Incidental Mutation 'IGL03182:Agbl3'
ID 412277
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Agbl3
Ensembl Gene ENSMUSG00000038836
Gene Name ATP/GTP binding protein-like 3
Synonyms 4930431N21Rik, 2900053G10Rik, 6530406M24Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03182
Quality Score
Status
Chromosome 6
Chromosomal Location 34780432-34859459 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 34803500 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Lysine to Asparagine at position 469 (K469N)
Ref Sequence ENSEMBL: ENSMUSP00000110668 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115016] [ENSMUST00000115017] [ENSMUST00000135304] [ENSMUST00000148834]
AlphaFold Q8CDP0
Predicted Effect probably damaging
Transcript: ENSMUST00000115016
AA Change: K469N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110668
Gene: ENSMUSG00000038836
AA Change: K469N

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Pfam:Peptidase_M14 314 563 2.7e-19 PFAM
low complexity region 614 629 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000115017
AA Change: K464N

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000110669
Gene: ENSMUSG00000038836
AA Change: K464N

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Pfam:Peptidase_M14 309 560 1e-33 PFAM
low complexity region 609 624 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000135304
SMART Domains Protein: ENSMUSP00000118303
Gene: ENSMUSG00000038836

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143474
Predicted Effect probably benign
Transcript: ENSMUST00000148834
SMART Domains Protein: ENSMUSP00000116066
Gene: ENSMUSG00000038836

