Incidental Mutation 'IGL03180:Grip2'
ID 412212
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Grip2
Ensembl Gene ENSMUSG00000030098
Gene Name glutamate receptor interacting protein 2
Synonyms
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03180
Quality Score
Status
Chromosome 6
Chromosomal Location 91738490-91804231 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 91762742 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000124709 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159684] [ENSMUST00000161566] [ENSMUST00000162293] [ENSMUST00000162300]
AlphaFold G3XA20
Predicted Effect probably benign
Transcript: ENSMUST00000159684
SMART Domains Protein: ENSMUSP00000125047
Gene: ENSMUSG00000030098

DomainStartEndE-ValueType
low complexity region 25 36 N/A INTRINSIC
PDZ 62 136 1.12e-12 SMART
PDZ 161 239 3.8e-15 SMART
PDZ 262 337 7.9e-13 SMART
low complexity region 385 390 N/A INTRINSIC
PDZ 426 506 2.18e-15 SMART
PDZ 527 602 3.86e-16 SMART
PDZ 625 699 1.38e-17 SMART
low complexity region 778 793 N/A INTRINSIC
low complexity region 867 878 N/A INTRINSIC
PDZ 910 982 2.95e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161545
SMART Domains Protein: ENSMUSP00000125538
Gene: ENSMUSG00000030098

DomainStartEndE-ValueType
low complexity region 22 33 N/A INTRINSIC
PDB:2QT5|B 42 89 3e-9 PDB
SCOP:d1lcya1 47 89 2e-7 SMART
low complexity region 103 119 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161566
SMART Domains Protein: ENSMUSP00000123941
Gene: ENSMUSG00000030098

DomainStartEndE-ValueType
low complexity region 25 36 N/A INTRINSIC
PDZ 62 136 9.96e-10 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162293
SMART Domains Protein: ENSMUSP00000124717
Gene: ENSMUSG00000030098

DomainStartEndE-ValueType
PDZ 10 84 1.12e-12 SMART
PDZ 109 187 3.8e-15 SMART
PDZ 210 285 7.9e-13 SMART
low complexity region 336 348 N/A INTRINSIC
low complexity region 374 379 N/A INTRINSIC
PDZ 415 495 2.18e-15 SMART
PDZ 516 591 3.86e-16 SMART
PDZ 614 688 1.38e-17 SMART
low complexity region 767 782 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162300
SMART Domains Protein: ENSMUSP00000124709
Gene: ENSMUSG00000030098

