Incidental Mutation 'IGL03181:Drc7'
ID 412228
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Drc7
Ensembl Gene ENSMUSG00000031786
Gene Name dynein regulatory complex subunit 7
Synonyms Ccdc135, SRG-L, LOC330830
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03181
Quality Score
Status
Chromosome 8
Chromosomal Location 95781731-95804769 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 95794755 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 387 (T387A)
Ref Sequence ENSEMBL: ENSMUSP00000053972 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058479]
AlphaFold Q6V3W6
Predicted Effect probably benign
Transcript: ENSMUST00000058479
AA Change: T387A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000053972
Gene: ENSMUSG00000031786
AA Change: T387A

DomainStartEndE-ValueType
coiled coil region 1 33 N/A INTRINSIC
low complexity region 229 246 N/A INTRINSIC
coiled coil region 258 295 N/A INTRINSIC
low complexity region 388 411 N/A INTRINSIC
low complexity region 544 555 N/A INTRINSIC
low complexity region 695 710 N/A INTRINSIC
low complexity region 798 809 N/A INTRINSIC
low complexity region 848 864 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T C 12: 71,240,147 (GRCm39) V1319A possibly damaging Het
Abcb11 T A 2: 69,158,352 (GRCm39) probably benign Het
Acss3 G T 10: 106,889,249 (GRCm39) H190Q probably damaging Het
Adra2b C T 2: 127,205,903 (GRCm39) T140I probably benign Het
Arl1 T A 10: 88,578,921 (GRCm39) probably benign Het
Atp4a T G 7: 30,424,129 (GRCm39) C968G probably benign Het
Clec4n T C 6: 123,207,474 (GRCm39) C13R possibly damaging Het
Cnot3 T C 7: 3,656,247 (GRCm39) Y178H probably damaging Het
Col18a1 G A 10: 76,891,532 (GRCm39) R1560C probably damaging Het
Cyp2c66 T C 19: 39,130,483 (GRCm39) F106S probably benign Het
Dcn A C 10: 97,319,314 (GRCm39) E30D probably damaging Het
Dennd5a A T 7: 109,532,865 (GRCm39) F302I probably damaging Het
Dip2b T C 15: 100,113,088 (GRCm39) V1501A probably damaging Het
Dnah10 C T 5: 124,825,521 (GRCm39) P687S probably damaging Het
Dusp7 T A 9: 106,251,009 (GRCm39) M378K probably damaging Het
Ftmt T C 18: 52,464,953 (GRCm39) Y90H probably damaging Het
Glb1l3 T C 9: 26,739,659 (GRCm39) probably null Het
Gpatch3 T C 4: 133,305,433 (GRCm39) F223L probably damaging Het
Gpr158 T A 2: 21,787,972 (GRCm39) F538I probably benign Het
Gucy2e A G 11: 69,121,008 (GRCm39) probably benign Het
Hadha A G 5: 30,326,524 (GRCm39) V566A probably benign Het
Hectd4 A T 5: 121,492,021 (GRCm39) S3787C possibly damaging Het
Hnrnpk A T 13: 58,542,130 (GRCm39) D265E possibly damaging Het
Hspbp1 G A 7: 4,687,363 (GRCm39) R83W probably damaging Het
Hspg2 T A 4: 137,243,248 (GRCm39) L758Q probably damaging Het
Ippk A G 13: 49,595,463 (GRCm39) Y180C probably damaging Het
Itpr3 T A 17: 27,330,242 (GRCm39) M1620K probably benign Het
Klf7 T C 1: 64,074,885 (GRCm39) K298R possibly damaging Het
Ktn1 A T 14: 47,970,741 (GRCm39) T1229S probably benign Het
Lefty2 A G 1: 180,725,115 (GRCm39) N282D probably damaging Het
Lrrc37 A T 11: 103,507,242 (GRCm39) probably benign Het
Nsd1 G A 13: 55,394,858 (GRCm39) E820K probably damaging Het
Obsl1 C A 1: 75,469,228 (GRCm39) A1238S probably benign Het
Odr4 G T 1: 150,239,290 (GRCm39) P378T probably benign Het
Pias2 T C 18: 77,220,938 (GRCm39) I391T possibly damaging Het
Ppp1r10 G T 17: 36,241,516 (GRCm39) G764* probably null Het
Ptpra T C 2: 130,359,707 (GRCm39) F158L probably damaging Het
Recql T C 6: 142,323,918 (GRCm39) S59G probably benign Het
Rrp1b A T 17: 32,276,150 (GRCm39) I566F probably benign Het
Sh3yl1 G A 12: 30,991,979 (GRCm39) D145N possibly damaging Het
Slc35f5 T A 1: 125,512,922 (GRCm39) I52N probably damaging Het
Slc51b A G 9: 65,322,447 (GRCm39) probably null Het
Smpd4 C T 16: 17,443,671 (GRCm39) Q72* probably null Het
Spata6 A G 4: 111,679,963 (GRCm39) D391G probably benign Het
Tnc T A 4: 63,885,543 (GRCm39) D1853V possibly damaging Het
Tnks1bp1 C T 2: 84,893,058 (GRCm39) T333I probably benign Het
