Mutagenetix > Incidental Mutation

Incidental Mutation 'R0457:Vmn1r29'

41215

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r29

Ensembl Gene

ENSMUSG00000091734

Gene Name

vomeronasal 1 receptor 29

Synonyms

V1rc2

MMRRC Submission

038657-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.060) question?

Stock #

R0457 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

58301549-58311685 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 58308087 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 264 (V264A)

Ref Sequence

ENSEMBL: ENSMUSP00000154278 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168416] [ENSMUST00000226971] [ENSMUST00000227761] [ENSMUST00000228038] [ENSMUST00000228909]

AlphaFold

Q9EQ41

Predicted Effect

probably benign
Transcript: ENSMUST00000168416
AA Change: V264A

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000129069
Gene: ENSMUSG00000091734
AA Change: V264A

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	1.7e-53	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226971
AA Change: V264A

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000227761
AA Change: V264A

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000228038
AA Change: V264A

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

probably benign
Transcript: ENSMUST00000228909
AA Change: V264A

PolyPhen 2 Score 0.350 (Sensitivity: 0.90; Specificity: 0.89)

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.4%
20x: 92.9%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy5	T	C	16: 35,274,545	S691P	probably benign	Het
Aspscr1	A	G	11: 120,677,618	E12G	probably benign	Het
Atp2a2	T	C	5: 122,469,714	Q244R	probably benign	Het
Birc6	A	G	17: 74,652,028	M3818V	probably benign	Het
Birc6	C	T	17: 74,662,625	A4230V	probably damaging	Het
Bub1b	T	C	2: 118,609,859	F148S	probably damaging	Het
C130079G13Rik	A	G	3: 59,936,633	I249M	possibly damaging	Het
C1ra	T	C	6: 124,522,753	S633P	probably benign	Het
Cacna2d1	A	G	5: 16,267,416	T274A	probably damaging	Het
Cmya5	A	G	13: 93,095,587	W998R	possibly damaging	Het
Crbn	T	C	6: 106,781,057	K404R	probably benign	Het
Cryga	T	C	1: 65,103,045	Y63C	probably damaging	Het
Csmd1	C	A	8: 16,501,393		probably null	Het
Defa-ps1	A	T	8: 21,695,742		noncoding transcript	Het
Dnajc10	T	A	2: 80,344,946	V559D	possibly damaging	Het
Dock1	A	T	7: 135,138,145	E1423D	possibly damaging	Het
Dpf3	A	T	12: 83,272,405	S44T	probably damaging	Het
Dyrk3	A	T	1: 131,136,357	V31D	possibly damaging	Het
F5	T	C	1: 164,194,200	S1415P	probably benign	Het
Fam186b	A	C	15: 99,271,285	I927S	probably benign	Het
Fcho1	C	T	8: 71,712,560	A418T	probably benign	Het
Fer1l6	G	A	15: 58,638,094		probably null	Het
Fndc7	G	T	3: 108,876,545	S249R	probably benign	Het
Ganab	A	G	19: 8,907,250	E139G	possibly damaging	Het
Gbp5	A	G	3: 142,507,757	D478G	probably damaging	Het
Gm17324	T	A	9: 78,448,298	M1K	probably null	Het
Gm996	G	T	2: 25,578,346	R518S	possibly damaging	Het
Gtpbp6	T	A	5: 110,106,742	R126S	probably damaging	Het
Hapln4	G	A	8: 70,088,472	W385*	probably null	Het
Hmcn2	T	A	2: 31,415,284		probably null	Het
Hsp90ab1	A	G	17: 45,568,988	V534A	probably damaging	Het
Kat6b	C	A	14: 21,670,530	T1650K	probably damaging	Het
Kpna1	T	A	16: 36,002,905	D42E	probably benign	Het
Lrrc14b	A	G	13: 74,361,160	M376T	probably benign	Het
Lrrc40	A	G	3: 158,054,564		probably null	Het
Ltv1	T	C	10: 13,192,143	T34A	probably benign	Het
Mga	T	A	2: 119,916,488	N373K	probably damaging	Het
Msh3	A	T	13: 92,220,997	M101K	probably damaging	Het
Mthfd2l	T	C	5: 91,020,206	M320T	possibly damaging	Het
Mug1	G	A	6: 121,861,555	E506K	probably benign	Het
Ngb	T	C	12: 87,100,729	D54G	probably damaging	Het
Ntrk1	A	G	3: 87,791,707	F84L	probably benign	Het
Olfr347	A	T	2: 36,734,533	I71F	probably benign	Het
Olfr667	T	A	7: 104,916,973	T108S	probably benign	Het
Phf12	T	A	11: 78,018,168	I358N	possibly damaging	Het
Plec	A	G	15: 76,177,601	F2577S	probably damaging	Het
Polr1c	T	A	17: 46,247,763	Y36F	probably benign	Het
Prkd1	A	T	12: 50,366,372	M672K	probably damaging	Het
Prob1	T	C	18: 35,652,486	Y905C	probably damaging	Het
Ptpn23	T	A	9: 110,386,293	H1433L	possibly damaging	Het
Rnf11	A	T	4: 109,456,952	L80Q	probably damaging	Het
Sbp	G	A	17: 23,945,312	G183D	probably benign	Het
Scgb2b7	A	T	7: 31,704,012	C90S	possibly damaging	Het
Slc4a9	T	C	18: 36,535,418	L710P	probably damaging	Het
Spire1	T	A	18: 67,552,600	I35F	probably damaging	Het
Sptbn2	T	C	19: 4,745,938	V1715A	possibly damaging	Het
St7	T	C	6: 17,819,282	F62L	probably damaging	Het
Svep1	C	T	4: 58,118,136	G862D	probably damaging	Het
Syne1	A	T	10: 5,022,041	M8789K	probably damaging	Het
Synpo2	A	G	3: 123,112,772	L965P	probably damaging	Het
Trhde	A	T	10: 114,448,262	M772K	probably benign	Het
Ttn	T	A	2: 76,778,507	K15976*	probably null	Het
Unc13a	A	C	8: 71,658,001		probably null	Het
Vcan	T	C	13: 89,703,199	E1214G	possibly damaging	Het
Vmn1r60	T	A	7: 5,545,119		probably benign	Het
Wdr90	C	T	17: 25,860,485	R225H	probably benign	Het
Wnk1	G	A	6: 119,969,332	T620I	probably damaging	Het
Zan	C	T	5: 137,407,706		probably benign	Het
Zfp37	A	T	4: 62,191,665	C387*	probably null	Het
Zfp521	T	C	18: 13,844,840	T839A	probably benign	Het

