Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03195:Olfr225'

412779

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr225

Ensembl Gene

ENSMUSG00000044061

Gene Name

olfactory receptor 225

Synonyms

GA_x6K02T0073K-490-1545, MOR256-51

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL03195

Quality Score

Status

Chromosome

Chromosomal Location

59612966-59613882 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 59613803 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 280 (V280M)

Ref Sequence

ENSEMBL: ENSMUSP00000051482 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055276] [ENSMUST00000213169]

Predicted Effect

probably damaging
Transcript: ENSMUST00000055276
AA Change: V280M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000051482
Gene: ENSMUSG00000044061
AA Change: V280M

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	307	6.6e-47	PFAM
Pfam:7tm_1	40	289	4.3e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213169
AA Change: V280M

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1b	A	G	5: 8,853,607	D1086G	possibly damaging	Het
Ahcyl2	T	C	6: 29,906,769		probably benign	Het
Ankrd42	T	A	7: 92,591,858	Q431L	probably benign	Het
Arhgap12	A	T	18: 6,031,766	F592I	probably damaging	Het
Arhgef28	A	G	13: 97,951,563		probably null	Het
Boc	A	G	16: 44,492,821	F560S	probably damaging	Het
Ccdc81	A	T	7: 89,896,708	V96E	probably benign	Het
Cep162	C	T	9: 87,225,786	S517N	probably benign	Het
Cntnap5a	A	G	1: 116,157,448	N372S	probably benign	Het
Dnah7a	G	A	1: 53,419,607	R3791C	probably damaging	Het
Fdxr	T	C	11: 115,276,092	Q57R	probably benign	Het
G3bp2	A	G	5: 92,068,508		probably benign	Het
Gm595	T	A	X: 48,872,948	Q296L	possibly damaging	Het
Hmcn1	G	A	1: 150,802,909	T487I	probably benign	Het
Kpna7	A	T	5: 144,997,037	I282N	probably damaging	Het
Lif	A	T	11: 4,269,201	Y160F	probably damaging	Het
Lrp1b	A	T	2: 41,471,122	D556E	possibly damaging	Het
Myom2	G	T	8: 15,111,844	E954*	probably null	Het
Nr6a1	A	T	2: 38,742,936	I171N	probably damaging	Het
Nup210	C	A	6: 91,015,850	R1059L	probably benign	Het
Olfr1109	A	T	2: 87,092,569	V276E	probably damaging	Het
Olfr698	A	G	7: 106,752,773	I205T	probably benign	Het
Olfr743	A	G	14: 50,533,420	T3A	probably benign	Het
Olfr987	A	T	2: 85,331,520	I126N	probably damaging	Het
Ostm1	T	C	10: 42,698,217	V302A	probably damaging	Het
Oxct1	A	G	15: 4,101,189	M388V	possibly damaging	Het
Ppp6r2	G	A	15: 89,268,555	V300I	possibly damaging	Het
Prmt1	T	C	7: 44,977,571	Y205C	probably damaging	Het
Slc45a4	A	C	15: 73,584,423	V636G	possibly damaging	Het
Spata18	T	A	5: 73,671,248	L270Q	probably damaging	Het
Stard9	G	A	2: 120,705,802	D4151N	probably damaging	Het
Thsd7b	G	A	1: 129,628,909	C334Y	probably damaging	Het
Tmtc3	C	T	10: 100,459,034	V406M	probably benign	Het
Trpc5	T	A	X: 144,382,728	M900L	probably benign	Het
Ttc9c	T	C	19: 8,815,980	K99E	probably benign	Het
Vmn1r73	A	G	7: 11,757,080	E275G	probably damaging	Het

Other mutations in Olfr225

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Olfr225	APN	11	59613321	missense	possibly damaging	0.86
IGL01835:Olfr225	APN	11	59613339	missense	probably damaging	0.99
IGL02006:Olfr225	APN	11	59613159	missense	probably damaging	1.00
R0148:Olfr225	UTSW	11	59613494	missense	probably damaging	1.00
R0831:Olfr225	UTSW	11	59613654	missense	possibly damaging	0.70
R1924:Olfr225	UTSW	11	59613123	missense	possibly damaging	0.58
R2184:Olfr225	UTSW	11	59613138	missense	probably damaging	1.00
R5772:Olfr225	UTSW	11	59613886	missense	probably benign
R6986:Olfr225	UTSW	11	59614098	missense	possibly damaging	0.53
R7405:Olfr225	UTSW	11	59614073	missense	possibly damaging	0.53
R7755:Olfr225	UTSW	11	59613641	missense	probably damaging	0.97
R7851:Olfr225	UTSW	11	59613963	missense	probably benign	0.33
Z1177:Olfr225	UTSW	11	59613572	missense	probably damaging	1.00

Posted On

2016-08-02