Incidental Mutation 'IGL03191:Zfp641'
| ID |
412659 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp641
|
| Ensembl Gene |
ENSMUSG00000022987 |
| Gene Name |
zinc finger protein 641 |
| Synonyms |
9930016F01Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL03191
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
15 |
| Chromosomal Location |
98183466-98194042 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 98186568 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 352
(V352M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133212
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023722]
[ENSMUST00000169721]
|
| AlphaFold |
Q8BZ34 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000023722
AA Change: V338M
PolyPhen 2
Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000023722
Gene: ENSMUSG00000022987
AA Change: V338M
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
91 |
142 |
2.16e-10 |
SMART |
|
ZnF_C2H2
|
236 |
258 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
264 |
286 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
292 |
314 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
342 |
364 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
370 |
392 |
3.83e-2 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169721
AA Change: V352M
PolyPhen 2
Score 0.978 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000133212
Gene: ENSMUSG00000022987
AA Change: V352M
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
83 |
89 |
N/A |
INTRINSIC |
|
KRAB
|
95 |
156 |
2.56e-21 |
SMART |
|
ZnF_C2H2
|
250 |
272 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
278 |
300 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
306 |
328 |
1.33e-1 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
8.94e-3 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
3.83e-2 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aox1 |
A |
G |
1: 58,398,228 (GRCm39) |
D1323G |
probably null |
Het |
| Asxl2 |
A |
G |
12: 3,550,094 (GRCm39) |
D612G |
probably damaging |
Het |
| Cacna1c |
A |
T |
6: 118,718,864 (GRCm39) |
F395L |
probably damaging |
Het |
| Cct8 |
A |
G |
16: 87,283,198 (GRCm39) |
S380P |
probably damaging |
Het |
| Cltb |
T |
C |
13: 54,746,883 (GRCm39) |
E31G |
probably damaging |
Het |
| Cobl |
T |
C |
11: 12,203,364 (GRCm39) |
M1031V |
probably benign |
Het |
| Colgalt1 |
C |
A |
8: 72,075,731 (GRCm39) |
|
probably null |
Het |
| Dcstamp |
A |
G |
15: 39,617,620 (GRCm39) |
I10V |
probably benign |
Het |
| Diaph3 |
T |
C |
14: 87,310,738 (GRCm39) |
I138V |
possibly damaging |
Het |
| Dnah8 |
T |
C |
17: 30,945,804 (GRCm39) |
V1827A |
probably damaging |
Het |
| Dpf1 |
T |
A |
7: 29,015,986 (GRCm39) |
|
probably benign |
Het |
| Dscam |
A |
T |
16: 96,621,969 (GRCm39) |
L494Q |
probably benign |
Het |
| Eif2ak4 |
C |
T |
2: 118,252,693 (GRCm39) |
H422Y |
probably damaging |
Het |
| Galnt10 |
T |
C |
11: 57,662,326 (GRCm39) |
V324A |
probably damaging |
Het |
| Hcfc1 |
T |
C |
X: 72,999,220 (GRCm39) |
I309V |
probably benign |
Het |
| Il24 |
T |
C |
1: 130,812,584 (GRCm39) |
T96A |
probably benign |
Het |
| Itga2 |
T |
C |
13: 114,973,020 (GRCm39) |
|
probably benign |
Het |
| Lrrc32 |
A |
G |
7: 98,147,454 (GRCm39) |
H78R |
possibly damaging |
Het |
| Lrrk1 |
T |
C |
7: 65,909,707 (GRCm39) |
E2001G |
probably damaging |
Het |
| Lztr1 |
T |
A |
16: 17,336,392 (GRCm39) |
M199K |
probably damaging |
Het |
| Mcm8 |
A |
G |
2: 132,663,362 (GRCm39) |
Y160C |
possibly damaging |
Het |
| Msh4 |
G |
A |
3: 153,575,245 (GRCm39) |
T710M |
probably damaging |
Het |
| Pate8 |
T |
C |
9: 36,492,698 (GRCm39) |
D69G |
probably benign |
Het |
| Pilrb1 |
A |
T |
5: 137,853,227 (GRCm39) |
L192Q |
probably damaging |
Het |
| Pim1 |
T |
A |
17: 29,712,693 (GRCm39) |
|
probably benign |
Het |
| Slc12a1 |
A |
T |
2: 125,048,009 (GRCm39) |
Q817L |
possibly damaging |
Het |
| Trip11 |
T |
C |
12: 101,865,184 (GRCm39) |
D163G |
probably damaging |
Het |
| Tsc2 |
A |
T |
17: 24,847,028 (GRCm39) |
V179E |
probably damaging |
Het |
|
| Other mutations in Zfp641 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01639:Zfp641
|
APN |
15 |
98,189,066 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03092:Zfp641
|
APN |
15 |
98,188,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0079:Zfp641
|
UTSW |
15 |
98,186,970 (GRCm39) |
missense |
probably benign |
0.28 |
|
R0243:Zfp641
|
UTSW |
15 |
98,187,008 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R0487:Zfp641
|
UTSW |
15 |
98,187,060 (GRCm39) |
missense |
probably benign |
|
|
R2092:Zfp641
|
UTSW |
15 |
98,191,593 (GRCm39) |
missense |
probably benign |
|
|
R3415:Zfp641
|
UTSW |
15 |
98,188,421 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4834:Zfp641
|
UTSW |
15 |
98,191,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4851:Zfp641
|
UTSW |
15 |
98,186,598 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5776:Zfp641
|
UTSW |
15 |
98,186,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6057:Zfp641
|
UTSW |
15 |
98,190,816 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6896:Zfp641
|
UTSW |
15 |
98,191,684 (GRCm39) |
start codon destroyed |
probably benign |
0.06 |
|
R6958:Zfp641
|
UTSW |
15 |
98,190,832 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6969:Zfp641
|
UTSW |
15 |
98,188,448 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8117:Zfp641
|
UTSW |
15 |
98,186,856 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Zfp641
|
UTSW |
15 |
98,188,464 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9130:Zfp641
|
UTSW |
15 |
98,186,732 (GRCm39) |
missense |
probably benign |
0.12 |
|
Z1177:Zfp641
|
UTSW |
15 |
98,186,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation