Incidental Mutation 'IGL03189:Or2aj5'
ID 412552
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2aj5
Ensembl Gene ENSMUSG00000062245
Gene Name olfactory receptor family 2 subfamily AJ member 5
Synonyms Olfr170, MOR273-2, GA_x54KRFPKG5P-16052703-16051765
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # IGL03189
Quality Score
Chromosome 16
Chromosomal Location 19424475-19425416 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19425341 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 26 (T26A)
Ref Sequence ENSEMBL: ENSMUSP00000151806 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078603] [ENSMUST00000206562] [ENSMUST00000218837]
AlphaFold Q8VGL6
Predicted Effect probably benign
Transcript: ENSMUST00000078603
AA Change: T25A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000077674
Gene: ENSMUSG00000062245
AA Change: T25A

Pfam:7tm_4 29 308 1.5e-43 PFAM
Pfam:7tm_1 41 290 2.4e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000206562
AA Change: T25A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000218837
AA Change: T26A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A G 5: 8,895,814 (GRCm39) T916A probably benign Het
Adam22 A T 5: 8,161,897 (GRCm39) Y50* probably null Het
Adprs T C 4: 126,211,087 (GRCm39) probably benign Het
Ahnak G A 19: 8,988,603 (GRCm39) V3296M possibly damaging Het
Bfar A G 16: 13,505,365 (GRCm39) D125G possibly damaging Het
Bmp3 A T 5: 99,020,579 (GRCm39) Q334L probably benign Het
Camsap2 A T 1: 136,209,400 (GRCm39) D697E probably damaging Het
Car11 A G 7: 45,351,879 (GRCm39) T103A probably damaging Het
Cecr2 T A 6: 120,739,391 (GRCm39) S1373T probably benign Het
Cenpm A G 15: 82,118,634 (GRCm39) V160A possibly damaging Het
Chl1 A T 6: 103,660,168 (GRCm39) I365F possibly damaging Het
Col20a1 C T 2: 180,651,200 (GRCm39) Q1089* probably null Het
Csf1r A T 18: 61,239,058 (GRCm39) T13S probably benign Het
Fam13a T C 6: 58,933,843 (GRCm39) E249G probably damaging Het
Fgd6 G A 10: 93,880,318 (GRCm39) V391I probably benign Het
Fhdc1 G A 3: 84,362,368 (GRCm39) probably benign Het
Fn3krp T C 11: 121,320,456 (GRCm39) I267T probably damaging Het
Fras1 A T 5: 96,890,930 (GRCm39) I2820F probably benign Het
Fyb2 A G 4: 104,872,939 (GRCm39) I771V probably damaging Het
Gata3os A G 2: 9,888,634 (GRCm39) probably benign Het
Glis1 A G 4: 107,472,248 (GRCm39) Y275C probably damaging Het
Hdgf A G 3: 87,820,735 (GRCm39) T62A possibly damaging Het
Hsd17b3 C T 13: 64,210,901 (GRCm39) probably null Het
Ift56 C T 6: 38,402,166 (GRCm39) P553S probably benign Het
Iqgap1 T A 7: 80,363,590 (GRCm39) Y1655F probably benign Het
Izumo1 A G 7: 45,274,588 (GRCm39) D181G probably damaging Het
Lrp2 T C 2: 69,268,822 (GRCm39) probably benign Het
Mark1 T C 1: 184,651,890 (GRCm39) N95S probably damaging Het
Mbd5 A G 2: 49,147,763 (GRCm39) K658E probably damaging Het
Mcm6 C T 1: 128,272,039 (GRCm39) D453N probably damaging Het
Mfsd14a T C 3: 116,435,504 (GRCm39) D187G probably benign Het
Mrpl19 G T 6: 81,938,974 (GRCm39) S276* probably null Het