DomainStartEndE-ValueType
low complexity region 25 36 N/A INTRINSIC
PDZ 62 136 1.12e-12 SMART
PDZ 161 239 3.8e-15 SMART
PDZ 262 337 7.9e-13 SMART
low complexity region 388 400 N/A INTRINSIC
low complexity region 426 431 N/A INTRINSIC
PDZ 467 547 2.18e-15 SMART
PDZ 568 643 3.86e-16 SMART
PDZ 666 740 1.38e-17 SMART
low complexity region 819 834 N/A INTRINSIC
low complexity region 908 919 N/A INTRINSIC
PDZ 951 1023 2.95e-12 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice are born in numbers expected by the Mendelian ratio and show no overt phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp6 T C 3: 97,082,951 (GRCm39) Y321H probably benign Het
Adam28 T A 14: 68,874,883 (GRCm39) I265L probably damaging Het
Adcy8 T C 15: 64,655,799 (GRCm39) D560G possibly damaging Het
Aff3 A G 1: 38,574,743 (GRCm39) M79T probably damaging Het
Ahctf1 A G 1: 179,602,895 (GRCm39) probably null Het
Aspn C T 13: 49,716,991 (GRCm39) R256W probably damaging Het
Birc6 T C 17: 74,966,226 (GRCm39) V4051A probably benign Het
Cfap46 G A 7: 139,183,168 (GRCm39) L2584F unknown Het
Chdh T A 14: 29,756,559 (GRCm39) probably null Het
Clasp1 A G 1: 118,433,255 (GRCm39) T245A probably benign Het
Clec4a1 G A 6: 122,901,777 (GRCm39) V70I probably benign Het
Cpt2 A T 4: 107,764,157 (GRCm39) S536T probably damaging Het
Dnah9 A T 11: 65,777,465 (GRCm39) H3694Q probably damaging Het
Dntt T A 19: 41,017,990 (GRCm39) F38Y probably benign Het
Dync2i1 T C 12: 116,182,485 (GRCm39) S706G probably benign Het
Eif4ebp2 T C 10: 61,269,589 (GRCm39) E117G probably damaging Het
Eif5b T C 1: 38,075,350 (GRCm39) I609T probably damaging Het
Esam G A 9: 37,445,866 (GRCm39) G135S probably damaging Het
Fut7 C A 2: 25,315,465 (GRCm39) A241D possibly damaging Het
Grin2d T A 7: 45,502,753 (GRCm39) K706M probably damaging Het
Gtf2ird2 A G 5: 134,220,087 (GRCm39) T22A probably damaging Het
Hadh T C 3: 131,065,533 (GRCm39) I42V probably benign Het
Iqsec3 T A 6: 121,390,467 (GRCm39) probably benign Het
Izumo3 G A 4: 92,034,524 (GRCm39) probably benign Het
Ldlrad1 G T 4: 107,075,032 (GRCm39) C193F probably damaging Het
Lgals4 G A 7: 28,537,053 (GRCm39) G118R probably damaging Het
Map4k1 A C 7: 28,687,510 (GRCm39) E136A probably damaging Het
Mapk8ip1 G T 2: 92,217,257 (GRCm39) P346Q possibly damaging Het
Mrtfb A G 16: 13,216,196 (GRCm39) K303E probably damaging Het
Nlrp14 T A 7: 106,781,833 (GRCm39) H343Q probably benign Het
Ogg1 T G 6: 113,310,455 (GRCm39) probably null Het
Or12k8 C T 2: 36,975,722 (GRCm39) V13M possibly damaging Het
Or5m10 A T 2: 85,717,740 (GRCm39) M199L probably benign Het
Pacc1 G T 1: 191,071,089 (GRCm39) V82F probably damaging Het
Pafah1b1 A T 11: 74,574,344 (GRCm39) C281S possibly damaging Het
Papss1 C T 3: 131,313,143 (GRCm39) R386W probably damaging Het
Pex5 A G 6: 124,390,522 (GRCm39) probably benign Het
Pibf1 C A 14: 99,370,780 (GRCm39) Q261K probably benign Het
Plcb3 T C 19: 6,933,521 (GRCm39) S935G probably benign Het
Polg A G 7: 79,101,601 (GRCm39) probably benign Het
Ptpdc1 G A 13: 48,739,553 (GRCm39) T626I probably damaging Het
Rab34 A T 11: 78,081,144 (GRCm39) Y87F probably damaging Het
Rsrc1 T G 3: 66,989,876 (GRCm39) probably benign Het
Ryr2 T C 13: 11,583,449 (GRCm39) N4735S possibly damaging Het
Scn7a T C 2: 66,506,578 (GRCm39) D1437G possibly damaging Het
Sdk1 A G 5: 142,071,497 (GRCm39) E1229G probably damaging Het
Sez6l A T 5: 112,584,151 (GRCm39) V806D probably damaging Het
Sgsm2 A C 11: 74,759,401 (GRCm39) probably null Het
Sla A G 15: 66,661,569 (GRCm39) I121T probably benign Het
Son T C 16: 91,453,896 (GRCm39) L881S probably damaging Het
Srms A G 2: 180,854,573 (GRCm39) probably benign Het
Stoml1 T C 9: 58,168,200 (GRCm39) S304P probably damaging Het
Stt3a T C 9: 36,670,552 (GRCm39) D73G probably damaging Het
