Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03195:Or2w25'

412779

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or2w25

Ensembl Gene

ENSMUSG00000044061

Gene Name

olfactory receptor family 2 subfamily W member 25

Synonyms

MOR256-51, GA_x6K02T0073K-490-1545, Olfr225

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

IGL03195

Quality Score

Status

Chromosome

Chromosomal Location

59503792-59505051 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 59504629 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 280 (V280M)

Ref Sequence

ENSEMBL: ENSMUSP00000051482 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055276] [ENSMUST00000213169]

AlphaFold

E9PWF9

Predicted Effect

probably damaging
Transcript: ENSMUST00000055276
AA Change: V280M

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000051482
Gene: ENSMUSG00000044061
AA Change: V280M

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	307	6.6e-47	PFAM
Pfam:7tm_1	40	289	4.3e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213169
AA Change: V280M

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1b	A	G	5: 8,903,607 (GRCm39)	D1086G	possibly damaging	Het
Ahcyl2	T	C	6: 29,906,768 (GRCm39)		probably benign	Het
Ankrd42	T	A	7: 92,241,066 (GRCm39)	Q431L	probably benign	Het
Arhgap12	A	T	18: 6,031,766 (GRCm39)	F592I	probably damaging	Het
Arhgef28	A	G	13: 98,088,071 (GRCm39)		probably null	Het
Boc	A	G	16: 44,313,184 (GRCm39)	F560S	probably damaging	Het
Ccdc81	A	T	7: 89,545,916 (GRCm39)	V96E	probably benign	Het
Cep162	C	T	9: 87,107,839 (GRCm39)	S517N	probably benign	Het
Cntnap5a	A	G	1: 116,085,178 (GRCm39)	N372S	probably benign	Het
Dnah7a	G	A	1: 53,458,766 (GRCm39)	R3791C	probably damaging	Het
Fdxr	T	C	11: 115,166,918 (GRCm39)	Q57R	probably benign	Het
Fsip2l	T	A	X: 47,961,825 (GRCm39)	Q296L	possibly damaging	Het
G3bp2	A	G	5: 92,216,367 (GRCm39)		probably benign	Het
Hmcn1	G	A	1: 150,678,660 (GRCm39)	T487I	probably benign	Het
Kpna7	A	T	5: 144,933,847 (GRCm39)	I282N	probably damaging	Het
Lif	A	T	11: 4,219,201 (GRCm39)	Y160F	probably damaging	Het
Lrp1b	A	T	2: 41,361,134 (GRCm39)	D556E	possibly damaging	Het
Myom2	G	T	8: 15,161,844 (GRCm39)	E954*	probably null	Het
Nr6a1	A	T	2: 38,632,948 (GRCm39)	I171N	probably damaging	Het
Nup210	C	A	6: 90,992,832 (GRCm39)	R1059L	probably benign	Het
Or11g27	A	G	14: 50,770,877 (GRCm39)	T3A	probably benign	Het
Or2ag16	A	G	7: 106,351,980 (GRCm39)	I205T	probably benign	Het
Or5ak4	A	T	2: 85,161,864 (GRCm39)	I126N	probably damaging	Het
Or5aq6	A	T	2: 86,922,913 (GRCm39)	V276E	probably damaging	Het
Ostm1	T	C	10: 42,574,213 (GRCm39)	V302A	probably damaging	Het
Oxct1	A	G	15: 4,130,671 (GRCm39)	M388V	possibly damaging	Het
Ppp6r2	G	A	15: 89,152,758 (GRCm39)	V300I	possibly damaging	Het
Prmt1	T	C	7: 44,626,995 (GRCm39)	Y205C	probably damaging	Het
Slc45a4	A	C	15: 73,456,272 (GRCm39)	V636G	possibly damaging	Het
Spata18	T	A	5: 73,828,591 (GRCm39)	L270Q	probably damaging	Het
Stard9	G	A	2: 120,536,283 (GRCm39)	D4151N	probably damaging	Het
Thsd7b	G	A	1: 129,556,646 (GRCm39)	C334Y	probably damaging	Het
Tmtc3	C	T	10: 100,294,896 (GRCm39)	V406M	probably benign	Het
Trpc5	T	A	X: 143,165,724 (GRCm39)	M900L	probably benign	Het
Ttc9c	T	C	19: 8,793,344 (GRCm39)	K99E	probably benign	Het
Vmn1r73	A	G	7: 11,491,007 (GRCm39)	E275G	probably damaging	Het

Other mutations in Or2w25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00090:Or2w25	APN	11	59,504,147 (GRCm39)	missense	possibly damaging	0.86
IGL01835:Or2w25	APN	11	59,504,165 (GRCm39)	missense	probably damaging	0.99
IGL02006:Or2w25	APN	11	59,503,985 (GRCm39)	missense	probably damaging	1.00
R0148:Or2w25	UTSW	11	59,504,320 (GRCm39)	missense	probably damaging	1.00
R0831:Or2w25	UTSW	11	59,504,480 (GRCm39)	missense	possibly damaging	0.70
R1924:Or2w25	UTSW	11	59,503,949 (GRCm39)	missense	possibly damaging	0.58
R2184:Or2w25	UTSW	11	59,503,964 (GRCm39)	missense	probably damaging	1.00
R5772:Or2w25	UTSW	11	59,504,712 (GRCm39)	missense	probably benign
R6986:Or2w25	UTSW	11	59,504,924 (GRCm39)	missense	possibly damaging	0.53
R7405:Or2w25	UTSW	11	59,504,899 (GRCm39)	missense	possibly damaging	0.53
R7755:Or2w25	UTSW	11	59,504,467 (GRCm39)	missense	probably damaging	0.97
R7851:Or2w25	UTSW	11	59,504,789 (GRCm39)	missense	probably benign	0.33
R9437:Or2w25	UTSW	11	59,504,195 (GRCm39)	missense	possibly damaging	0.92
R9545:Or2w25	UTSW	11	59,504,275 (GRCm39)	missense	probably benign	0.27
R9562:Or2w25	UTSW	11	59,504,580 (GRCm39)	missense	probably damaging	1.00
R9565:Or2w25	UTSW	11	59,504,339 (GRCm39)	missense	probably damaging	1.00
Z1177:Or2w25	UTSW	11	59,504,398 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02