Incidental Mutation 'IGL03189:Svs5'
ID 412551
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Svs5
Ensembl Gene ENSMUSG00000017004
Gene Name seminal vesicle secretory protein 5
Synonyms seminal vesicle protein F, Svp-1, Svp1, SVS V, Svp5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL03189
Quality Score
Status
Chromosome 2
Chromosomal Location 164174685-164176314 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 164079032 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 292 (S292P)
Ref Sequence ENSEMBL: ENSMUSP00000104999 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044953] [ENSMUST00000109374]
AlphaFold P30933
Predicted Effect possibly damaging
Transcript: ENSMUST00000044953
AA Change: S292P

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000042389
Gene: ENSMUSG00000040132
AA Change: S292P

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:SVS_QK 110 121 1.2e-6 PFAM
Pfam:SVS_QK 122 137 3.9e-3 PFAM
Pfam:SVS_QK 139 149 1.3e-5 PFAM
Pfam:SVS_QK 151 166 8.4e-4 PFAM
Pfam:SVS_QK 168 179 5.3e-6 PFAM
Pfam:SVS_QK 180 195 3.9e-3 PFAM
Pfam:SVS_QK 197 207 1.3e-5 PFAM
Pfam:SVS_QK 210 221 8.8e-5 PFAM
Pfam:SVS_QK 225 236 7.7e-6 PFAM
Pfam:SVS_QK 238 249 6.1e-6 PFAM
Pfam:SVS_QK 249 260 5.2e-4 PFAM
Pfam:SVS_QK 262 272 3.1e-5 PFAM
Pfam:SVS_QK 323 334 6.7e-5 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000109374
AA Change: S292P

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000104999
Gene: ENSMUSG00000040132
AA Change: S292P