Vmn2r100 T A 17: 19,752,207 (GRCm39) I813N probably damaging Het
Vwa8 T A 14: 79,246,690 (GRCm39) H677Q probably benign Het
Washc4 T C 10: 83,426,883 (GRCm39) Y1064H probably damaging Het
Wdr82 T A 9: 106,063,614 (GRCm39) I272K probably benign Het
Zc3h12a T C 4: 125,013,097 (GRCm39) Y589C probably damaging Het
Other mutations in Drc7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00340:Drc7 APN 8 95,782,629 (GRCm39) splice site probably benign
IGL00922:Drc7 APN 8 95,804,606 (GRCm39) missense probably benign 0.00
IGL01610:Drc7 APN 8 95,804,430 (GRCm39) missense probably damaging 1.00
IGL01642:Drc7 APN 8 95,785,767 (GRCm39) missense probably benign 0.34
IGL01793:Drc7 APN 8 95,797,905 (GRCm39) missense probably benign 0.25
IGL01936:Drc7 APN 8 95,800,760 (GRCm39) missense possibly damaging 0.89
IGL01953:Drc7 APN 8 95,785,753 (GRCm39) missense probably damaging 1.00
IGL01998:Drc7 APN 8 95,785,821 (GRCm39) missense probably damaging 1.00
IGL02237:Drc7 APN 8 95,799,507 (GRCm39) missense probably damaging 1.00
IGL02259:Drc7 APN 8 95,782,733 (GRCm39) missense probably benign
IGL02285:Drc7 APN 8 95,797,861 (GRCm39) splice site probably benign
IGL02940:Drc7 APN 8 95,800,925 (GRCm39) missense probably damaging 0.99
IGL03032:Drc7 APN 8 95,802,875 (GRCm39) splice site probably benign
R0018:Drc7 UTSW 8 95,800,862 (GRCm39) missense probably damaging 0.99
R0018:Drc7 UTSW 8 95,800,862 (GRCm39) missense probably damaging 0.99
R0281:Drc7 UTSW 8 95,797,881 (GRCm39) missense possibly damaging 0.61
R0304:Drc7 UTSW 8 95,785,756 (GRCm39) missense probably damaging 1.00
R0362:Drc7 UTSW 8 95,799,483 (GRCm39) missense probably benign 0.00
R1127:Drc7 UTSW 8 95,799,416 (GRCm39) missense probably damaging 0.98
R1635:Drc7 UTSW 8 95,800,960 (GRCm39) critical splice donor site probably null
R1921:Drc7 UTSW 8 95,782,644 (GRCm39) missense unknown
R1931:Drc7 UTSW 8 95,797,881 (GRCm39) missense possibly damaging 0.61
R2256:Drc7 UTSW 8 95,801,637 (GRCm39) missense probably benign 0.16
R3851:Drc7 UTSW 8 95,788,464 (GRCm39) nonsense probably null
R4797:Drc7 UTSW 8 95,800,925 (GRCm39) missense probably damaging 0.96
R4827:Drc7 UTSW 8 95,798,267 (GRCm39) missense probably damaging 0.98
R4966:Drc7 UTSW 8 95,798,224 (GRCm39) missense probably benign 0.45
R5194:Drc7 UTSW 8 95,788,345 (GRCm39) missense probably benign 0.00
R5721:Drc7 UTSW 8 95,800,961 (GRCm39) critical splice donor site probably null
R5911:Drc7 UTSW 8 95,800,754 (GRCm39) missense probably damaging 1.00
R5993:Drc7 UTSW 8 95,800,820 (GRCm39) missense probably benign
R6056:Drc7 UTSW 8 95,801,679 (GRCm39) missense probably damaging 1.00
R6534:Drc7 UTSW 8 95,797,910 (GRCm39) missense probably damaging 1.00
R6576:Drc7 UTSW 8 95,801,886 (GRCm39) missense probably damaging 0.98
R6861:Drc7 UTSW 8 95,789,025 (GRCm39) critical splice donor site probably null
R7104:Drc7 UTSW 8 95,785,711 (GRCm39) missense probably damaging 0.99
R7157:Drc7 UTSW 8 95,800,778 (GRCm39) missense probably damaging 0.99
R7205:Drc7 UTSW 8 95,804,549 (GRCm39) missense probably damaging 1.00
R7283:Drc7 UTSW 8 95,798,207 (GRCm39) missense probably damaging 0.99
R7351:Drc7 UTSW 8 95,785,135 (GRCm39) missense probably benign 0.25
R7567:Drc7 UTSW 8 95,794,684 (GRCm39) missense probably benign 0.00
R8211:Drc7 UTSW 8 95,782,707 (GRCm39) missense unknown
R8281:Drc7 UTSW 8 95,788,805 (GRCm39) missense possibly damaging 0.81
R8401:Drc7 UTSW 8 95,800,763 (GRCm39) missense probably benign
R8821:Drc7 UTSW 8 95,788,845 (GRCm39) missense probably damaging 1.00
R8831:Drc7 UTSW 8 95,788,845 (GRCm39) missense probably damaging 1.00
R9044:Drc7 UTSW 8 95,797,077 (GRCm39) missense probably damaging 0.98
R9326:Drc7 UTSW 8 95,801,886 (GRCm39) missense probably benign 0.02
R9565:Drc7 UTSW 8 95,801,866 (GRCm39) missense probably damaging 0.98
R9581:Drc7 UTSW 8 95,785,782 (GRCm39) missense probably damaging 0.98
Y5404:Drc7 UTSW 8 95,794,778 (GRCm39) small deletion probably benign
Posted On 2016-08-02