Incidental Mutation 'IGL03189:Vmn2r4'
ID 412549
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r4
Ensembl Gene ENSMUSG00000092049
Gene Name vomeronasal 2, receptor 4
Synonyms EG637053
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # IGL03189
Quality Score
Status
Chromosome 3
Chromosomal Location 64295982-64322741 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 64296589 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 732 (R732L)
Ref Sequence ENSEMBL: ENSMUSP00000135228 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170280] [ENSMUST00000175724]
AlphaFold K7N784
Predicted Effect possibly damaging
Transcript: ENSMUST00000170280
AA Change: R643L

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000127513
Gene: ENSMUSG00000092049
AA Change: R643L

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 416 2.7e-72 PFAM
Pfam:Peripla_BP_6 61 240 1.9e-9 PFAM
Pfam:NCD3G 458 511 1.1e-17 PFAM
Pfam:7tm_3 542 779 1.8e-75 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000175724
AA Change: R732L

PolyPhen 2 Score 0.893 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000135228
Gene: ENSMUSG00000092049
AA Change: R732L

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 88 505 2.3e-75 PFAM
Pfam:NCD3G 547 600 4.7e-17 PFAM
Pfam:7tm_3 633 867 8.2e-47 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A G 5: 8,895,814 (GRCm39) T916A probably benign Het
Adam22 A T 5: 8,161,897 (GRCm39) Y50* probably null Het
Adprs T C 4: 126,211,087 (GRCm39) probably benign Het
Ahnak G A 19: 8,988,603 (GRCm39) V3296M possibly damaging Het
Bfar A G 16: 13,505,365 (GRCm39) D125G possibly damaging Het
Bmp3 A T 5: 99,020,579 (GRCm39) Q334L probably benign Het
Camsap2 A T 1: 136,209,400 (GRCm39) D697E probably damaging Het
Car11 A G 7: 45,351,879 (GRCm39) T103A probably damaging Het
Cecr2 T A 6: 120,739,391 (GRCm39) S1373T probably benign Het
Cenpm A G 15: 82,118,634 (GRCm39) V160A possibly damaging Het
Chl1 A T 6: 103,660,168 (GRCm39) I365F possibly damaging Het
Col20a1 C T 2: 180,651,200 (GRCm39) Q1089* probably null Het
Csf1r A T 18: 61,239,058 (GRCm39) T13S probably benign Het
Fam13a T C 6: 58,933,843 (GRCm39) E249G probably damaging Het
Fgd6 G A 10: 93,880,318 (GRCm39) V391I probably benign Het
Fhdc1 G A 3: 84,362,368 (GRCm39) probably benign Het
Fn3krp T C 11: 121,320,456 (GRCm39) I267T probably damaging Het
Fras1 A T 5: 96,890,930 (GRCm39) I2820F probably benign Het
Fyb2 A G 4: 104,872,939 (GRCm39) I771V probably damaging Het
Gata3os A G 2: 9,888,634 (GRCm39) probably benign Het
Glis1 A G 4: 107,472,248 (GRCm39) Y275C probably damaging Het
Hdgf A G 3: 87,820,735 (GRCm39) T62A possibly damaging Het
Hsd17b3 C T 13: 64,210,901 (GRCm39) probably null Het
Ift56 C T 6: 38,402,166 (GRCm39) P553S probably benign Het
Iqgap1 T A 7: 80,363,590 (GRCm39) Y1655F probably benign Het
Izumo1 A G 7: 45,274,588 (GRCm39) D181G probably damaging Het
Lrp2 T C 2: 69,268,822 (GRCm39) probably benign Het
Mark1 T C 1: 184,651,890 (GRCm39) N95S probably damaging Het
Mbd5 A G 2: 49,147,763 (GRCm39) K658E probably damaging Het
Mcm6 C T 1: 128,272,039 (GRCm39) D453N probably damaging Het
Mfsd14a T C 3: 116,435,504 (GRCm39) D187G probably benign Het
