Incidental Mutation 'IGL03188:Tgm4'
ID 412521
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tgm4
Ensembl Gene ENSMUSG00000025787
Gene Name transglutaminase 4 (prostate)
Synonyms Eapa1, 9530008N10Rik, experimental autoimmune prostatitis antigen 1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL03188
Quality Score
Status
Chromosome 9
Chromosomal Location 122863806-122896623 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 122874101 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 114 (M114V)
Ref Sequence ENSEMBL: ENSMUSP00000026893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026893] [ENSMUST00000215247] [ENSMUST00000217607]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000026893
AA Change: M114V

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000026893
Gene: ENSMUSG00000025787
AA Change: M114V

DomainStartEndE-ValueType
Pfam:Transglut_N 8 118 4e-26 PFAM
TGc 247 340 6.25e-42 SMART
Pfam:Transglut_C 573 670 3e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128572
Predicted Effect noncoding transcript
Transcript: ENSMUST00000171897
Predicted Effect probably benign
Transcript: ENSMUST00000215247
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217036
Predicted Effect probably benign
Transcript: ENSMUST00000217607
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired copulatory plug formation, reduced fertilization and few litters sired. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts18 C A 8: 114,425,656 (GRCm39) C1202F probably damaging Het
Ago2 C T 15: 72,995,182 (GRCm39) V466I probably benign Het
Ank2 C A 3: 126,749,519 (GRCm39) E503D probably damaging Het
Aptx A T 4: 40,695,143 (GRCm39) probably null Het
Aurka A T 2: 172,205,688 (GRCm39) D123E possibly damaging Het
Btaf1 T C 19: 36,926,508 (GRCm39) I60T possibly damaging Het
Ccdc154 A T 17: 25,383,067 (GRCm39) probably null Het
Cct5 T C 15: 31,598,148 (GRCm39) N55S probably benign Het
Cntnap3 A G 13: 64,929,559 (GRCm39) S547P probably damaging Het
Efl1 T A 7: 82,320,909 (GRCm39) I114N probably damaging Het
Gprin1 T C 13: 54,886,465 (GRCm39) D603G probably benign Het
Il16 A G 7: 83,337,371 (GRCm39) S115P probably benign Het
Kalrn C A 16: 34,134,562 (GRCm39) V401L probably benign Het
Kcnq4 T A 4: 120,561,623 (GRCm39) K482I possibly damaging Het
L3mbtl3 C T 10: 26,218,515 (GRCm39) A114T unknown Het
Lig1 G A 7: 13,045,032 (GRCm39) probably benign Het
Lnx1 G A 5: 74,780,924 (GRCm39) T199M probably damaging Het
Mapk13 A G 17: 28,995,557 (GRCm39) probably benign Het
Mfsd2b A T 12: 4,916,538 (GRCm39) probably null Het
Mrpl3 A G 9: 104,934,264 (GRCm39) D137G probably benign Het
Muc15 A G 2: 110,562,044 (GRCm39) D160G probably benign Het
Myh4 T C 11: 67,137,369 (GRCm39) probably null Het
Nipa2 T G 7: 55,582,680 (GRCm39) N355T probably benign Het
Or11h4 A T 14: 50,974,315 (GRCm39) Y101* probably null Het
Or2v2 T C 11: 49,004,536 (GRCm39) N6D probably damaging Het
Or51a43 A G 7: 103,717,945 (GRCm39) S98P possibly damaging Het
Or5p60 T C 7: 107,723,841 (GRCm39) T210A probably benign Het
Pfkm G T 15: 98,021,124 (GRCm39) probably null Het
Ppip5k1 A G 2: 121,157,327 (GRCm39) probably benign Het
Ppp1r18 A G 17: 36,178,857 (GRCm39) D244G possibly damaging Het
Rimoc1 A G 15: 4,018,187 (GRCm39) Y163H probably damaging Het
Scn2a T C 2: 65,501,997 (GRCm39) S107P probably damaging Het
Scn5a A T 9: 119,351,632 (GRCm39) I783N probably damaging Het
Snx1 A G 9: 66,001,734 (GRCm39) W307R probably damaging Het
Spata31g1 A G 4: 42,971,225 (GRCm39) Y186C possibly damaging Het
Stk11ip G A 1: 75,511,079 (GRCm39) V928M probably benign Het
Trpm2 G A 10: 77,754,743 (GRCm39) R1248C probably benign Het
Txnrd1 T C 10: 82,720,880 (GRCm39) I347T possibly damaging Het
Unc5a A G 13: 55,147,316 (GRCm39) S106G probably damaging Het
Vmn2r85 T C 10: 130,254,612 (GRCm39) M691V probably benign Het
Zfp58 T A 13: 67,639,528 (GRCm39) Q321L probably benign Het
Other mutations in Tgm4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00432:Tgm4 APN 9 122,891,447 (GRCm39) unclassified probably benign
IGL01402:Tgm4 APN 9 122,880,519 (GRCm39) missense possibly damaging 0.82
IGL02000:Tgm4 APN 9 122,885,531 (GRCm39) missense probably damaging 1.00
IGL02120:Tgm4 APN 9 122,875,594 (GRCm39) missense probably damaging 0.98
IGL03130:Tgm4 APN 9 122,885,580 (GRCm39) missense probably damaging 1.00
R0329:Tgm4 UTSW 9 122,877,622 (GRCm39) critical splice donor site probably null
R0480:Tgm4 UTSW 9 122,891,484 (GRCm39) missense probably benign
R0644:Tgm4 UTSW 9 122,880,523 (GRCm39) missense probably damaging 1.00
R0990:Tgm4 UTSW 9 122,875,576 (GRCm39) missense probably benign 0.02
R1604:Tgm4 UTSW 9 122,874,129 (GRCm39) missense probably benign 0.39
R1644:Tgm4 UTSW 9 122,880,481 (GRCm39) missense probably damaging 1.00
R2056:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2058:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2059:Tgm4 UTSW 9 122,890,835 (GRCm39) missense probably damaging 1.00
R2076:Tgm4 UTSW 9 122,880,160 (GRCm39) missense probably benign 0.24
R2437:Tgm4 UTSW 9 122,877,614 (GRCm39) nonsense probably null
R4392:Tgm4 UTSW 9 122,895,817 (GRCm39) missense probably benign 0.10
R4407:Tgm4 UTSW 9 122,885,595 (GRCm39) missense probably damaging 1.00
R4752:Tgm4 UTSW 9 122,880,451 (GRCm39) missense probably damaging 1.00
R5288:Tgm4 UTSW 9 122,885,559 (GRCm39) missense probably damaging 1.00
R5365:Tgm4 UTSW 9 122,895,866 (GRCm39) missense probably damaging 1.00
R5386:Tgm4 UTSW 9 122,885,559 (GRCm39) missense probably damaging 1.00
R5790:Tgm4 UTSW 9 122,890,808 (GRCm39) missense probably damaging 0.98
R5890:Tgm4 UTSW 9 122,890,703 (GRCm39) missense probably damaging 1.00
R6102:Tgm4 UTSW 9 122,885,600 (GRCm39) missense probably benign
R6358:Tgm4 UTSW 9 122,885,583 (GRCm39) missense probably damaging 1.00
R6956:Tgm4 UTSW 9 122,893,768 (GRCm39) missense possibly damaging 0.93
R6966:Tgm4 UTSW 9 122,880,207 (GRCm39) missense possibly damaging 0.68
R7091:Tgm4 UTSW 9 122,869,525 (GRCm39) missense probably damaging 1.00
R7258:Tgm4 UTSW 9 122,891,556 (GRCm39) missense probably benign 0.02
R7313:Tgm4 UTSW 9 122,891,556 (GRCm39) missense probably benign 0.02
R7369:Tgm4 UTSW 9 122,885,749 (GRCm39) critical splice donor site probably null
R7802:Tgm4 UTSW 9 122,880,401 (GRCm39) intron probably benign
R8219:Tgm4 UTSW 9 122,874,117 (GRCm39) missense probably benign
R8787:Tgm4 UTSW 9 122,890,910 (GRCm39) missense probably damaging 1.00
R8936:Tgm4 UTSW 9 122,869,541 (GRCm39) missense possibly damaging 0.92
R9045:Tgm4 UTSW 9 122,877,616 (GRCm39) missense possibly damaging 0.94
R9328:Tgm4 UTSW 9 122,885,697 (GRCm39) missense possibly damaging 0.93
R9359:Tgm4 UTSW 9 122,881,837 (GRCm39) missense probably damaging 1.00
R9403:Tgm4 UTSW 9 122,881,837 (GRCm39) missense probably damaging 1.00
R9471:Tgm4 UTSW 9 122,869,444 (GRCm39) missense probably benign
R9746:Tgm4 UTSW 9 122,875,634 (GRCm39) missense possibly damaging 0.95
Posted On 2016-08-02