Tpp1 T C 7: 105,395,856 (GRCm39) T558A probably benign Het
Trp53i13 T C 11: 77,403,528 (GRCm39) probably benign Het
Vmn2r77 A G 7: 86,450,843 (GRCm39) Y243C possibly damaging Het
Vwde T C 6: 13,205,764 (GRCm39) D261G probably damaging Het
Zfpm2 A G 15: 40,964,790 (GRCm39) K293R probably damaging Het
Other mutations in Grip2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01141:Grip2 APN 6 91,759,878 (GRCm39) missense probably benign 0.00
IGL01748:Grip2 APN 6 91,741,724 (GRCm39) missense probably damaging 1.00
IGL01838:Grip2 APN 6 91,741,744 (GRCm39) missense possibly damaging 0.92
IGL02392:Grip2 APN 6 91,764,276 (GRCm39) missense probably damaging 1.00
IGL02620:Grip2 APN 6 91,755,587 (GRCm39) missense possibly damaging 0.93
IGL02862:Grip2 APN 6 91,765,085 (GRCm39) missense probably damaging 0.98
IGL03027:Grip2 APN 6 91,755,852 (GRCm39) missense probably benign 0.02
R0265:Grip2 UTSW 6 91,750,773 (GRCm39) critical splice donor site probably null
R0448:Grip2 UTSW 6 91,756,194 (GRCm39) missense probably damaging 1.00
R0597:Grip2 UTSW 6 91,773,178 (GRCm39) intron probably benign
R1405:Grip2 UTSW 6 91,765,133 (GRCm39) splice site probably null
R1405:Grip2 UTSW 6 91,765,133 (GRCm39) splice site probably null
R1466:Grip2 UTSW 6 91,765,424 (GRCm39) missense probably damaging 0.98
R1466:Grip2 UTSW 6 91,765,424 (GRCm39) missense probably damaging 0.98
R1664:Grip2 UTSW 6 91,742,233 (GRCm39) missense probably damaging 1.00
R1703:Grip2 UTSW 6 91,754,379 (GRCm39) missense probably damaging 1.00
R1793:Grip2 UTSW 6 91,760,623 (GRCm39) missense probably benign 0.03
R1951:Grip2 UTSW 6 91,760,829 (GRCm39) missense probably damaging 1.00
R2001:Grip2 UTSW 6 91,756,831 (GRCm39) missense probably benign 0.00
R4730:Grip2 UTSW 6 91,762,693 (GRCm39) makesense probably null
R4754:Grip2 UTSW 6 91,756,173 (GRCm39) missense probably damaging 0.97
R4754:Grip2 UTSW 6 91,756,163 (GRCm39) missense probably damaging 1.00
R4773:Grip2 UTSW 6 91,759,413 (GRCm39) missense possibly damaging 0.80
R5135:Grip2 UTSW 6 91,750,897 (GRCm39) missense possibly damaging 0.89
R5213:Grip2 UTSW 6 91,756,812 (GRCm39) missense probably benign 0.04
R5972:Grip2 UTSW 6 91,784,262 (GRCm39) missense probably benign 0.01
R6176:Grip2 UTSW 6 91,756,832 (GRCm39) missense probably benign 0.00
R6188:Grip2 UTSW 6 91,740,514 (GRCm39) missense probably damaging 1.00
R6289:Grip2 UTSW 6 91,755,852 (GRCm39) missense probably benign 0.02
R6345:Grip2 UTSW 6 91,742,369 (GRCm39) missense possibly damaging 0.91
R6348:Grip2 UTSW 6 91,757,419 (GRCm39) missense probably damaging 0.99
R6394:Grip2 UTSW 6 91,764,182 (GRCm39) missense probably damaging 1.00
R6658:Grip2 UTSW 6 91,763,472 (GRCm39) missense probably damaging 1.00
R7065:Grip2 UTSW 6 91,760,550 (GRCm39) critical splice donor site probably null
R7074:Grip2 UTSW 6 91,761,689 (GRCm39) missense probably benign 0.24
R7308:Grip2 UTSW 6 91,755,669 (GRCm39) missense possibly damaging 0.74
R7607:Grip2 UTSW 6 91,765,393 (GRCm39) missense probably benign
R7617:Grip2 UTSW 6 91,742,031 (GRCm39) splice site probably null
R7970:Grip2 UTSW 6 91,763,513 (GRCm39) missense probably benign 0.07
R8221:Grip2 UTSW 6 91,762,665 (GRCm39) missense possibly damaging 0.90
R8549:Grip2 UTSW 6 91,750,769 (GRCm39) splice site probably null
R8838:Grip2 UTSW 6 91,762,721 (GRCm39) utr 3 prime probably benign
R8962:Grip2 UTSW 6 91,754,391 (GRCm39) missense probably damaging 1.00
R9430:Grip2 UTSW 6 91,784,265 (GRCm39) missense probably benign 0.05
R9699:Grip2 UTSW 6 91,742,318 (GRCm39) missense probably benign
R9732:Grip2 UTSW 6 91,761,686 (GRCm39) missense probably damaging 0.99
RF003:Grip2 UTSW 6 91,760,574 (GRCm39) missense probably benign 0.02
Z1176:Grip2 UTSW 6 91,740,491 (GRCm39) missense possibly damaging 0.55
Posted On 2016-08-02