Mrpl19 G T 6: 81,938,974 (GRCm39) S276* probably null Het
Ncoa2 G A 1: 13,260,360 (GRCm39) T105M probably damaging Het
Nop14 A G 5: 34,807,972 (GRCm39) probably benign Het
Or2ah1 A G 2: 85,653,902 (GRCm39) T196A probably benign Het
Or2aj5 T C 16: 19,425,341 (GRCm39) T26A probably benign Het
Or5w19 G A 2: 87,698,559 (GRCm39) A75T possibly damaging Het
Otud7b G A 3: 96,062,795 (GRCm39) S678N probably benign Het
Pcdhb6 G A 18: 37,469,205 (GRCm39) V25M probably damaging Het
Prpf39 G T 12: 65,090,076 (GRCm39) G5* probably null Het
Serpinb9d T C 13: 33,386,895 (GRCm39) V321A probably damaging Het
Sh2b1 A G 7: 126,067,702 (GRCm39) S613P possibly damaging Het
Snx30 T C 4: 59,857,452 (GRCm39) I55T probably benign Het
Spata13 T C 14: 60,929,063 (GRCm39) I207T possibly damaging Het
Suco T C 1: 161,684,906 (GRCm39) probably benign Het
Svs5 A G 2: 164,079,032 (GRCm39) S292P possibly damaging Het
Tcam1 A G 11: 106,176,212 (GRCm39) I313V probably benign Het
Tmem45a A T 16: 56,631,936 (GRCm39) Y227* probably null Het
Tnfsf15 A G 4: 63,648,289 (GRCm39) probably benign Het
Wdr7 C T 18: 63,893,672 (GRCm39) T602I probably benign Het
Other mutations in Vmn2r4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01310:Vmn2r4 APN 3 64,317,200 (GRCm39) splice site probably null
IGL01448:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01452:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01454:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01456:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01463:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01467:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01468:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01470:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01476:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01481:Vmn2r4 APN 3 64,313,816 (GRCm39) missense probably damaging 0.99
IGL01534:Vmn2r4 APN 3 64,313,844 (GRCm39) missense probably damaging 1.00
IGL01636:Vmn2r4 APN 3 64,313,657 (GRCm39) missense probably benign 0.21
IGL01879:Vmn2r4 APN 3 64,298,431 (GRCm39) missense probably damaging 1.00
IGL02147:Vmn2r4 APN 3 64,305,782 (GRCm39) splice site probably benign
IGL02276:Vmn2r4 APN 3 64,313,877 (GRCm39) missense possibly damaging 0.95
IGL02432:Vmn2r4 APN 3 64,313,821 (GRCm39) missense probably benign 0.38
IGL02533:Vmn2r4 APN 3 64,305,840 (GRCm39) nonsense probably null
IGL02655:Vmn2r4 APN 3 64,305,886 (GRCm39) missense probably damaging 0.97
IGL02666:Vmn2r4 APN 3 64,296,433 (GRCm39) missense probably benign 0.10
IGL02902:Vmn2r4 APN 3 64,314,337 (GRCm39) missense probably benign 0.22
IGL03250:Vmn2r4 APN 3 64,314,063 (GRCm39) missense probably damaging 1.00
IGL03271:Vmn2r4 APN 3 64,305,850 (GRCm39) missense probably benign 0.01
R0310:Vmn2r4 UTSW 3 64,296,855 (GRCm39) nonsense probably null
R0504:Vmn2r4 UTSW 3 64,296,784 (GRCm39) missense probably damaging 1.00
R1546:Vmn2r4 UTSW 3 64,314,309 (GRCm39) missense probably damaging 1.00
R1562:Vmn2r4 UTSW 3 64,296,865 (GRCm39) missense probably damaging 0.98
R1863:Vmn2r4 UTSW 3 64,314,410 (GRCm39) missense probably benign 0.33
R1873:Vmn2r4 UTSW 3 64,298,479 (GRCm39) missense possibly damaging 0.93