Other mutations in Vmn1r29

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02504:Vmn1r29	APN	6	58307670	missense	probably benign	0.03
IGL03351:Vmn1r29	APN	6	58307750	missense	probably damaging	1.00
R0594:Vmn1r29	UTSW	6	58307772	missense	probably benign	0.35
R0735:Vmn1r29	UTSW	6	58307732	missense	probably damaging	0.96
R1422:Vmn1r29	UTSW	6	58307886	missense	probably damaging	1.00
R1476:Vmn1r29	UTSW	6	58307678	missense	probably benign	0.23
R1679:Vmn1r29	UTSW	6	58308018	missense	probably damaging	1.00
R1831:Vmn1r29	UTSW	6	58307707	nonsense	probably null
R1925:Vmn1r29	UTSW	6	58308102	missense	possibly damaging	0.79
R1933:Vmn1r29	UTSW	6	58307420	missense	probably benign	0.03
R4582:Vmn1r29	UTSW	6	58308032	missense	probably damaging	0.98
R4677:Vmn1r29	UTSW	6	58307300	missense	probably benign	0.02
R4706:Vmn1r29	UTSW	6	58308151	missense	probably benign	0.00
R5023:Vmn1r29	UTSW	6	58308067	nonsense	probably null
R5542:Vmn1r29	UTSW	6	58308123	missense	probably benign	0.14
R5649:Vmn1r29	UTSW	6	58307691	missense	probably benign	0.13
R5656:Vmn1r29	UTSW	6	58308167	missense	possibly damaging	0.94
R5906:Vmn1r29	UTSW	6	58307751	missense	probably benign	0.19
R6078:Vmn1r29	UTSW	6	58308095	missense	probably benign	0.01
R6349:Vmn1r29	UTSW	6	58307427	missense	probably damaging	1.00
R7946:Vmn1r29	UTSW	6	58307849	missense	probably benign	0.18
R8554:Vmn1r29	UTSW	6	58308206	makesense	probably null
R8944:Vmn1r29	UTSW	6	58307289	start gained	probably benign
R8955:Vmn1r29	UTSW	6	58307299	start codon destroyed	probably null	1.00
R9268:Vmn1r29	UTSW	6	58307592	missense	probably damaging	1.00
RF020:Vmn1r29	UTSW	6	58307543	missense	probably benign	0.01
U15987:Vmn1r29	UTSW	6	58308095	missense	probably benign	0.01

Predicted Primers

PCR Primer
(F):5'- GAGGCAATGCAAGCATCTTCATAGC -3'
(R):5'- TCTTCTTACCTCTGTGGGCACTAGG -3'

Sequencing Primer
(F):5'- TAGCATCAGCTATCTGAGAGCATC -3'
(R):5'- CCTCTGTGGGCACTAGGAATATAC -3'

Posted On

2013-05-23