Incidental Mutation 'IGL03182:Zfp609'
| ID |
412302 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp609
|
| Ensembl Gene |
ENSMUSG00000040524 |
| Gene Name |
zinc finger protein 609 |
| Synonyms |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.620)
|
| Stock # |
IGL03182
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
65599673-65734846 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 65608287 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1198
(S1198P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124089
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159109]
|
| AlphaFold |
Q8BZ47 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159109
AA Change: S1198P
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000124089
Gene: ENSMUSG00000040524
AA Change: S1198P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
101 |
N/A |
INTRINSIC |
|
low complexity region
|
125 |
139 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
176 |
N/A |
INTRINSIC |
|
low complexity region
|
259 |
269 |
N/A |
INTRINSIC |
|
low complexity region
|
365 |
376 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
405 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
495 |
520 |
2.14e0 |
SMART |
|
low complexity region
|
629 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
657 |
667 |
N/A |
INTRINSIC |
|
low complexity region
|
724 |
738 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1020 |
N/A |
INTRINSIC |
|
low complexity region
|
1210 |
1219 |
N/A |
INTRINSIC |
|
low complexity region
|
1257 |
1273 |
N/A |
INTRINSIC |
|
low complexity region
|
1329 |
1348 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159878
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 42 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Agbl3 |
A |
T |
6: 34,780,435 (GRCm39) |
K469N |
probably damaging |
Het |
| Aldh2 |
A |
G |
5: 121,718,787 (GRCm39) |
|
probably benign |
Het |
| Ankfy1 |
T |
C |
11: 72,619,580 (GRCm39) |
|
probably benign |
Het |
| Ankhd1 |
C |
T |
18: 36,711,827 (GRCm39) |
T209I |
probably benign |
Het |
| Aox3 |
G |
A |
1: 58,205,046 (GRCm39) |
V754I |
probably benign |
Het |
| Arfgef3 |
C |
T |
10: 18,476,292 (GRCm39) |
R1509H |
probably damaging |
Het |
| Ccdc157 |
A |
G |
11: 4,101,832 (GRCm39) |
S30P |
probably damaging |
Het |
| Cept1 |
T |
A |
3: 106,411,866 (GRCm39) |
E369D |
probably damaging |
Het |
| Clcnka |
T |
C |
4: 141,121,798 (GRCm39) |
Y236C |
probably damaging |
Het |
| Ddx42 |
A |
T |
11: 106,138,353 (GRCm39) |
L717F |
probably benign |
Het |
| Dnah11 |
A |
T |
12: 117,994,026 (GRCm39) |
I2340N |
probably damaging |
Het |
| Dsel |
T |
C |
1: 111,787,868 (GRCm39) |
E889G |
probably damaging |
Het |
| Fasn |
T |
C |
11: 120,703,552 (GRCm39) |
Y1560C |
probably damaging |
Het |
| Fermt2 |
A |
T |
14: 45,699,225 (GRCm39) |
M623K |
possibly damaging |
Het |
| Gm21970 |
T |
A |
16: 91,190,726 (GRCm39) |
S110T |
possibly damaging |
Het |
| Gm826 |
T |
A |
2: 160,169,035 (GRCm39) |
R91S |
unknown |
Het |
| Lrrn3 |
A |
G |
12: 41,504,020 (GRCm39) |
L99S |
probably damaging |
Het |
| Megf8 |
T |
A |
7: 25,046,773 (GRCm39) |
M1552K |
possibly damaging |
Het |
| Mgll |
G |
T |
6: 88,800,173 (GRCm39) |
V191F |
probably damaging |
Het |
| Nkapd1 |
T |
C |
9: 50,523,698 (GRCm39) |
N50S |
possibly damaging |
Het |
| Nol8 |
C |
A |
13: 49,817,557 (GRCm39) |
H778N |
probably damaging |
Het |
| Or1e26 |
T |
A |
11: 73,480,268 (GRCm39) |
T99S |
probably benign |
Het |
| Or5b116 |
A |
C |
19: 13,422,807 (GRCm39) |
T144P |
possibly damaging |
Het |
| Or8g30 |
A |
T |
9: 39,230,277 (GRCm39) |
M211K |
probably benign |
Het |
| Or8k40 |
A |
T |
2: 86,584,366 (GRCm39) |
S239T |
probably damaging |
Het |
| Pfkfb3 |
A |
T |
2: 11,506,474 (GRCm39) |
I13N |
probably damaging |
Het |
| Pim1 |
T |
A |
17: 29,710,740 (GRCm39) |
D114E |
possibly damaging |
Het |
| Pkd1 |
T |
C |
17: 24,792,792 (GRCm39) |
L1493P |
probably damaging |
Het |
| Plb1 |
A |
T |
5: 32,502,259 (GRCm39) |
|
probably benign |
Het |
| Plch1 |
A |
T |
3: 63,610,015 (GRCm39) |
Y872* |
probably null |
Het |
| Rictor |
A |
G |
15: 6,819,079 (GRCm39) |
D1434G |
probably benign |
Het |
| Rptor |
G |
A |
11: 119,615,971 (GRCm39) |
G162R |
probably damaging |
Het |
| Serping1 |
T |
C |
2: 84,596,162 (GRCm39) |
D424G |
probably damaging |
Het |
| Slit2 |
A |
G |
5: 48,377,395 (GRCm39) |
I475V |
possibly damaging |
Het |
| Snx31 |
G |
T |
15: 36,525,833 (GRCm39) |
Q289K |
probably benign |
Het |
| Tbc1d13 |
G |
A |
2: 30,037,379 (GRCm39) |
A254T |
probably damaging |
Het |
| Tek |
T |
C |
4: 94,740,002 (GRCm39) |
I750T |
probably damaging |
Het |
