Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03188:Olfr644'

412512

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr644

Ensembl Gene

ENSMUSG00000110012

Gene Name

olfactory receptor 644

Synonyms

GA_x6K02T2PBJ9-6803062-6802118, MOR13-1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.189) question?

Stock #

IGL03188

Quality Score

Status

Chromosome

Chromosomal Location

104066289-104071869 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 104068738 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 98 (S98P)

Ref Sequence

ENSEMBL: ENSMUSP00000149600 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077417] [ENSMUST00000138055] [ENSMUST00000213184] [ENSMUST00000213991]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000077417
AA Change: S98P

PolyPhen 2 Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000076633
Gene: ENSMUSG00000110012
AA Change: S98P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	312	2e-122	PFAM
Pfam:7TM_GPCR_Srsx	37	256	5.9e-8	PFAM
Pfam:7tm_1	43	294	1.4e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000138055

SMART Domains

Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

Domain	Start	End	E-Value	Type
transmembrane domain	29	51	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213184
AA Change: S98P

PolyPhen 2 Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)

Predicted Effect

possibly damaging
Transcript: ENSMUST00000213991
AA Change: S98P

PolyPhen 2 Score 0.891 (Sensitivity: 0.82; Specificity: 0.94)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700022I11Rik	A	G	4: 42,971,225	Y186C	possibly damaging	Het
Adamts18	C	A	8: 113,699,024	C1202F	probably damaging	Het
Ago2	C	T	15: 73,123,333	V466I	probably benign	Het
Ank2	C	A	3: 126,955,870	E503D	probably damaging	Het
Aptx	A	T	4: 40,695,143		probably null	Het
Aurka	A	T	2: 172,363,768	D123E	possibly damaging	Het
AW549877	A	G	15: 3,988,705	Y163H	probably damaging	Het
Btaf1	T	C	19: 36,949,108	I60T	possibly damaging	Het
Ccdc154	A	T	17: 25,164,093		probably null	Het
Cct5	T	C	15: 31,598,002	N55S	probably benign	Het
Cntnap3	A	G	13: 64,781,745	S547P	probably damaging	Het
Efl1	T	A	7: 82,671,701	I114N	probably damaging	Het
Gprin1	T	C	13: 54,738,652	D603G	probably benign	Het
Il16	A	G	7: 83,688,163	S115P	probably benign	Het
Kalrn	C	A	16: 34,314,192	V401L	probably benign	Het
Kcnq4	T	A	4: 120,704,426	K482I	possibly damaging	Het
L3mbtl3	C	T	10: 26,342,617	A114T	unknown	Het
Lig1	G	A	7: 13,311,107		probably benign	Het
Lnx1	G	A	5: 74,620,263	T199M	probably damaging	Het
Mapk13	A	G	17: 28,776,583		probably benign	Het
Mfsd2b	A	T	12: 4,866,538		probably null	Het
Mrpl3	A	G	9: 105,057,065	D137G	probably benign	Het
Muc15	A	G	2: 110,731,699	D160G	probably benign	Het
Myh4	T	C	11: 67,246,543		probably null	Het
Nipa2	T	G	7: 55,932,932	N355T	probably benign	Het
Olfr1396	T	C	11: 49,113,709	N6D	probably damaging	Het
Olfr484	T	C	7: 108,124,634	T210A	probably benign	Het
Olfr749	A	T	14: 50,736,858	Y101*	probably null	Het
Pfkm	G	T	15: 98,123,243		probably null	Het
Ppip5k1	A	G	2: 121,326,846		probably benign	Het
Ppp1r18	A	G	17: 35,867,965	D244G	possibly damaging	Het
Scn2a	T	C	2: 65,671,653	S107P	probably damaging	Het
Scn5a	A	T	9: 119,522,566	I783N	probably damaging	Het
Snx1	A	G	9: 66,094,452	W307R	probably damaging	Het
Stk11ip	G	A	1: 75,534,435	V928M	probably benign	Het
Tgm4	A	G	9: 123,045,036	M114V	probably null	Het
Trpm2	G	A	10: 77,918,909	R1248C	probably benign	Het
Txnrd1	T	C	10: 82,885,046	I347T	possibly damaging	Het
Unc5a	A	G	13: 54,999,503	S106G	probably damaging	Het
Vmn2r85	T	C	10: 130,418,743	M691V	probably benign	Het
Zfp58	T	A	13: 67,491,409	Q321L	probably benign	Het

Other mutations in Olfr644

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01614:Olfr644	APN	7	104068369	missense	probably benign	0.00
IGL02937:Olfr644	APN	7	104068849	missense	probably damaging	0.99
FR4737:Olfr644	UTSW	7	104071292	start gained	probably benign
R0467:Olfr644	UTSW	7	104068125	missense	probably benign	0.07
R1310:Olfr644	UTSW	7	104068598	missense	probably benign
R1457:Olfr644	UTSW	7	104068459	missense	probably damaging	1.00
R1619:Olfr644	UTSW	7	104068531	missense	probably damaging	1.00
R1874:Olfr644	UTSW	7	104068129	missense	probably null	1.00
R2428:Olfr644	UTSW	7	104068468	nonsense	probably null
R2922:Olfr644	UTSW	7	104068587	missense	probably benign	0.09
R2923:Olfr644	UTSW	7	104068587	missense	probably benign	0.09
R3929:Olfr644	UTSW	7	104068584	missense	probably benign	0.06
R4500:Olfr644	UTSW	7	104068195	missense	probably damaging	1.00
R5035:Olfr644	UTSW	7	104068407	missense	possibly damaging	0.95
R5303:Olfr644	UTSW	7	104069032	utr 5 prime	probably benign
R5464:Olfr644	UTSW	7	104068467	missense	possibly damaging	0.72
R5722:Olfr644	UTSW	7	104068723	missense	probably damaging	1.00
R5742:Olfr644	UTSW	7	104068205	missense	probably damaging	0.97
R6874:Olfr644	UTSW	7	104068189	missense	possibly damaging	0.50
R6940:Olfr644	UTSW	7	104068413	missense	possibly damaging	0.82

Posted On

2016-08-02