Incidental Mutation 'IGL03181:Odr4'
ID 412243
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Odr4
Ensembl Gene ENSMUSG00000006010
Gene Name odr4 GPCR localization factor homolog
Synonyms BC003331, 1810053E15Rik
Accession Numbers
Essential gene? Possibly essential (E-score: 0.746) question?
Stock # IGL03181
Quality Score
Status
Chromosome 1
Chromosomal Location 150237056-150268831 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 150239290 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 378 (P378T)
Ref Sequence ENSEMBL: ENSMUSP00000095153 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006167] [ENSMUST00000094477] [ENSMUST00000097546] [ENSMUST00000097547] [ENSMUST00000111913]
AlphaFold Q4PJX1
Predicted Effect probably benign
Transcript: ENSMUST00000006167
AA Change: P388T

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000006167
Gene: ENSMUSG00000006010
AA Change: P388T

DomainStartEndE-ValueType
Pfam:ODR4-like 28 364 1.8e-107 PFAM
transmembrane domain 402 424 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000094477
SMART Domains Protein: ENSMUSP00000092050
Gene: ENSMUSG00000006010

DomainStartEndE-ValueType
Pfam:ODR4-like 28 383 2.8e-120 PFAM
transmembrane domain 424 446 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000097546
AA Change: P388T

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000095152
Gene: ENSMUSG00000006010
AA Change: P388T

DomainStartEndE-ValueType
Pfam:ODR4-like 28 364 1.8e-107 PFAM
transmembrane domain 402 424 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000097547
AA Change: P378T

PolyPhen 2 Score 0.056 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000095153
Gene: ENSMUSG00000006010
AA Change: P378T

DomainStartEndE-ValueType
Pfam:ODR4-like 28 209 1.2e-57 PFAM
Pfam:ODR4-like 206 354 3.1e-43 PFAM
transmembrane domain 392 414 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000111913
AA Change: P410T

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000107544
Gene: ENSMUSG00000006010
AA Change: P410T