DomainStartEndE-ValueType
low complexity region 2 25 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155726
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155890
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202017
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous mice for a targeted allele are viable and fertile. Mice homozygous for a knock-out allele exhibit normal response to herpes simplex virus (HSV) and vaccinia virus (VACV) infection. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh2 A G 5: 121,580,724 probably benign Het
Ankfy1 T C 11: 72,728,754 probably benign Het
Ankhd1 C T 18: 36,578,774 T209I probably benign Het
Aox3 G A 1: 58,165,887 V754I probably benign Het
Arfgef3 C T 10: 18,600,544 R1509H probably damaging Het
AU019823 T C 9: 50,612,398 N50S possibly damaging Het
Ccdc157 A G 11: 4,151,832 S30P probably damaging Het
Cept1 T A 3: 106,504,550 E369D probably damaging Het
Clcnka T C 4: 141,394,487 Y236C probably damaging Het
Ddx42 A T 11: 106,247,527 L717F probably benign Het
Dnah11 A T 12: 118,030,291 I2340N probably damaging Het
Dsel T C 1: 111,860,138 E889G probably damaging Het
Fasn T C 11: 120,812,726 Y1560C probably damaging Het
Fermt2 A T 14: 45,461,768 M623K possibly damaging Het
Gm21970 T A 16: 91,393,838 S110T possibly damaging Het
Gm826 T A 2: 160,327,115 R91S unknown Het
Lrrn3 A G 12: 41,454,021 L99S probably damaging Het
Megf8 T A 7: 25,347,348 M1552K possibly damaging Het
Mgll G T 6: 88,823,191 V191F probably damaging Het
Nol8 C A 13: 49,664,081 H778N probably damaging Het
Olfr1090 A T 2: 86,754,022 S239T probably damaging Het
Olfr1471 A C 19: 13,445,443 T144P possibly damaging Het
Olfr385 T A 11: 73,589,442 T99S probably benign Het
Olfr948 A T 9: 39,318,981 M211K probably benign Het
Pfkfb3 A T 2: 11,501,663 I13N probably damaging Het
Pim1 T A 17: 29,491,766 D114E possibly damaging Het
Pkd1 T C 17: 24,573,818 L1493P probably damaging Het
Plb1 A T 5: 32,344,915 probably benign Het
Plch1 A T 3: 63,702,594 Y872* probably null Het
Rictor A G 15: 6,789,598 D1434G probably benign Het
Rptor G A 11: 119,725,145 G162R probably damaging Het
Serping1 T C 2: 84,765,818 D424G probably damaging Het
Slit2 A G 5: 48,220,053 I475V possibly damaging Het
Snx31 G T 15: 36,525,687 Q289K probably benign Het
Tbc1d13 G A 2: 30,147,367 A254T probably damaging Het
Tek T C 4: 94,851,765 I750T probably damaging Het
Tet2 A T 3: 133,471,398 L1296* probably null Het
Tmem145 T A 7: 25,314,879 F459I probably damaging Het
Uba5 A T 9: 104,054,129 V247D possibly damaging Het
Vmn1r83 T C 7: 12,321,690 M147V probably benign Het
Vwde T C 6: 13,187,139 D783G probably damaging Het
Zfp609 A G 9: 65,701,005 S1198P probably benign Het
Other mutations in Agbl3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Agbl3 APN 6 34,846,836 (GRCm38) missense probably damaging 1.00
IGL00835:Agbl3 APN 6 34,799,732 (GRCm38) missense probably damaging 1.00
IGL00840:Agbl3 APN 6 34,799,159 (GRCm38) missense possibly damaging 0.95
IGL01090:Agbl3 APN 6 34,799,887 (GRCm38) missense probably benign 0.40
IGL01123:Agbl3 APN 6 34,846,976 (GRCm38) nonsense probably null
IGL01707:Agbl3 APN 6 34,839,454 (GRCm38) missense possibly damaging 0.78
IGL01728:Agbl3 APN 6 34,782,157 (GRCm38) start codon destroyed probably null
IGL02335:Agbl3 APN 6 34,799,750 (GRCm38) missense probably damaging 1.00
IGL02420:Agbl3 APN 6 34,785,307 (GRCm38) missense possibly damaging 0.47
IGL02551:Agbl3 APN 6 34,823,071 (GRCm38) missense possibly damaging 0.88
IGL02974:Agbl3 APN 6 34,799,822 (GRCm38) missense probably damaging 1.00
IGL03167:Agbl3 APN 6 34,857,659 (GRCm38) missense possibly damaging 0.92
R0044:Agbl3 UTSW 6 34,799,899 (GRCm38) missense probably damaging 1.00
R0499:Agbl3 UTSW 6 34,839,335 (GRCm38) missense probably benign
R0639:Agbl3 UTSW 6 34,799,705 (GRCm38) missense probably damaging 1.00
R0850:Agbl3 UTSW 6 34,799,204 (GRCm38) missense probably damaging 1.00
R1004:Agbl3 UTSW 6 34,803,451 (GRCm38) missense probably damaging 0.99
R1080:Agbl3 UTSW 6 34,828,235 (GRCm38) missense probably benign 0.14
R1589:Agbl3 UTSW 6 34,857,517 (GRCm38) missense possibly damaging 0.77
R2361:Agbl3 UTSW 6 34,832,505 (GRCm38) missense possibly damaging 0.87
R2495:Agbl3 UTSW 6 34,846,764 (GRCm38) missense probably damaging 1.00
R3236:Agbl3 UTSW 6 34,823,087 (GRCm38) splice site probably null
R3237:Agbl3 UTSW 6 34,823,087 (GRCm38) splice site probably null
R3420:Agbl3 UTSW 6 34,793,965 (GRCm38) missense probably benign 0.36
R3421:Agbl3 UTSW 6 34,793,965 (GRCm38) missense probably benign 0.36
R3422:Agbl3 UTSW 6 34,793,965 (GRCm38) missense probably benign 0.36
R3810:Agbl3 UTSW 6 34,799,729 (GRCm38) missense probably damaging 1.00
R3811:Agbl3 UTSW 6 34,799,729 (GRCm38) missense probably damaging 1.00
R4059:Agbl3 UTSW 6 34,846,899 (GRCm38) missense probably damaging 1.00
R4499:Agbl3 UTSW 6 34,857,598 (GRCm38) missense probably benign 0.00
R4687:Agbl3 UTSW 6 34,798,326 (GRCm38) missense probably damaging 1.00
R4854:Agbl3 UTSW 6 34,785,284 (GRCm38) missense probably damaging 0.97
R5354:Agbl3 UTSW 6 34,814,752 (GRCm38) missense probably benign 0.03
R5386:Agbl3 UTSW 6 34,799,196 (GRCm38) missense probably damaging 1.00
R5897:Agbl3 UTSW 6 34,803,573 (GRCm38) missense probably benign 0.21
R6018:Agbl3 UTSW 6 34,799,255 (GRCm38) missense probably damaging 1.00
R6148:Agbl3 UTSW 6 34,857,753 (GRCm38) missense possibly damaging 0.87
R6305:Agbl3 UTSW 6 34,782,210 (GRCm38) missense unknown
R6525:Agbl3 UTSW 6 34,803,594 (GRCm38) nonsense probably null
R6546:Agbl3 UTSW 6 34,799,299 (GRCm38) missense probably damaging 1.00
R6743:Agbl3 UTSW 6 34,846,953 (GRCm38) missense probably benign 0.03
R6986:Agbl3 UTSW 6 34,839,452 (GRCm38) missense probably benign 0.42
R7023:Agbl3 UTSW 6 34,814,769 (GRCm38) missense probably benign 0.02
R7411:Agbl3 UTSW 6 34,814,819 (GRCm38) missense probably damaging 0.99
R7469:Agbl3 UTSW 6 34,814,414 (GRCm38) missense probably damaging 1.00
R7631:Agbl3 UTSW 6 34,857,671 (GRCm38) missense possibly damaging 0.95
R7658:Agbl3 UTSW 6 34,832,508 (GRCm38) missense probably benign 0.11
R7743:Agbl3 UTSW 6 34,846,830 (GRCm38) missense probably damaging 1.00
R7801:Agbl3 UTSW 6 34,839,365 (GRCm38) missense probably benign 0.00
R8033:Agbl3 UTSW 6 34,839,494 (GRCm38) missense possibly damaging 0.95
R8203:Agbl3 UTSW 6 34,799,479 (GRCm38) missense probably damaging 1.00
R8769:Agbl3 UTSW 6 34,857,614 (GRCm38) missense probably damaging 0.96
R9072:Agbl3 UTSW 6 34,799,452 (GRCm38) missense probably damaging 1.00
R9073:Agbl3 UTSW 6 34,799,452 (GRCm38) missense probably damaging 1.00
R9210:Agbl3 UTSW 6 34,798,242 (GRCm38) missense probably damaging 0.98
R9255:Agbl3 UTSW 6 34,812,905 (GRCm38) missense probably damaging 1.00
R9536:Agbl3 UTSW 6 34,846,926 (GRCm38) missense probably benign
R9560:Agbl3 UTSW 6 34,846,908 (GRCm38) missense possibly damaging 0.94
R9662:Agbl3 UTSW 6 34,832,533 (GRCm38) nonsense probably null
RF014:Agbl3 UTSW 6 34,799,358 (GRCm38) missense possibly damaging 0.53
Z1177:Agbl3 UTSW 6 34,799,408 (GRCm38) missense probably damaging 1.00
Posted On 2016-08-02