R1939:Vmn2r4 UTSW 3 64,305,976 (GRCm39) missense probably benign 0.00
R2103:Vmn2r4 UTSW 3 64,322,704 (GRCm39) missense possibly damaging 0.48
R3083:Vmn2r4 UTSW 3 64,296,788 (GRCm39) missense probably damaging 1.00
R3687:Vmn2r4 UTSW 3 64,296,896 (GRCm39) missense possibly damaging 0.93
R3707:Vmn2r4 UTSW 3 64,296,895 (GRCm39) missense probably damaging 0.99
R3963:Vmn2r4 UTSW 3 64,322,572 (GRCm39) missense probably damaging 0.99
R4428:Vmn2r4 UTSW 3 64,322,590 (GRCm39) missense probably damaging 1.00
R4710:Vmn2r4 UTSW 3 64,317,201 (GRCm39) critical splice donor site probably null
R4737:Vmn2r4 UTSW 3 64,317,384 (GRCm39) missense probably damaging 1.00
R4767:Vmn2r4 UTSW 3 64,298,397 (GRCm39) missense probably damaging 0.99
R4776:Vmn2r4 UTSW 3 64,296,082 (GRCm39) missense probably damaging 0.96
R4834:Vmn2r4 UTSW 3 64,317,484 (GRCm39) missense probably benign 0.40
R4893:Vmn2r4 UTSW 3 64,313,676 (GRCm39) missense probably damaging 0.96
R4908:Vmn2r4 UTSW 3 64,296,476 (GRCm39) missense possibly damaging 0.59
R5049:Vmn2r4 UTSW 3 64,306,019 (GRCm39) splice site probably null
R5092:Vmn2r4 UTSW 3 64,298,373 (GRCm39) missense probably benign 0.01
R5234:Vmn2r4 UTSW 3 64,305,878 (GRCm39) missense possibly damaging 0.88
R5240:Vmn2r4 UTSW 3 64,314,358 (GRCm39) missense possibly damaging 0.53
R5704:Vmn2r4 UTSW 3 64,317,370 (GRCm39) missense probably benign 0.03
R5897:Vmn2r4 UTSW 3 64,322,687 (GRCm39) nonsense probably null
R5907:Vmn2r4 UTSW 3 64,298,487 (GRCm39) missense probably damaging 0.99
R5924:Vmn2r4 UTSW 3 64,296,685 (GRCm39) missense probably damaging 1.00
R6145:Vmn2r4 UTSW 3 64,314,364 (GRCm39) missense probably benign 0.00
R6191:Vmn2r4 UTSW 3 64,322,702 (GRCm39) missense probably benign 0.34
R6192:Vmn2r4 UTSW 3 64,322,699 (GRCm39) missense probably benign 0.00
R6207:Vmn2r4 UTSW 3 64,313,926 (GRCm39) missense probably damaging 1.00
R6457:Vmn2r4 UTSW 3 64,317,378 (GRCm39) missense probably damaging 1.00
R6533:Vmn2r4 UTSW 3 64,322,519 (GRCm39) missense probably benign
R6545:Vmn2r4 UTSW 3 64,313,777 (GRCm39) missense possibly damaging 0.50
R6594:Vmn2r4 UTSW 3 64,296,731 (GRCm39) missense probably damaging 1.00
R7049:Vmn2r4 UTSW 3 64,296,550 (GRCm39) missense probably benign 0.14
R7150:Vmn2r4 UTSW 3 64,305,898 (GRCm39) missense probably benign 0.01
R7187:Vmn2r4 UTSW 3 64,322,681 (GRCm39) missense probably benign 0.00
R7363:Vmn2r4 UTSW 3 64,314,432 (GRCm39) missense probably damaging 1.00
R7477:Vmn2r4 UTSW 3 64,305,850 (GRCm39) missense probably benign 0.01
R7675:Vmn2r4 UTSW 3 64,322,657 (GRCm39) missense probably benign 0.01
R7858:Vmn2r4 UTSW 3 64,317,226 (GRCm39) missense probably benign 0.00
R7888:Vmn2r4 UTSW 3 64,313,943 (GRCm39) missense probably damaging 0.99
R8678:Vmn2r4 UTSW 3 64,314,391 (GRCm39) missense probably benign
R8743:Vmn2r4 UTSW 3 64,317,247 (GRCm39) missense possibly damaging 0.95
R8841:Vmn2r4 UTSW 3 64,314,058 (GRCm39) missense probably damaging 0.97
R9671:Vmn2r4 UTSW 3 64,317,271 (GRCm39) missense probably benign 0.00
R9778:Vmn2r4 UTSW 3 64,322,497 (GRCm39) missense probably benign 0.15
X0019:Vmn2r4 UTSW 3 64,314,057 (GRCm39) missense probably damaging 0.99
Posted On 2016-08-02