Incidental Mutation 'IGL03197:Mill1'
ID412865
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mill1
Ensembl Gene ENSMUSG00000054005
Gene NameMHC I like leukocyte 1
Synonyms5530400I18Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.145) question?
Stock #IGL03197
Quality Score
Status
Chromosome7
Chromosomal Location18245347-18266092 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 18264665 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 267 (T267A)
Ref Sequence ENSEMBL: ENSMUSP00000069083 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000066780]
Predicted Effect probably benign
Transcript: ENSMUST00000066780
AA Change: T267A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000069083
Gene: ENSMUSG00000054005
AA Change: T267A

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
Pfam:MHC_I 60 236 3.8e-33 PFAM
IGc1 255 327 3.53e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030J22Rik A G 8: 116,971,802 W189R probably damaging Het
Abcb7 A T X: 104,284,191 M704K possibly damaging Het
Anp32e A G 3: 95,937,052 D71G probably damaging Het
Asphd1 T C 7: 126,946,126 D353G probably damaging Het
Baz2b T C 2: 59,901,554 K2047E possibly damaging Het
Cyp2c39 G T 19: 39,566,917 V394F probably damaging Het
Ddx43 G A 9: 78,418,120 M482I probably benign Het
Dnah2 A T 11: 69,459,263 V2348E probably damaging Het
Fam135a A G 1: 24,044,182 F304L probably damaging Het
Gabra3 A G X: 72,540,128 I66T possibly damaging Het
Gm5861 T G 5: 11,183,113 N14K probably damaging Het
Gm8857 T A 5: 10,950,534 probably benign Het
Irf4 A T 13: 30,763,520 probably benign Het
Kif11 A G 19: 37,407,027 D578G probably benign Het
Lrig1 A G 6: 94,606,118 S1006P probably benign Het
Mfsd14a A C 3: 116,636,363 S307A probably benign Het
Nfyc C A 4: 120,773,761 D62Y probably damaging Het
Nin T C 12: 70,026,810 T1190A probably benign Het
Nupl2 T C 5: 24,167,465 S84P probably damaging Het
Ociad1 T C 5: 73,294,332 S15P probably benign Het
Olfr1199 A T 2: 88,756,201 I158K probably damaging Het
Olfr822 A T 10: 130,074,679 I90F probably damaging Het
Olfr843 A G 9: 19,248,802 I199T probably benign Het
Pcdhb11 T A 18: 37,422,424 L269* probably null Het
Pigo A C 4: 43,022,103 M352R possibly damaging Het
Plch1 T C 3: 63,753,170 M343V probably damaging Het
Podnl1 G A 8: 84,132,189 V548I probably benign Het
Prkag1 A G 15: 98,815,177 probably benign Het
Rasa4 A G 5: 136,102,012 K379R probably damaging Het
Rraga G A 4: 86,576,276 A120T probably damaging Het
Serpina3a C T 12: 104,116,241 A91V probably damaging Het
Sik2 T C 9: 50,895,773 E779G probably damaging Het
Slc15a3 T G 19: 10,855,079 probably null Het
Smc1b C T 15: 85,070,863 D1063N possibly damaging Het
Srsf12 G A 4: 33,231,040 G183E probably damaging Het
Taf8 A G 17: 47,498,202 S112P probably benign Het
Trhde A G 10: 114,413,308 L851P probably benign Het
Wapl G T 14: 34,745,631 V1182F possibly damaging Het
Zfp326 A G 5: 105,891,193 I231V probably benign Het
Other mutations in Mill1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Mill1 APN 7 18264641 missense possibly damaging 0.91
IGL01313:Mill1 APN 7 18264633 missense possibly damaging 0.82
IGL01417:Mill1 APN 7 18264783 missense probably benign 0.18
IGL01997:Mill1 APN 7 18255889 missense probably damaging 1.00
IGL02282:Mill1 APN 7 18263204 critical splice donor site probably null
IGL03126:Mill1 APN 7 18255907 missense probably benign 0.33
R0513:Mill1 UTSW 7 18264877 nonsense probably null
R0515:Mill1 UTSW 7 18264873 missense probably benign 0.12
R1460:Mill1 UTSW 7 18262670 missense probably damaging 1.00
R1589:Mill1 UTSW 7 18245647 missense probably benign 0.01
R2192:Mill1 UTSW 7 18264619 nonsense probably null
R3704:Mill1 UTSW 7 18263053 missense possibly damaging 0.91
R3758:Mill1 UTSW 7 18262703 critical splice donor site probably null
R4685:Mill1 UTSW 7 18255928 missense probably damaging 0.98
R4753:Mill1 UTSW 7 18262547 missense probably benign 0.28
R5763:Mill1 UTSW 7 18245662 missense probably benign 0.03
R5938:Mill1 UTSW 7 18262688 missense probably benign 0.00
R7757:Mill1 UTSW 7 18262466 missense probably benign 0.02
R8094:Mill1 UTSW 7 18255910 missense probably benign 0.01
Z1176:Mill1 UTSW 7 18245499 start gained probably benign
Posted On2016-08-02