Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03185:Zfp446'

412448

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp446

Ensembl Gene

ENSMUSG00000033961

Gene Name

zinc finger protein 446

Synonyms

A630035I11Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL03185

Quality Score

Status

Chromosome

Chromosomal Location

12711726-12718323 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 12712925 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 88 (V88F)

Ref Sequence

ENSEMBL: ENSMUSP00000039073 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000045810] [ENSMUST00000108535] [ENSMUST00000108536] [ENSMUST00000108537] [ENSMUST00000124387]

AlphaFold

Q8C9M8

Predicted Effect

probably null
Transcript: ENSMUST00000045810
AA Change: V88F

PolyPhen 2 Score 0.430 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000039073
Gene: ENSMUSG00000033961
AA Change: V88F

Domain	Start	End	E-Value	Type
low complexity region	67	79	N/A	INTRINSIC
SCAN	122	234	1.29e-53	SMART
KRAB	299	360	3.96e-2	SMART
ZnF_C2H2	419	441	2.95e-3	SMART
ZnF_C2H2	468	490	8.47e-4	SMART
ZnF_C2H2	496	518	5.34e-1	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000108535

SMART Domains

Protein: ENSMUSP00000104175
Gene: ENSMUSG00000033961

Domain	Start	End	E-Value	Type
SCAN	22	134	1.29e-53	SMART
KRAB	199	254	1.14e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000108536

SMART Domains

Protein: ENSMUSP00000104176
Gene: ENSMUSG00000033961

Domain	Start	End	E-Value	Type
SCAN	22	134	1.29e-53	SMART
KRAB	199	260	3.96e-2	SMART
ZnF_C2H2	319	341	2.95e-3	SMART
ZnF_C2H2	368	390	8.47e-4	SMART
ZnF_C2H2	396	418	5.34e-1	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000108537

SMART Domains

Protein: ENSMUSP00000104177
Gene: ENSMUSG00000033961

Domain	Start	End	E-Value	Type
SCAN	22	128	7.37e-49	SMART
KRAB	124	185	3.96e-2	SMART
ZnF_C2H2	244	266	2.95e-3	SMART
ZnF_C2H2	293	315	8.47e-4	SMART
ZnF_C2H2	321	343	5.34e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000124387

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000128427

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000147996

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam15	T	C	3: 89,255,212 (GRCm39)	D77G	probably benign	Het
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Babam2	T	C	5: 31,859,376 (GRCm39)	I27T	possibly damaging	Het
Ccdc150	A	G	1: 54,339,482 (GRCm39)	E442G	probably damaging	Het
Ccdc92	A	G	5: 124,913,014 (GRCm39)	Y172H	probably damaging	Het
Chl1	T	A	6: 103,642,824 (GRCm39)	D187E	probably damaging	Het
Col6a4	A	T	9: 105,896,653 (GRCm39)	F1721I	probably damaging	Het
Corin	C	T	5: 72,490,124 (GRCm39)	G542D	probably damaging	Het
Dennd1c	C	T	17: 57,373,803 (GRCm39)	D587N	probably benign	Het
Dnah10	A	G	5: 124,894,707 (GRCm39)	Y3424C	probably damaging	Het
Echdc1	T	A	10: 29,207,836 (GRCm39)	F127I	possibly damaging	Het
F13b	T	A	1: 139,444,124 (GRCm39)	V486E	probably benign	Het
Fkbp15	C	T	4: 62,250,423 (GRCm39)		probably null	Het
Glt8d2	T	A	10: 82,498,110 (GRCm39)	I100F	probably damaging	Het
Gmip	C	T	8: 70,262,433 (GRCm39)	P10L	probably benign	Het
Grm7	T	C	6: 110,623,183 (GRCm39)	S119P	possibly damaging	Het
Klf4	T	C	4: 55,530,911 (GRCm39)	T58A	possibly damaging	Het
Mink1	T	C	11: 70,494,686 (GRCm39)	I289T	probably damaging	Het
Mptx2	A	T	1: 173,102,356 (GRCm39)	V111D	possibly damaging	Het
Muc5b	A	T	7: 141,416,559 (GRCm39)	E3168D	possibly damaging	Het
Mylk3	C	A	8: 86,053,833 (GRCm39)	V695F	probably damaging	Het
Or11j4	C	A	14: 50,630,855 (GRCm39)	T214K	probably damaging	Het
Or7g21	T	A	9: 19,033,034 (GRCm39)	V258E	probably damaging	Het
Pcare	A	T	17: 72,056,332 (GRCm39)	I1115K	probably damaging	Het
Pira13	A	G	7: 3,826,229 (GRCm39)	Y255H	probably damaging	Het
Poglut2	G	A	1: 44,156,359 (GRCm39)	S76L	probably benign	Het
Pprc1	C	A	19: 46,058,186 (GRCm39)		probably benign	Het
Prkaa2	C	T	4: 104,896,918 (GRCm39)		probably null	Het
Prss50	A	G	9: 110,687,279 (GRCm39)	Y74C	probably benign	Het
Rnf145	T	C	11: 44,422,157 (GRCm39)	L80P	probably damaging	Het
Serpinb3b	T	C	1: 107,084,662 (GRCm39)	I120V	probably benign	Het
Sgca	T	C	11: 94,861,610 (GRCm39)	M212V	probably benign	Het
Slc1a6	T	A	10: 78,637,741 (GRCm39)	D422E	probably damaging	Het
Slc30a9	A	G	5: 67,490,406 (GRCm39)	R226G	probably benign	Het
Slc5a11	A	G	7: 122,864,412 (GRCm39)	D336G	possibly damaging	Het
Slfn8	T	C	11: 82,908,333 (GRCm39)	H70R	probably benign	Het
Stoml2	T	C	4: 43,029,065 (GRCm39)	N269S	probably benign	Het
Synrg	A	G	11: 83,872,305 (GRCm39)	E142G	probably damaging	Het
Thbs2	G	A	17: 14,901,672 (GRCm39)	Q436*	probably null	Het
Tyk2	T	C	9: 21,020,680 (GRCm39)	N917S	probably damaging	Het
Zfhx4	C	A	3: 5,468,974 (GRCm39)	T3069K	probably benign	Het
Zp3	A	G	5: 136,011,575 (GRCm39)	N131S	possibly damaging	Het

Other mutations in Zfp446

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01486:Zfp446	APN	7	12,713,307 (GRCm39)	critical splice donor site	probably null
IGL01534:Zfp446	APN	7	12,713,493 (GRCm39)	missense	probably damaging	1.00
IGL02471:Zfp446	APN	7	12,716,181 (GRCm39)	missense	probably benign	0.41
IGL02888:Zfp446	APN	7	12,713,255 (GRCm39)	missense	probably damaging	1.00
IGL03153:Zfp446	APN	7	12,711,834 (GRCm39)	missense	probably benign	0.01
IGL03242:Zfp446	APN	7	12,713,252 (GRCm39)	missense	probably damaging	1.00
R0538:Zfp446	UTSW	7	12,713,516 (GRCm39)	missense	possibly damaging	0.94
R1809:Zfp446	UTSW	7	12,713,048 (GRCm39)	missense	probably damaging	1.00
R3686:Zfp446	UTSW	7	12,716,580 (GRCm39)	missense	probably damaging	0.97
R3701:Zfp446	UTSW	7	12,712,079 (GRCm39)	unclassified	probably benign
R5256:Zfp446	UTSW	7	12,713,231 (GRCm39)	nonsense	probably null
R5363:Zfp446	UTSW	7	12,711,984 (GRCm39)	missense	probably benign	0.20
R5377:Zfp446	UTSW	7	12,716,178 (GRCm39)	missense	possibly damaging	0.88
R6806:Zfp446	UTSW	7	12,713,043 (GRCm39)	missense	probably damaging	1.00
R7167:Zfp446	UTSW	7	12,712,049 (GRCm39)	unclassified	probably benign
R7988:Zfp446	UTSW	7	12,712,970 (GRCm39)	missense	possibly damaging	0.93
R8288:Zfp446	UTSW	7	12,711,885 (GRCm39)	missense	probably benign	0.00
R8487:Zfp446	UTSW	7	12,716,555 (GRCm39)	missense	possibly damaging	0.68
R8943:Zfp446	UTSW	7	12,713,564 (GRCm39)	nonsense	probably null
R9315:Zfp446	UTSW	7	12,713,397 (GRCm39)	missense	probably benign	0.28
Z1177:Zfp446	UTSW	7	12,712,093 (GRCm39)	unclassified	probably benign

Posted On

2016-08-02