| Tet2 |
A |
T |
3: 133,177,159 (GRCm39) |
L1296* |
probably null |
Het |
| Tmem145 |
T |
A |
7: 25,014,304 (GRCm39) |
F459I |
probably damaging |
Het |
| Uba5 |
A |
T |
9: 103,931,328 (GRCm39) |
V247D |
possibly damaging |
Het |
| Vmn1r83 |
T |
C |
7: 12,055,617 (GRCm39) |
M147V |
probably benign |
Het |
| Vwde |
T |
C |
6: 13,187,138 (GRCm39) |
D783G |
probably damaging |
Het |
|
| Other mutations in Zfp609 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00956:Zfp609
|
APN |
9 |
65,610,045 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL01688:Zfp609
|
APN |
9 |
65,611,307 (GRCm39) |
missense |
probably benign |
|
|
IGL01718:Zfp609
|
APN |
9 |
65,609,682 (GRCm39) |
nonsense |
probably null |
|
|
IGL01860:Zfp609
|
APN |
9 |
65,610,116 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL02441:Zfp609
|
APN |
9 |
65,610,611 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02490:Zfp609
|
APN |
9 |
65,611,250 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02614:Zfp609
|
APN |
9 |
65,610,072 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02794:Zfp609
|
APN |
9 |
65,611,602 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL02959:Zfp609
|
APN |
9 |
65,610,675 (GRCm39) |
missense |
probably benign |
|
|
IGL02967:Zfp609
|
APN |
9 |
65,604,901 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
IGL03036:Zfp609
|
APN |
9 |
65,609,927 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
H8441:Zfp609
|
UTSW |
9 |
65,702,169 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0304:Zfp609
|
UTSW |
9 |
65,608,470 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0487:Zfp609
|
UTSW |
9 |
65,609,916 (GRCm39) |
missense |
unknown |
|
|
R0505:Zfp609
|
UTSW |
9 |
65,610,744 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0684:Zfp609
|
UTSW |
9 |
65,638,483 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1480:Zfp609
|
UTSW |
9 |
65,610,593 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1507:Zfp609
|
UTSW |
9 |
65,702,059 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1579:Zfp609
|
UTSW |
9 |
65,611,754 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1655:Zfp609
|
UTSW |
9 |
65,610,836 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1692:Zfp609
|
UTSW |
9 |
65,702,593 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1701:Zfp609
|
UTSW |
9 |
65,638,282 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1735:Zfp609
|
UTSW |
9 |
65,610,374 (GRCm39) |
nonsense |
probably null |
|
|
R1883:Zfp609
|
UTSW |
9 |
65,702,040 (GRCm39) |
missense |
probably benign |
|
|
R1970:Zfp609
|
UTSW |
9 |
65,702,559 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2059:Zfp609
|
UTSW |
9 |
65,611,716 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2302:Zfp609
|
UTSW |
9 |
65,702,179 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3404:Zfp609
|
UTSW |
9 |
65,608,454 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R3405:Zfp609
|
UTSW |
9 |
65,608,454 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R4514:Zfp609
|
UTSW |
9 |
65,610,977 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4533:Zfp609
|
UTSW |
9 |
65,610,890 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5043:Zfp609
|
UTSW |
9 |
65,608,109 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5499:Zfp609
|
UTSW |
9 |
65,610,137 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7081:Zfp609
|
UTSW |
9 |
65,609,723 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7514:Zfp609
|
UTSW |
9 |
65,613,418 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7677:Zfp609
|
UTSW |
9 |
65,604,456 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7684:Zfp609
|
UTSW |
9 |
65,638,362 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8229:Zfp609
|
UTSW |
9 |
65,610,782 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8266:Zfp609
|
UTSW |
9 |
65,610,996 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8278:Zfp609
|
UTSW |
9 |
65,604,804 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8934:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8938:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8940:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8986:Zfp609
|
UTSW |
9 |
65,610,561 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9267:Zfp609
|
UTSW |
9 |
65,608,328 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9456:Zfp609
|
UTSW |
9 |
65,611,125 (GRCm39) |
missense |
|
|
|
R9561:Zfp609
|
UTSW |
9 |
65,604,512 (GRCm39) |
nonsense |
probably null |
|
|
X0028:Zfp609
|
UTSW |
9 |
65,604,362 (GRCm39) |
small deletion |
probably benign |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation