Incidental Mutation 'IGL03186:Olfr202'
ID412462
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr202
Ensembl Gene ENSMUSG00000048810
Gene Nameolfactory receptor 202
SynonymsMOR182-1, GA_x54KRFPKG5P-55498766-55497843
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #IGL03186
Quality Score
Status
Chromosome16
Chromosomal Location59283516-59286793 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 59283903 bp
ZygosityHeterozygous
Amino Acid Change Valine to Glutamic Acid at position 198 (V198E)
Ref Sequence ENSEMBL: ENSMUSP00000151058 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049859] [ENSMUST00000201687] [ENSMUST00000217485]
Predicted Effect probably damaging
Transcript: ENSMUST00000049859
AA Change: V198E

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000059496
Gene: ENSMUSG00000048810
AA Change: V198E

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.9e-47 PFAM
Pfam:7TM_GPCR_Srsx 35 296 1.9e-6 PFAM
Pfam:7tm_1 41 290 1.2e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000201687
AA Change: V198E

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000144622
Gene: ENSMUSG00000048810
AA Change: V198E

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 3.4e-46 PFAM
Pfam:7tm_1 40 289 1.4e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217485
AA Change: V198E

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,433,618 I4769T possibly damaging Het
Ankrd53 T C 6: 83,763,713 I106T probably benign Het
Arsi A G 18: 60,917,473 D476G probably damaging Het
Atp2c1 T C 9: 105,413,130 K760E probably benign Het
C030048H21Rik A G 2: 26,253,338 probably null Het
Cep152 A G 2: 125,563,975 S1546P probably benign Het
Clock T C 5: 76,243,082 H291R probably damaging Het
Fkbp4 T C 6: 128,434,800 T109A probably benign Het
Igkv1-117 T C 6: 68,121,799 Y111H probably damaging Het
Kif20b A T 19: 34,934,944 E250V probably benign Het
Mef2c A G 13: 83,652,868 N229S probably benign Het
Ndufa9 A G 6: 126,844,892 V36A possibly damaging Het
Neb T C 2: 52,210,659 probably benign Het
Neb G A 2: 52,169,088 H213Y probably damaging Het
Neurl1a T A 19: 47,240,477 F152Y probably damaging Het
Nlrp14 G T 7: 107,186,670 C651F probably damaging Het
Odf3l1 T G 9: 56,849,072 N220T probably benign Het
Olfr1239 T A 2: 89,417,844 T190S probably damaging Het
Olfr836 T A 9: 19,121,904 D316E probably benign Het
Pex2 C A 3: 5,561,717 A11S probably benign Het
Pitpna C A 11: 75,612,250 H137N probably benign Het
Pole T G 5: 110,299,920 probably null Het
Rft1 T A 14: 30,658,349 I35N possibly damaging Het
Serpina1e T C 12: 103,949,203 H248R probably benign Het
Sgsm1 C T 5: 113,285,021 A254T probably benign Het
St3gal3 G A 4: 117,940,054 P331S possibly damaging Het
Ttn T A 2: 76,771,762 K16773* probably null Het
Zfp687 T C 3: 95,011,094 T456A probably benign Het
Zranb1 A G 7: 132,950,203 I220M possibly damaging Het
Other mutations in Olfr202
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02271:Olfr202 APN 16 59284221 missense probably damaging 0.99
IGL02439:Olfr202 APN 16 59284455 missense probably damaging 1.00
IGL02798:Olfr202 APN 16 59284115 nonsense probably null
IGL03075:Olfr202 APN 16 59283928 missense possibly damaging 0.87
R0270:Olfr202 UTSW 16 59283753 missense probably damaging 1.00
R0631:Olfr202 UTSW 16 59284207 missense possibly damaging 0.60
R1441:Olfr202 UTSW 16 59283865 missense probably benign 0.00
R1546:Olfr202 UTSW 16 59284003 missense probably damaging 1.00
R3403:Olfr202 UTSW 16 59284112 missense probably benign 0.09
R4790:Olfr202 UTSW 16 59284458 missense probably damaging 0.99
R4960:Olfr202 UTSW 16 59283985 missense probably benign 0.23
R5369:Olfr202 UTSW 16 59284380 missense probably damaging 0.97
R5419:Olfr202 UTSW 16 59284341 missense probably damaging 0.99
R5646:Olfr202 UTSW 16 59283979 missense probably benign 0.00
R6048:Olfr202 UTSW 16 59283979 missense probably benign 0.00
R6732:Olfr202 UTSW 16 59283951 missense probably benign 0.16
R6994:Olfr202 UTSW 16 59284090 missense possibly damaging 0.87
R7265:Olfr202 UTSW 16 59283924 missense probably damaging 1.00
R8074:Olfr202 UTSW 16 59284186 missense probably benign 0.22
Z1177:Olfr202 UTSW 16 59283708 missense possibly damaging 0.56
Z1177:Olfr202 UTSW 16 59283930 missense probably damaging 1.00
Posted On2016-08-02