Incidental Mutation 'IGL03181:Cyp2c66'
ID 412248
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp2c66
Ensembl Gene ENSMUSG00000067229
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms 2010301M18Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # IGL03181
Quality Score
Status
Chromosome 19
Chromosomal Location 39102342-39175200 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 39130483 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 106 (F106S)
Ref Sequence ENSEMBL: ENSMUSP00000084487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087234] [ENSMUST00000146494]
AlphaFold Q5GLZ0
Predicted Effect probably benign
Transcript: ENSMUST00000087234
AA Change: F106S

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000084487
Gene: ENSMUSG00000067229
AA Change: F106S

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 30 487 1e-157 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000146494
SMART Domains Protein: ENSMUSP00000120397
Gene: ENSMUSG00000067229

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
SCOP:d1cpt__ 26 55 4e-9 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T C 12: 71,240,147 (GRCm39) V1319A possibly damaging Het
Abcb11 T A 2: 69,158,352 (GRCm39) probably benign Het
Acss3 G T 10: 106,889,249 (GRCm39) H190Q probably damaging Het
Adra2b C T 2: 127,205,903 (GRCm39) T140I probably benign Het
Arl1 T A 10: 88,578,921 (GRCm39) probably benign Het
Atp4a T G 7: 30,424,129 (GRCm39) C968G probably benign Het
Clec4n T C 6: 123,207,474 (GRCm39) C13R possibly damaging Het
Cnot3 T C 7: 3,656,247 (GRCm39) Y178H probably damaging Het
Col18a1 G A 10: 76,891,532 (GRCm39) R1560C probably damaging Het
Dcn A C 10: 97,319,314 (GRCm39) E30D probably damaging Het
Dennd5a A T 7: 109,532,865 (GRCm39) F302I probably damaging Het
Dip2b T C 15: 100,113,088 (GRCm39) V1501A probably damaging Het
Dnah10 C T 5: 124,825,521 (GRCm39) P687S probably damaging Het
Drc7 A G 8: 95,794,755 (GRCm39) T387A probably benign Het
Dusp7 T A 9: 106,251,009 (GRCm39) M378K probably damaging Het
Ftmt T C 18: 52,464,953 (GRCm39) Y90H probably damaging Het
Glb1l3 T C 9: 26,739,659 (GRCm39) probably null Het
Gpatch3 T C 4: 133,305,433 (GRCm39) F223L probably damaging Het
Gpr158 T A 2: 21,787,972 (GRCm39) F538I probably benign Het
Gucy2e A G 11: 69,121,008 (GRCm39) probably benign Het
Hadha A G 5: 30,326,524 (GRCm39) V566A probably benign Het
Hectd4 A T 5: 121,492,021 (GRCm39) S3787C possibly damaging Het
Hnrnpk A T 13: 58,542,130 (GRCm39) D265E possibly damaging Het
Hspbp1 G A 7: 4,687,363 (GRCm39) R83W probably damaging Het
Hspg2 T A 4: 137,243,248 (GRCm39) L758Q probably damaging Het
Ippk A G 13: 49,595,463 (GRCm39) Y180C probably damaging Het
Itpr3 T A 17: 27,330,242 (GRCm39) M1620K probably benign Het
Klf7 T C 1: 64,074,885 (GRCm39) K298R possibly damaging Het
Ktn1 A T 14: 47,970,741 (GRCm39) T1229S probably benign Het
Lefty2 A G 1: 180,725,115 (GRCm39) N282D probably damaging Het
Lrrc37 A T 11: 103,507,242 (GRCm39) probably benign Het
Nsd1 G A 13: 55,394,858 (GRCm39) E820K probably damaging Het
Obsl1 C A 1: 75,469,228 (GRCm39) A1238S probably benign Het
Odr4 G T 1: 150,239,290 (GRCm39) P378T probably benign Het
Pias2 T C 18: 77,220,938 (GRCm39) I391T possibly damaging Het
Ppp1r10 G T 17: 36,241,516 (GRCm39) G764* probably null Het
Ptpra T C 2: 130,359,707 (GRCm39) F158L probably damaging Het
Recql T C 6: 142,323,918 (GRCm39) S59G probably benign Het
Rrp1b A T 17: 32,276,150 (GRCm39) I566F probably benign Het
Sh3yl1 G A 12: 30,991,979 (GRCm39) D145N possibly damaging Het
Slc35f5 T A 1: 125,512,922 (GRCm39) I52N probably damaging Het
Slc51b A G 9: 65,322,447 (GRCm39) probably null Het
Smpd4 C T 16: 17,443,671 (GRCm39) Q72* probably null Het
Spata6 A G 4: 111,679,963 (GRCm39) D391G probably benign Het
Tnc T A 4: 63,885,543 (GRCm39) D1853V possibly damaging Het
Tnks1bp1 C T 2: 84,893,058 (GRCm39) T333I probably benign Het
Vmn2r100 T A 17: 19,752,207 (GRCm39) I813N probably damaging Het
Vwa8 T A 14: 79,246,690 (GRCm39) H677Q probably benign Het
