Incidental Mutation 'IGL03187:Krt6b'
ID 412496
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Krt6b
Ensembl Gene ENSMUSG00000023041
Gene Name keratin 6B
Synonyms Krt2-6b, mK6[b]
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.147) question?
Stock # IGL03187
Quality Score
Status
Chromosome 15
Chromosomal Location 101676023-101680287 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 101679957 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 89 (F89L)
Ref Sequence ENSEMBL: ENSMUSP00000023786 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023786]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000023786
AA Change: F89L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000023786
Gene: ENSMUSG00000023041
AA Change: F89L

DomainStartEndE-ValueType
Pfam:Keratin_2_head 15 148 1.3e-36 PFAM
Filament 151 464 2.79e-175 SMART
low complexity region 483 537 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198940
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bbx G A 16: 50,274,563 T130I probably damaging Het
Cdkl2 A G 5: 92,017,380 probably null Het
Clrn1 A G 3: 58,846,433 V169A probably damaging Het
Erbb3 A G 10: 128,572,594 probably benign Het
Gucy2g A C 19: 55,231,052 I379M possibly damaging Het
Hps5 A T 7: 46,773,207 L533Q probably damaging Het
Kansl1l T A 1: 66,725,903 K749N probably damaging Het
Myh1 T C 11: 67,206,525 F439L possibly damaging Het
Neb G A 2: 52,169,088 H213Y probably damaging Het
Nhej1 A G 1: 74,968,261 S111P possibly damaging Het
Olfr728 G T 14: 50,139,800 P280T probably damaging Het
Pcdh15 G A 10: 74,355,874 V601M probably damaging Het
Ripor3 A G 2: 167,985,668 V621A possibly damaging Het
Smarca2 A G 19: 26,672,824 N732S probably damaging Het
Stx18 G A 5: 38,126,983 E170K possibly damaging Het
Syde1 A T 10: 78,589,109 I356N possibly damaging Het
Tex2 C T 11: 106,568,077 probably benign Het
Vmn2r50 T G 7: 10,037,441 T778P probably damaging Het
Zfp709 T G 8: 71,889,282 I184S probably benign Het
Other mutations in Krt6b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00327:Krt6b APN 15 101679832 missense probably benign 0.22
IGL01653:Krt6b APN 15 101679114 missense probably damaging 1.00
IGL01900:Krt6b APN 15 101677546 missense possibly damaging 0.45
R0511:Krt6b UTSW 15 101677607 splice site probably benign
R0788:Krt6b UTSW 15 101677519 missense probably damaging 0.96
R1370:Krt6b UTSW 15 101677552 missense probably damaging 0.96
R1481:Krt6b UTSW 15 101678374 missense probably benign 0.05
R2007:Krt6b UTSW 15 101678127 missense probably damaging 1.00
R2112:Krt6b UTSW 15 101678564 missense possibly damaging 0.48
R2166:Krt6b UTSW 15 101678615 critical splice acceptor site probably null
R2227:Krt6b UTSW 15 101679122 missense probably damaging 0.96
R2495:Krt6b UTSW 15 101678322 missense probably damaging 1.00
R2496:Krt6b UTSW 15 101679781 missense probably damaging 1.00
R4726:Krt6b UTSW 15 101678085 missense probably damaging 0.98
R4969:Krt6b UTSW 15 101680025 missense possibly damaging 0.71
R6301:Krt6b UTSW 15 101678951 missense probably damaging 1.00
R6646:Krt6b UTSW 15 101677214 missense probably damaging 0.98
R7232:Krt6b UTSW 15 101678142 missense probably damaging 1.00
R7406:Krt6b UTSW 15 101679078 missense probably benign 0.04
R7414:Krt6b UTSW 15 101679014 missense probably benign 0.05
R7849:Krt6b UTSW 15 101678574 missense probably damaging 1.00
R8110:Krt6b UTSW 15 101680142 missense probably damaging 0.96
R8348:Krt6b UTSW 15 101678020 missense probably damaging 1.00
R8448:Krt6b UTSW 15 101678020 missense probably damaging 1.00
R8736:Krt6b UTSW 15 101678612 missense probably damaging 1.00
Z1177:Krt6b UTSW 15 101678332 missense probably damaging 1.00
Posted On 2016-08-02