Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03189:Olfr1018'

412569

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr1018

Ensembl Gene

ENSMUSG00000043892

Gene Name

olfactory receptor 1018

Synonyms

GA_x6K02T2Q125-47301584-47302519, MOR260-5

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.511) question?

Stock #

IGL03189

Quality Score

Status

Chromosome

Chromosomal Location

85818479-85824221 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 85823558 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 196 (T196A)

Ref Sequence

ENSEMBL: ENSMUSP00000151090 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000054201] [ENSMUST00000214416]

AlphaFold

A2ASV3

Predicted Effect

probably benign
Transcript: ENSMUST00000054201
AA Change: T196A

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000050833
Gene: ENSMUSG00000043892
AA Change: T196A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	4.1e-59	PFAM
Pfam:7tm_1	42	291	1.2e-25	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214416
AA Change: T196A

PolyPhen 2 Score 0.273 (Sensitivity: 0.91; Specificity: 0.88)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930412O13Rik	A	G	2: 9,883,823 (GRCm38)		probably benign	Het
Abcb1b	A	G	5: 8,845,814 (GRCm38)	T916A	probably benign	Het
Adam22	A	T	5: 8,111,897 (GRCm38)	Y50*	probably null	Het
Adprhl2	T	C	4: 126,317,294 (GRCm38)		probably benign	Het
Ahnak	G	A	19: 9,011,239 (GRCm38)	V3296M	possibly damaging	Het
Bfar	A	G	16: 13,687,501 (GRCm38)	D125G	possibly damaging	Het
Bmp3	A	T	5: 98,872,720 (GRCm38)	Q334L	probably benign	Het
Camsap2	A	T	1: 136,281,662 (GRCm38)	D697E	probably damaging	Het
Car11	A	G	7: 45,702,455 (GRCm38)	T103A	probably damaging	Het
Cecr2	T	A	6: 120,762,430 (GRCm38)	S1373T	probably benign	Het
Cenpm	A	G	15: 82,234,433 (GRCm38)	V160A	possibly damaging	Het
Chl1	A	T	6: 103,683,207 (GRCm38)	I365F	possibly damaging	Het
Col20a1	C	T	2: 181,009,407 (GRCm38)	Q1089*	probably null	Het
Csf1r	A	T	18: 61,105,986 (GRCm38)	T13S	probably benign	Het
Fam13a	T	C	6: 58,956,858 (GRCm38)	E249G	probably damaging	Het
Fgd6	G	A	10: 94,044,456 (GRCm38)	V391I	probably benign	Het
Fhdc1	G	A	3: 84,455,061 (GRCm38)		probably benign	Het
Fn3krp	T	C	11: 121,429,630 (GRCm38)	I267T	probably damaging	Het
Fras1	A	T	5: 96,743,071 (GRCm38)	I2820F	probably benign	Het
Fyb2	A	G	4: 105,015,742 (GRCm38)	I771V	probably damaging	Het
Glis1	A	G	4: 107,615,051 (GRCm38)	Y275C	probably damaging	Het
Hdgf	A	G	3: 87,913,428 (GRCm38)	T62A	possibly damaging	Het
Hsd17b3	C	T	13: 64,063,087 (GRCm38)		probably null	Het
Iqgap1	T	A	7: 80,713,842 (GRCm38)	Y1655F	probably benign	Het
Izumo1	A	G	7: 45,625,164 (GRCm38)	D181G	probably damaging	Het
Lrp2	T	C	2: 69,438,478 (GRCm38)		probably benign	Het
Mark1	T	C	1: 184,919,693 (GRCm38)	N95S	probably damaging	Het
Mbd5	A	G	2: 49,257,751 (GRCm38)	K658E	probably damaging	Het
Mcm6	C	T	1: 128,344,302 (GRCm38)	D453N	probably damaging	Het
Mfsd14a	T	C	3: 116,641,855 (GRCm38)	D187G	probably benign	Het
Mrpl19	G	T	6: 81,961,993 (GRCm38)	S276*	probably null	Het
Ncoa2	G	A	1: 13,190,136 (GRCm38)	T105M	probably damaging	Het
Nop14	A	G	5: 34,650,628 (GRCm38)		probably benign	Het
Olfr1152	G	A	2: 87,868,215 (GRCm38)	A75T	possibly damaging	Het
Olfr170	T	C	16: 19,606,591 (GRCm38)	T26A	probably benign	Het
Otud7b	G	A	3: 96,155,478 (GRCm38)	S678N	probably benign	Het
Pcdhb6	G	A	18: 37,336,152 (GRCm38)	V25M	probably damaging	Het
Prpf39	G	T	12: 65,043,302 (GRCm38)	G5*	probably null	Het
Serpinb9d	T	C	13: 33,202,912 (GRCm38)	V321A	probably damaging	Het
Sh2b1	A	G	7: 126,468,530 (GRCm38)	S613P	possibly damaging	Het
Snx30	T	C	4: 59,857,452 (GRCm38)	I55T	probably benign	Het
Spata13	T	C	14: 60,691,614 (GRCm38)	I207T	possibly damaging	Het
Suco	T	C	1: 161,857,337 (GRCm38)		probably benign	Het
Svs2	A	G	2: 164,237,112 (GRCm38)	S292P	possibly damaging	Het
Tcam1	A	G	11: 106,285,386 (GRCm38)	I313V	probably benign	Het
Tmem45a	A	T	16: 56,811,573 (GRCm38)	Y227*	probably null	Het
Tnfsf15	A	G	4: 63,730,052 (GRCm38)		probably benign	Het
Ttc26	C	T	6: 38,425,231 (GRCm38)	P553S	probably benign	Het
Vmn2r4	C	A	3: 64,389,168 (GRCm38)	R732L	possibly damaging	Het
Wdr7	C	T	18: 63,760,601 (GRCm38)	T602I	probably benign	Het