Washc4 T C 10: 83,426,883 (GRCm39) Y1064H probably damaging Het
Wdr82 T A 9: 106,063,614 (GRCm39) I272K probably benign Het
Zc3h12a T C 4: 125,013,097 (GRCm39) Y589C probably damaging Het
Other mutations in Cyp2c66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01145:Cyp2c66 APN 19 39,159,405 (GRCm39) missense probably benign 0.00
IGL01589:Cyp2c66 APN 19 39,172,379 (GRCm39) critical splice donor site probably null
IGL02098:Cyp2c66 APN 19 39,159,473 (GRCm39) missense probably damaging 1.00
IGL02114:Cyp2c66 APN 19 39,159,519 (GRCm39) splice site probably benign
IGL02567:Cyp2c66 APN 19 39,175,084 (GRCm39) utr 3 prime probably benign
IGL03230:Cyp2c66 APN 19 39,172,302 (GRCm39) missense possibly damaging 0.91
R0007:Cyp2c66 UTSW 19 39,159,402 (GRCm39) nonsense probably null
R0092:Cyp2c66 UTSW 19 39,172,224 (GRCm39) splice site probably benign
R0242:Cyp2c66 UTSW 19 39,130,369 (GRCm39) missense probably damaging 1.00
R0242:Cyp2c66 UTSW 19 39,130,369 (GRCm39) missense probably damaging 1.00
R0324:Cyp2c66 UTSW 19 39,165,135 (GRCm39) missense probably benign 0.27
R0675:Cyp2c66 UTSW 19 39,175,060 (GRCm39) missense possibly damaging 0.93
R1127:Cyp2c66 UTSW 19 39,151,812 (GRCm39) missense probably damaging 1.00
R1871:Cyp2c66 UTSW 19 39,151,858 (GRCm39) missense possibly damaging 0.66
R3404:Cyp2c66 UTSW 19 39,151,771 (GRCm39) missense probably benign
R3429:Cyp2c66 UTSW 19 39,151,892 (GRCm39) missense probably damaging 0.97
R3896:Cyp2c66 UTSW 19 39,130,722 (GRCm39) missense possibly damaging 0.82
R4115:Cyp2c66 UTSW 19 39,165,003 (GRCm39) missense possibly damaging 0.66
R4116:Cyp2c66 UTSW 19 39,165,003 (GRCm39) missense possibly damaging 0.66
R4667:Cyp2c66 UTSW 19 39,165,100 (GRCm39) missense probably damaging 1.00
R4668:Cyp2c66 UTSW 19 39,165,100 (GRCm39) missense probably damaging 1.00
R4711:Cyp2c66 UTSW 19 39,151,843 (GRCm39) missense possibly damaging 0.74
R4960:Cyp2c66 UTSW 19 39,151,766 (GRCm39) critical splice acceptor site probably null
R5070:Cyp2c66 UTSW 19 39,151,914 (GRCm39) missense probably benign 0.15
R5113:Cyp2c66 UTSW 19 39,151,882 (GRCm39) missense probably benign 0.00
R5125:Cyp2c66 UTSW 19 39,159,473 (GRCm39) missense probably damaging 1.00
R5178:Cyp2c66 UTSW 19 39,159,473 (GRCm39) missense probably damaging 1.00
R5588:Cyp2c66 UTSW 19 39,151,858 (GRCm39) missense possibly damaging 0.66
R6011:Cyp2c66 UTSW 19 39,130,380 (GRCm39) missense probably benign 0.00
R6497:Cyp2c66 UTSW 19 39,151,821 (GRCm39) missense probably damaging 0.96
R6707:Cyp2c66 UTSW 19 39,174,944 (GRCm39) missense probably damaging 1.00
R7173:Cyp2c66 UTSW 19 39,159,401 (GRCm39) missense probably benign 0.01
R7202:Cyp2c66 UTSW 19 39,130,348 (GRCm39) missense probably damaging 1.00
R7469:Cyp2c66 UTSW 19 39,172,307 (GRCm39) missense probably damaging 1.00
R7614:Cyp2c66 UTSW 19 39,159,472 (GRCm39) missense probably damaging 0.98
R7985:Cyp2c66 UTSW 19 39,102,430 (GRCm39) missense probably null 1.00
R8012:Cyp2c66 UTSW 19 39,172,369 (GRCm39) missense probably damaging 1.00
R8056:Cyp2c66 UTSW 19 39,130,485 (GRCm39) missense probably benign 0.00
R8302:Cyp2c66 UTSW 19 39,165,078 (GRCm39) missense probably damaging 1.00
R8329:Cyp2c66 UTSW 19 39,174,906 (GRCm39) nonsense probably null
R8365:Cyp2c66 UTSW 19 39,165,048 (GRCm39) missense probably benign 0.00
R8472:Cyp2c66 UTSW 19 39,165,021 (GRCm39) missense probably benign 0.03
R8502:Cyp2c66 UTSW 19 39,130,773 (GRCm39) missense probably benign 0.01
R8688:Cyp2c66 UTSW 19 39,151,884 (GRCm39) missense probably benign 0.00
R8715:Cyp2c66 UTSW 19 39,159,388 (GRCm39) missense probably benign 0.01
R9199:Cyp2c66 UTSW 19 39,130,800 (GRCm39) missense probably benign 0.16
R9551:Cyp2c66 UTSW 19 39,172,246 (GRCm39) missense probably damaging 0.99
R9552:Cyp2c66 UTSW 19 39,172,246 (GRCm39) missense probably damaging 0.99
R9601:Cyp2c66 UTSW 19 39,175,054 (GRCm39) missense probably benign
R9777:Cyp2c66 UTSW 19 39,102,520 (GRCm39) missense probably benign 0.15
Z1177:Cyp2c66 UTSW 19 39,175,070 (GRCm39) missense probably damaging 0.96
Posted On 2016-08-02