Incidental Mutation 'IGL03195:Olfr698'
ID412764
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr698
Ensembl Gene ENSMUSG00000059087
Gene Nameolfactory receptor 698
SynonymsMOR283-3, GA_x6K02T2PBJ9-9130754-9129519
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.078) question?
Stock #IGL03195
Quality Score
Status
Chromosome7
Chromosomal Location106749889-106755397 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 106752773 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 205 (I205T)
Ref Sequence ENSEMBL: ENSMUSP00000149305 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074981] [ENSMUST00000214306] [ENSMUST00000216255]
Predicted Effect probably benign
Transcript: ENSMUST00000074981
AA Change: I205T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000074509
Gene: ENSMUSG00000059087
AA Change: I205T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 9.4e-50 PFAM
Pfam:7TM_GPCR_Srsx 35 305 9.8e-8 PFAM
Pfam:7tm_1 41 290 4.1e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214306
AA Change: I205T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215892
Predicted Effect probably benign
Transcript: ENSMUST00000216255
AA Change: I205T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1b A G 5: 8,853,607 D1086G possibly damaging Het
Ahcyl2 T C 6: 29,906,769 probably benign Het
Ankrd42 T A 7: 92,591,858 Q431L probably benign Het
Arhgap12 A T 18: 6,031,766 F592I probably damaging Het
Arhgef28 A G 13: 97,951,563 probably null Het
Boc A G 16: 44,492,821 F560S probably damaging Het
Ccdc81 A T 7: 89,896,708 V96E probably benign Het
Cep162 C T 9: 87,225,786 S517N probably benign Het
Cntnap5a A G 1: 116,157,448 N372S probably benign Het
Dnah7a G A 1: 53,419,607 R3791C probably damaging Het
Fdxr T C 11: 115,276,092 Q57R probably benign Het
G3bp2 A G 5: 92,068,508 probably benign Het
Gm595 T A X: 48,872,948 Q296L possibly damaging Het
Hmcn1 G A 1: 150,802,909 T487I probably benign Het
Kpna7 A T 5: 144,997,037 I282N probably damaging Het
Lif A T 11: 4,269,201 Y160F probably damaging Het
Lrp1b A T 2: 41,471,122 D556E possibly damaging Het
Myom2 G T 8: 15,111,844 E954* probably null Het
Nr6a1 A T 2: 38,742,936 I171N probably damaging Het
Nup210 C A 6: 91,015,850 R1059L probably benign Het
Olfr1109 A T 2: 87,092,569 V276E probably damaging Het
Olfr225 G A 11: 59,613,803 V280M probably damaging Het
Olfr743 A G 14: 50,533,420 T3A probably benign Het
Olfr987 A T 2: 85,331,520 I126N probably damaging Het
Ostm1 T C 10: 42,698,217 V302A probably damaging Het
Oxct1 A G 15: 4,101,189 M388V possibly damaging Het
Ppp6r2 G A 15: 89,268,555 V300I possibly damaging Het
Prmt1 T C 7: 44,977,571 Y205C probably damaging Het
Slc45a4 A C 15: 73,584,423 V636G possibly damaging Het
Spata18 T A 5: 73,671,248 L270Q probably damaging Het
Stard9 G A 2: 120,705,802 D4151N probably damaging Het
Thsd7b G A 1: 129,628,909 C334Y probably damaging Het
Tmtc3 C T 10: 100,459,034 V406M probably benign Het
Trpc5 T A X: 144,382,728 M900L probably benign Het
Ttc9c T C 19: 8,815,980 K99E probably benign Het
Vmn1r73 A G 7: 11,757,080 E275G probably damaging Het
Other mutations in Olfr698
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01373:Olfr698 APN 7 106752446 utr 3 prime probably benign
IGL01901:Olfr698 APN 7 106752545 missense possibly damaging 0.52
IGL01912:Olfr698 APN 7 106752992 missense probably damaging 1.00
IGL01998:Olfr698 APN 7 106752551 missense possibly damaging 0.63
IGL02640:Olfr698 APN 7 106753352 missense probably damaging 1.00
R0255:Olfr698 UTSW 7 106752989 missense probably benign 0.19
R1104:Olfr698 UTSW 7 106752782 missense probably benign 0.37
R1796:Olfr698 UTSW 7 106752549 missense probably benign 0.02
R1909:Olfr698 UTSW 7 106752995 missense probably benign 0.21
R4133:Olfr698 UTSW 7 106753079 missense probably damaging 0.98
R5194:Olfr698 UTSW 7 106753219 missense probably benign 0.15
R5389:Olfr698 UTSW 7 106753083 missense probably damaging 0.99
R5426:Olfr698 UTSW 7 106752566 missense probably benign
R6162:Olfr698 UTSW 7 106753020 missense probably damaging 1.00
R6463:Olfr698 UTSW 7 106752801 missense probably benign 0.23
R6643:Olfr698 UTSW 7 106752569 missense probably benign 0.41
R6831:Olfr698 UTSW 7 106752571 missense probably damaging 0.99
R6972:Olfr698 UTSW 7 106752699 missense possibly damaging 0.60
R7392:Olfr698 UTSW 7 106753382 missense possibly damaging 0.69
R7717:Olfr698 UTSW 7 106752636 missense possibly damaging 0.58
R7852:Olfr698 UTSW 7 106752638 missense probably damaging 0.98
R8073:Olfr698 UTSW 7 106752801 nonsense probably null
R8245:Olfr698 UTSW 7 106753167 missense probably benign 0.03
Posted On2016-08-02