Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03190:Il1f9'

412613

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Il1f9

Ensembl Gene

ENSMUSG00000044103

Gene Name

interleukin 1 family, member 9

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL03190

Quality Score

Status

Chromosome

Chromosomal Location

24186476-24193568 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

C to A at 24187260 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Stop codon at position 28 (S28*)

Ref Sequence

ENSEMBL: ENSMUSP00000053391 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057567]

Predicted Effect

probably null
Transcript: ENSMUST00000057567
AA Change: S28*

SMART Domains

Protein: ENSMUSP00000053391
Gene: ENSMUSG00000044103
AA Change: S28*

Domain	Start	End	E-Value	Type
IL1	43	190	7.91e-5	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the interleukin 1 cytokine family. The activity of this cytokine is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta). Interferon-gamma, tumor necrosis factor-alpha and interleukin 1, beta (IL1B) are reported to stimulate the expression of this cytokine in keratinocytes. The expression of this cytokine in keratinocytes can also be induced by a contact hypersensitivity reaction or herpes simplex virus infection. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adcy4	A	T	14: 55,779,053	C314S	probably damaging	Het
Agr2	T	A	12: 35,998,635	I128N	probably damaging	Het
Akr1c6	T	C	13: 4,446,413	I91T	possibly damaging	Het
Ankrd45	A	G	1: 161,163,339	I221V	probably benign	Het
Armc3	A	T	2: 19,288,950	L517F	probably damaging	Het
Atp13a3	A	T	16: 30,322,948	M1129K	probably benign	Het
Atp6v0a4	T	A	6: 38,054,556	Q670L	probably benign	Het
Bank1	T	C	3: 136,100,424	Y483C	probably damaging	Het
Bcan	A	T	3: 87,993,050		probably benign	Het
Bcl11a	G	A	11: 24,158,333	E104K	probably benign	Het
Clasp2	C	T	9: 113,844,140	Q368*	probably null	Het
Clcn1	T	A	6: 42,290,103	Y71N	probably benign	Het
Cul2	C	T	18: 3,429,634	T498I	possibly damaging	Het
Fam205a1	C	A	4: 42,848,362	G1265C	probably benign	Het
Fat4	A	G	3: 38,981,241	D3014G	probably damaging	Het
Flnc	T	C	6: 29,445,637		probably benign	Het
Itgb3bp	A	G	4: 99,789,686		probably benign	Het
Itm2b	G	A	14: 73,365,789	P120L	probably damaging	Het
Klk1b26	T	C	7: 44,012,727	F3S	possibly damaging	Het
Lin52	T	C	12: 84,457,958	V39A	probably damaging	Het
Magt1	A	C	X: 105,989,016	N242K	probably benign	Het
Nos3	A	G	5: 24,383,629	M1118V	probably damaging	Het
Olfr341	A	T	2: 36,479,722	M136K	probably damaging	Het
Olfr420	T	C	1: 174,159,544	V257A	probably damaging	Het
Paqr5	A	C	9: 61,972,802	L56R	probably damaging	Het
Pcdhb16	T	C	18: 37,479,343	F452S	probably damaging	Het
Prdm5	T	A	6: 65,856,132		probably benign	Het
Rps6ka5	A	G	12: 100,558,648		probably benign	Het
Slc22a5	A	G	11: 53,875,014	F249L	probably benign	Het
Ttll2	T	C	17: 7,351,380	K383E	probably benign	Het
Ube2o	G	A	11: 116,545,128	P353L	probably damaging	Het
Vmn1r63	T	C	7: 5,803,111	D174G	probably benign	Het
Vmn2r82	A	G	10: 79,356,809		probably null	Het
Xpnpep2	T	A	X: 48,118,328		probably benign	Het
Zfp352	T	A	4: 90,223,757	S45T	possibly damaging	Het
Zfp811	A	G	17: 32,798,881		probably benign	Het
Zfyve19	G	A	2: 119,216,236	A304T	probably damaging	Het

Other mutations in Il1f9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02027:Il1f9	APN	2	24192785	missense	probably benign	0.06
IGL03047:Il1f9	UTSW	2	24192707	missense	probably damaging	1.00
R2384:Il1f9	UTSW	2	24192648	missense	probably benign	0.43
R5158:Il1f9	UTSW	2	24192786	missense	probably damaging	0.99
R5916:Il1f9	UTSW	2	24192794	makesense	probably null
R6875:Il1f9	UTSW	2	24188621	critical splice acceptor site	probably null
R8187:Il1f9	UTSW	2	24192605	missense	probably damaging	1.00
R8357:Il1f9	UTSW	2	24188649	missense	probably benign	0.45
R8457:Il1f9	UTSW	2	24188649	missense	probably benign	0.45

Posted On

2016-08-02