Other mutations in Olfr1018

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01637:Olfr1018	APN	2	85,822,988 (GRCm38)	missense	probably benign	0.00
IGL02795:Olfr1018	APN	2	85,823,512 (GRCm38)	nonsense	probably null
IGL03329:Olfr1018	APN	2	85,823,385 (GRCm38)	missense	probably benign	0.02
IGL03400:Olfr1018	APN	2	85,823,750 (GRCm38)	missense	probably damaging	1.00
G1patch:Olfr1018	UTSW	2	85,823,790 (GRCm38)	missense	probably damaging	0.97
IGL02796:Olfr1018	UTSW	2	85,823,589 (GRCm38)	missense	probably benign	0.00
R5322:Olfr1018	UTSW	2	85,823,187 (GRCm38)	missense	probably damaging	0.99
R5597:Olfr1018	UTSW	2	85,823,460 (GRCm38)	missense	probably damaging	0.96
R6521:Olfr1018	UTSW	2	85,823,450 (GRCm38)	missense	probably benign	0.01
R6725:Olfr1018	UTSW	2	85,823,790 (GRCm38)	missense	probably damaging	0.97
R7068:Olfr1018	UTSW	2	85,823,052 (GRCm38)	missense	probably benign	0.00
R7105:Olfr1018	UTSW	2	85,823,880 (GRCm38)	missense	probably benign	0.22
R8011:Olfr1018	UTSW	2	85,823,613 (GRCm38)	missense	possibly damaging	0.90
R8294:Olfr1018	UTSW	2	85,823,187 (GRCm38)	missense	probably damaging	0.99
R9160:Olfr1018	UTSW	2	85,822,974 (GRCm38)	start codon destroyed	probably null	0.37
Z1176:Olfr1018	UTSW	2	85,823,021 (GRCm38)	missense	probably damaging	1.00

Posted On

2016-08-02