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:SVS_QK 110 121 1.2e-6 PFAM
Pfam:SVS_QK 122 137 3.9e-3 PFAM
Pfam:SVS_QK 139 149 1.3e-5 PFAM
Pfam:SVS_QK 151 166 8.4e-4 PFAM
Pfam:SVS_QK 168 179 5.3e-6 PFAM
Pfam:SVS_QK 180 195 3.9e-3 PFAM
Pfam:SVS_QK 197 207 1.3e-5 PFAM
Pfam:SVS_QK 210 221 8.8e-5 PFAM
Pfam:SVS_QK 225 236 7.7e-6 PFAM
Pfam:SVS_QK 238 249 6.1e-6 PFAM
Pfam:SVS_QK 249 260 5.2e-4 PFAM
Pfam:SVS_QK 262 272 3.1e-5 PFAM
Pfam:SVS_QK 323 334 6.7e-5 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A G 5: 8,895,814 (GRCm39) T916A probably benign Het
Adam22 A T 5: 8,161,897 (GRCm39) Y50* probably null Het
Adprs T C 4: 126,211,087 (GRCm39) probably benign Het
Ahnak G A 19: 8,988,603 (GRCm39) V3296M possibly damaging Het
Bfar A G 16: 13,505,365 (GRCm39) D125G possibly damaging Het
Bmp3 A T 5: 99,020,579 (GRCm39) Q334L probably benign Het
Camsap2 A T 1: 136,209,400 (GRCm39) D697E probably damaging Het
Car11 A G 7: 45,351,879 (GRCm39) T103A probably damaging Het
Cecr2 T A 6: 120,739,391 (GRCm39) S1373T probably benign Het
Cenpm A G 15: 82,118,634 (GRCm39) V160A possibly damaging Het
Chl1 A T 6: 103,660,168 (GRCm39) I365F possibly damaging Het
Col20a1 C T 2: 180,651,200 (GRCm39) Q1089* probably null Het
Csf1r A T 18: 61,239,058 (GRCm39) T13S probably benign Het
Fam13a T C 6: 58,933,843 (GRCm39) E249G probably damaging Het
Fgd6 G A 10: 93,880,318 (GRCm39) V391I probably benign Het
Fhdc1 G A 3: 84,362,368 (GRCm39) probably benign Het
Fn3krp T C 11: 121,320,456 (GRCm39) I267T probably damaging Het
Fras1 A T 5: 96,890,930 (GRCm39) I2820F probably benign Het
Fyb2 A G 4: 104,872,939 (GRCm39) I771V probably damaging Het
Gata3os A G 2: 9,888,634 (GRCm39) probably benign Het
Glis1 A G 4: 107,472,248 (GRCm39) Y275C probably damaging Het
Hdgf A G 3: 87,820,735 (GRCm39) T62A possibly damaging Het
Hsd17b3 C T 13: 64,210,901 (GRCm39) probably null Het
Ift56 C T 6: 38,402,166 (GRCm39) P553S probably benign Het
Iqgap1 T A 7: 80,363,590 (GRCm39) Y1655F probably benign Het
Izumo1 A G 7: 45,274,588 (GRCm39) D181G probably damaging Het
Lrp2 T C 2: 69,268,822 (GRCm39) probably benign Het
Mark1 T C 1: 184,651,890 (GRCm39) N95S probably damaging Het
Mbd5 A G 2: 49,147,763 (GRCm39) K658E probably damaging Het
Mcm6 C T 1: 128,272,039 (GRCm39) D453N probably damaging Het
Mfsd14a T C 3: 116,435,504 (GRCm39) D187G probably benign Het
Mrpl19 G T 6: 81,938,974 (GRCm39) S276* probably null Het
Ncoa2 G A 1: 13,260,360 (GRCm39) T105M probably damaging Het
Nop14 A G 5: 34,807,972 (GRCm39) probably benign Het
Or2ah1 A G 2: 85,653,902 (GRCm39) T196A probably benign Het
Or2aj5 T C 16: 19,425,341 (GRCm39) T26A probably benign Het
Or5w19 G A 2: 87,698,559 (GRCm39) A75T possibly damaging Het
Otud7b G A 3: 96,062,795 (GRCm39) S678N probably benign Het
Pcdhb6 G A 18: 37,469,205 (GRCm39) V25M probably damaging Het
Prpf39 G T 12: 65,090,076 (GRCm39) G5* probably null Het
Serpinb9d T C 13: 33,386,895 (GRCm39) V321A probably damaging Het
Sh2b1 A G 7: 126,067,702 (GRCm39) S613P possibly damaging Het
Snx30 T C 4: 59,857,452 (GRCm39) I55T probably benign Het
Spata13 T C 14: 60,929,063 (GRCm39) I207T possibly damaging Het
Suco T C 1: 161,684,906 (GRCm39) probably benign Het
Tcam1 A G 11: 106,176,212 (GRCm39) I313V probably benign Het
Tmem45a A T 16: 56,631,936 (GRCm39) Y227* probably null Het
Tnfsf15 A G 4: 63,648,289 (GRCm39) probably benign Het
Vmn2r4 C A 3: 64,296,589 (GRCm39) R732L possibly damaging Het
Wdr7 C T 18: 63,893,672 (GRCm39) T602I probably benign Het
Other mutations in Svs5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Svs5 APN 2 164,078,962 (GRCm39) missense possibly damaging 0.86
IGL01722:Svs5 APN 2 164,079,446 (GRCm39) missense possibly damaging 0.71
IGL03378:Svs5 APN 2 164,175,260 (GRCm39) missense probably benign 0.00
R0781:Svs5 UTSW 2 164,175,507 (GRCm39) missense probably benign 0.16
R1110:Svs5 UTSW 2 164,175,507 (GRCm39) missense probably benign 0.16
R1276:Svs5 UTSW 2 164,079,168 (GRCm39) missense possibly damaging 0.95
R1541:Svs5 UTSW 2 164,078,929 (GRCm39) missense possibly damaging 0.71
R1590:Svs5 UTSW 2 164,079,578 (GRCm39) missense possibly damaging 0.86
R3103:Svs5 UTSW 2 164,175,313 (GRCm39) missense probably benign 0.00
R3946:Svs5 UTSW 2 164,079,047 (GRCm39) missense probably benign 0.01
R3965:Svs5 UTSW 2 164,079,662 (GRCm39) missense possibly damaging 0.53
R4075:Svs5 UTSW 2 164,079,238 (GRCm39) missense probably benign 0.01
R4632:Svs5 UTSW 2 164,079,667 (GRCm39) missense probably benign 0.40
R4732:Svs5 UTSW 2 164,079,043 (GRCm39) missense possibly damaging 0.87
R4733:Svs5 UTSW 2 164,079,043 (GRCm39) missense possibly damaging 0.87
R4839:Svs5 UTSW 2 164,078,806 (GRCm39) missense probably benign 0.40
R5706:Svs5 UTSW 2 164,079,589 (GRCm39) missense possibly damaging 0.53
R6936:Svs5 UTSW 2 164,079,548 (GRCm39) missense possibly damaging 0.86
R7052:Svs5 UTSW 2 164,080,126 (GRCm39) missense unknown
R7338:Svs5 UTSW 2 164,174,728 (GRCm39) missense possibly damaging 0.96
R7836:Svs5 UTSW 2 164,079,500 (GRCm39) missense possibly damaging 0.86
R8017:Svs5 UTSW 2 164,175,341 (GRCm39) missense possibly damaging 0.86
R8019:Svs5 UTSW 2 164,175,341 (GRCm39) missense possibly damaging 0.86
R8035:Svs5 UTSW 2 164,079,053 (GRCm39) missense probably benign 0.18
R8100:Svs5 UTSW 2 164,079,712 (GRCm39) missense probably benign 0.08
R8187:Svs5 UTSW 2 164,079,692 (GRCm39) missense possibly damaging 0.88
R8310:Svs5 UTSW 2 164,080,091 (GRCm39) missense probably damaging 1.00
R8312:Svs5 UTSW 2 164,080,091 (GRCm39) missense probably damaging 1.00
R9089:Svs5 UTSW 2 164,079,341 (GRCm39) missense probably benign 0.27
R9156:Svs5 UTSW 2 164,079,509 (GRCm39) missense probably benign 0.32
R9545:Svs5 UTSW 2 164,079,313 (GRCm39) missense possibly damaging 0.52
R9790:Svs5 UTSW 2 164,078,918 (GRCm39) nonsense probably null
R9791:Svs5 UTSW 2 164,078,918 (GRCm39) nonsense probably null
Z1176:Svs5 UTSW 2 164,174,711 (GRCm39) missense possibly damaging 0.73
Posted On 2016-08-02