DomainStartEndE-ValueType
Pfam:ODR4-like 28 386 7.1e-113 PFAM
transmembrane domain 424 446 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T C 12: 71,240,147 (GRCm39) V1319A possibly damaging Het
Abcb11 T A 2: 69,158,352 (GRCm39) probably benign Het
Acss3 G T 10: 106,889,249 (GRCm39) H190Q probably damaging Het
Adra2b C T 2: 127,205,903 (GRCm39) T140I probably benign Het
Arl1 T A 10: 88,578,921 (GRCm39) probably benign Het
Atp4a T G 7: 30,424,129 (GRCm39) C968G probably benign Het
Clec4n T C 6: 123,207,474 (GRCm39) C13R possibly damaging Het
Cnot3 T C 7: 3,656,247 (GRCm39) Y178H probably damaging Het
Col18a1 G A 10: 76,891,532 (GRCm39) R1560C probably damaging Het
Cyp2c66 T C 19: 39,130,483 (GRCm39) F106S probably benign Het
Dcn A C 10: 97,319,314 (GRCm39) E30D probably damaging Het
Dennd5a A T 7: 109,532,865 (GRCm39) F302I probably damaging Het
Dip2b T C 15: 100,113,088 (GRCm39) V1501A probably damaging Het
Dnah10 C T 5: 124,825,521 (GRCm39) P687S probably damaging Het
Drc7 A G 8: 95,794,755 (GRCm39) T387A probably benign Het
Dusp7 T A 9: 106,251,009 (GRCm39) M378K probably damaging Het
Ftmt T C 18: 52,464,953 (GRCm39) Y90H probably damaging Het
Glb1l3 T C 9: 26,739,659 (GRCm39) probably null Het
Gpatch3 T C 4: 133,305,433 (GRCm39) F223L probably damaging Het
Gpr158 T A 2: 21,787,972 (GRCm39) F538I probably benign Het
Gucy2e A G 11: 69,121,008 (GRCm39) probably benign Het
Hadha A G 5: 30,326,524 (GRCm39) V566A probably benign Het
Hectd4 A T 5: 121,492,021 (GRCm39) S3787C possibly damaging Het
Hnrnpk A T 13: 58,542,130 (GRCm39) D265E possibly damaging Het
Hspbp1 G A 7: 4,687,363 (GRCm39) R83W probably damaging Het
Hspg2 T A 4: 137,243,248 (GRCm39) L758Q probably damaging Het
Ippk A G 13: 49,595,463 (GRCm39) Y180C probably damaging Het
Itpr3 T A 17: 27,330,242 (GRCm39) M1620K probably benign Het
Klf7 T C 1: 64,074,885 (GRCm39) K298R possibly damaging Het
Ktn1 A T 14: 47,970,741 (GRCm39) T1229S probably benign Het
Lefty2 A G 1: 180,725,115 (GRCm39) N282D probably damaging Het
Lrrc37 A T 11: 103,507,242 (GRCm39) probably benign Het
Nsd1 G A 13: 55,394,858 (GRCm39) E820K probably damaging Het
Obsl1 C A 1: 75,469,228 (GRCm39) A1238S probably benign Het
Pias2 T C 18: 77,220,938 (GRCm39) I391T possibly damaging Het
Ppp1r10 G T 17: 36,241,516 (GRCm39) G764* probably null Het
Ptpra T C 2: 130,359,707 (GRCm39) F158L probably damaging Het
Recql T C 6: 142,323,918 (GRCm39) S59G probably benign Het
Rrp1b A T 17: 32,276,150 (GRCm39) I566F probably benign Het
Sh3yl1 G A 12: 30,991,979 (GRCm39) D145N possibly damaging Het
Slc35f5 T A 1: 125,512,922 (GRCm39) I52N probably damaging Het
Slc51b A G 9: 65,322,447 (GRCm39) probably null Het
Smpd4 C T 16: 17,443,671 (GRCm39) Q72* probably null Het
Spata6 A G 4: 111,679,963 (GRCm39) D391G probably benign Het
Tnc T A 4: 63,885,543 (GRCm39) D1853V possibly damaging Het
Tnks1bp1 C T 2: 84,893,058 (GRCm39) T333I probably benign Het
Vmn2r100 T A 17: 19,752,207 (GRCm39) I813N probably damaging Het
Vwa8 T A 14: 79,246,690 (GRCm39) H677Q probably benign Het
Washc4 T C 10: 83,426,883 (GRCm39) Y1064H probably damaging Het
Wdr82 T A 9: 106,063,614 (GRCm39) I272K probably benign Het
Zc3h12a T C 4: 125,013,097 (GRCm39) Y589C probably damaging Het
Other mutations in Odr4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01876:Odr4 APN 1 150,258,089 (GRCm39) missense probably benign 0.10
IGL02189:Odr4 APN 1 150,247,784 (GRCm39) missense possibly damaging 0.94
IGL02257:Odr4 APN 1 150,262,155 (GRCm39) missense probably damaging 0.99
IGL02485:Odr4 APN 1 150,239,240 (GRCm39) critical splice donor site probably null
IGL02585:Odr4 APN 1 150,239,272 (GRCm39) missense probably damaging 0.96
IGL02712:Odr4 APN 1 150,262,107 (GRCm39) critical splice donor site probably null
IGL02902:Odr4 APN 1 150,260,179 (GRCm39) critical splice donor site probably null
IGL03014:Odr4 APN 1 150,258,804 (GRCm39) splice site probably benign
IGL03124:Odr4 APN 1 150,262,176 (GRCm39) missense probably benign 0.00
IGL03344:Odr4 APN 1 150,239,295 (GRCm39) missense probably damaging 0.99
R1170:Odr4 UTSW 1 150,262,142 (GRCm39) missense probably benign 0.00
R1796:Odr4 UTSW 1 150,251,305 (GRCm39) missense probably benign
R1902:Odr4 UTSW 1 150,264,360 (GRCm39) splice site probably null
R2149:Odr4 UTSW 1 150,264,310 (GRCm39) missense probably benign 0.05
R2155:Odr4 UTSW 1 150,258,086 (GRCm39) missense possibly damaging 0.68
R2375:Odr4 UTSW 1 150,265,985 (GRCm39) critical splice donor site probably null
R3786:Odr4 UTSW 1 150,260,282 (GRCm39) missense probably benign 0.21
R3948:Odr4 UTSW 1 150,264,308 (GRCm39) nonsense probably null
R4589:Odr4 UTSW 1 150,260,238 (GRCm39) missense probably benign 0.11
R4590:Odr4 UTSW 1 150,262,103 (GRCm39) splice site probably null
R4815:Odr4 UTSW 1 150,250,597 (GRCm39) missense probably damaging 0.99
R5196:Odr4 UTSW 1 150,258,140 (GRCm39) missense probably damaging 1.00
R5437:Odr4 UTSW 1 150,239,269 (GRCm39) missense probably benign 0.01
R5549:Odr4 UTSW 1 150,247,909 (GRCm39) missense possibly damaging 0.86
R5677:Odr4 UTSW 1 150,250,588 (GRCm39) missense probably damaging 1.00
R5896:Odr4 UTSW 1 150,256,111 (GRCm39) missense probably benign 0.10
R6472:Odr4 UTSW 1 150,257,273 (GRCm39) missense probably benign 0.15
R7108:Odr4 UTSW 1 150,258,041 (GRCm39) missense probably benign 0.01
R7402:Odr4 UTSW 1 150,262,107 (GRCm39) critical splice donor site probably null
R7662:Odr4 UTSW 1 150,258,045 (GRCm39) missense probably benign
R7767:Odr4 UTSW 1 150,247,788 (GRCm39) missense probably benign 0.00
R7810:Odr4 UTSW 1 150,268,659 (GRCm39) utr 5 prime probably benign
R7916:Odr4 UTSW 1 150,260,249 (GRCm39) missense probably benign 0.01
R8114:Odr4 UTSW 1 150,264,308 (GRCm39) nonsense probably null
R8120:Odr4 UTSW 1 150,260,177 (GRCm39) splice site probably null
R8435:Odr4 UTSW 1 150,258,020 (GRCm39) missense possibly damaging 0.90
R9397:Odr4 UTSW 1 150,238,616 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02