Incidental Mutation 'IGL03199:Sult2a1'
ID412919
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult2a1
Ensembl Gene ENSMUSG00000078798
Gene Namesulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SynonymsStd, Sth1, mSTa1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL03199
Quality Score
Status
Chromosome7
Chromosomal Location13796246-13837409 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to A at 13832660 bp
ZygosityHeterozygous
Amino Acid Change Glycine to Valine at position 130 (G130V)
Ref Sequence ENSEMBL: ENSMUSP00000104162 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108522]
Predicted Effect probably damaging
Transcript: ENSMUST00000108522
AA Change: G130V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000104162
Gene: ENSMUSG00000078798
AA Change: G130V

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 278 4.6e-83 PFAM
Pfam:Sulfotransfer_3 35 205 5.8e-11 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T C 15: 82,062,355 I151T possibly damaging Het
9030624J02Rik T C 7: 118,766,388 S15P probably benign Het
Alms1 T A 6: 85,622,497 M1904K possibly damaging Het
Chsy3 T A 18: 59,176,401 F242Y probably damaging Het
Cwf19l2 G A 9: 3,477,830 G845D probably damaging Het
Cyfip2 A G 11: 46,276,843 I244T probably benign Het
Dnah10 A T 5: 124,817,697 Q3499L probably benign Het
Fat3 A G 9: 16,377,048 V393A possibly damaging Het
Fcamr T A 1: 130,812,918 V358D probably damaging Het
Fndc3c1 T A X: 106,436,387 K696N possibly damaging Het
Igkv2-112 G A 6: 68,220,016 M12I probably benign Het
Macc1 T C 12: 119,446,421 M308T probably benign Het
Map4k1 A G 7: 28,983,417 E16G probably damaging Het
Myl7 C T 11: 5,898,205 G50R probably damaging Het
Ncapg2 T A 12: 116,419,236 L229H probably damaging Het
Olfr960 A G 9: 39,623,944 I272V probably benign Het
Prkcz A G 4: 155,272,984 F157L possibly damaging Het
Trim27 G A 13: 21,191,251 probably null Het
Trim43b T G 9: 89,089,428 Q225P probably damaging Het
Ugt2b34 A G 5: 86,906,880 L14P unknown Het
Vmn1r209 A T 13: 22,806,050 S157T possibly damaging Het
Vmn2r38 A T 7: 9,075,376 V669D probably damaging Het
Zfp422 T C 6: 116,626,951 Q29R probably benign Het
Zfp623 C T 15: 75,947,270 A25V probably benign Het
Other mutations in Sult2a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Sult2a1 APN 7 13832640 missense probably benign 0.02
IGL00990:Sult2a1 APN 7 13804036 missense probably benign
IGL01322:Sult2a1 APN 7 13832679 nonsense probably null
IGL02558:Sult2a1 APN 7 13832595 missense probably benign 0.03
IGL03033:Sult2a1 APN 7 13832710 splice site probably benign
R1633:Sult2a1 UTSW 7 13801426 missense probably benign 0.01
R1903:Sult2a1 UTSW 7 13835975 missense possibly damaging 0.94
R2295:Sult2a1 UTSW 7 13835959 critical splice donor site probably null
R4207:Sult2a1 UTSW 7 13801547 missense probably benign 0.00
R5444:Sult2a1 UTSW 7 13836019 missense possibly damaging 0.80
R6233:Sult2a1 UTSW 7 13832675 missense probably damaging 1.00
R6317:Sult2a1 UTSW 7 13836020 missense probably benign 0.00
R6853:Sult2a1 UTSW 7 13801487 missense possibly damaging 0.50
R7098:Sult2a1 UTSW 7 13816053 intron probably null
Z1088:Sult2a1 UTSW 7 13801414 missense probably benign
Z1088:Sult2a1 UTSW 7 13801435 missense probably benign 0.00
Z1088:Sult2a1 UTSW 7 13804036 missense probably benign
Posted On2016-08-02