrn C A 8: 33,310,706 probably null Het
Other mutations in Zcchc24
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0927:Zcchc24 UTSW 14 25757161 missense possibly damaging 0.63
R6747:Zcchc24 UTSW 14 25757033 missense probably damaging 1.00
R7980:Zcchc24 UTSW 14 25719761 missense probably damaging 1.00
R8870:Zcchc24 UTSW 14 25757154 missense probably benign 0.00
Posted On2016-08-02