Ncoa2 G A 1: 13,260,360 (GRCm39) T105M probably damaging Het
Nop14 A G 5: 34,807,972 (GRCm39) probably benign Het
Or2ah1 A G 2: 85,653,902 (GRCm39) T196A probably benign Het
Or5w19 G A 2: 87,698,559 (GRCm39) A75T possibly damaging Het
Otud7b G A 3: 96,062,795 (GRCm39) S678N probably benign Het
Pcdhb6 G A 18: 37,469,205 (GRCm39) V25M probably damaging Het
Prpf39 G T 12: 65,090,076 (GRCm39) G5* probably null Het
Serpinb9d T C 13: 33,386,895 (GRCm39) V321A probably damaging Het
Sh2b1 A G 7: 126,067,702 (GRCm39) S613P possibly damaging Het
Snx30 T C 4: 59,857,452 (GRCm39) I55T probably benign Het
Spata13 T C 14: 60,929,063 (GRCm39) I207T possibly damaging Het
Suco T C 1: 161,684,906 (GRCm39) probably benign Het
Svs5 A G 2: 164,079,032 (GRCm39) S292P possibly damaging Het
Tcam1 A G 11: 106,176,212 (GRCm39) I313V probably benign Het
Tmem45a A T 16: 56,631,936 (GRCm39) Y227* probably null Het
Tnfsf15 A G 4: 63,648,289 (GRCm39) probably benign Het
Vmn2r4 C A 3: 64,296,589 (GRCm39) R732L possibly damaging Het
Wdr7 C T 18: 63,893,672 (GRCm39) T602I probably benign Het
Other mutations in Or2aj5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01671:Or2aj5 APN 16 19,424,671 (GRCm39) missense probably benign 0.00
IGL02002:Or2aj5 APN 16 19,425,300 (GRCm39) missense possibly damaging 0.91
IGL02537:Or2aj5 APN 16 19,424,549 (GRCm39) missense probably damaging 1.00
IGL02881:Or2aj5 APN 16 19,425,050 (GRCm39) missense probably damaging 1.00
R0012:Or2aj5 UTSW 16 19,425,190 (GRCm39) missense probably benign 0.30
R0619:Or2aj5 UTSW 16 19,425,022 (GRCm39) missense probably damaging 1.00
R0764:Or2aj5 UTSW 16 19,425,182 (GRCm39) missense probably damaging 1.00
R1387:Or2aj5 UTSW 16 19,424,777 (GRCm39) missense probably damaging 1.00
R1430:Or2aj5 UTSW 16 19,424,752 (GRCm39) missense probably damaging 1.00
R1503:Or2aj5 UTSW 16 19,425,062 (GRCm39) missense probably benign 0.19
R1878:Or2aj5 UTSW 16 19,424,501 (GRCm39) missense probably benign
R1989:Or2aj5 UTSW 16 19,425,407 (GRCm39) missense probably benign 0.00
R2012:Or2aj5 UTSW 16 19,424,881 (GRCm39) missense probably benign 0.22
R3890:Or2aj5 UTSW 16 19,425,205 (GRCm39) missense probably damaging 1.00
R3891:Or2aj5 UTSW 16 19,425,205 (GRCm39) missense probably damaging 1.00
R5591:Or2aj5 UTSW 16 19,424,608 (GRCm39) missense probably damaging 1.00
R6158:Or2aj5 UTSW 16 19,424,675 (GRCm39) missense probably damaging 1.00
R6297:Or2aj5 UTSW 16 19,424,680 (GRCm39) missense possibly damaging 0.81
R6512:Or2aj5 UTSW 16 19,425,109 (GRCm39) missense probably damaging 1.00
R6962:Or2aj5 UTSW 16 19,424,672 (GRCm39) missense probably benign 0.00
R7252:Or2aj5 UTSW 16 19,425,249 (GRCm39) missense probably damaging 0.99
R7605:Or2aj5 UTSW 16 19,425,022 (GRCm39) missense probably damaging 1.00
R7687:Or2aj5 UTSW 16 19,424,485 (GRCm39) missense probably benign
R8302:Or2aj5 UTSW 16 19,425,116 (GRCm39) missense probably benign 0.05
R8991:Or2aj5 UTSW 16 19,424,511 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02