Incidental Mutation 'IGL03199:Zfp623'
ID 412932
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp623
Ensembl Gene ENSMUSG00000050846
Gene Name zinc finger protein 623
Synonyms 2610029D06Rik
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.452) question?
Stock # IGL03199
Quality Score
Status
Chromosome 15
Chromosomal Location 75940952-75949400 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to T at 75947270 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Alanine to Valine at position 25 (A25V)
Ref Sequence ENSEMBL: ENSMUSP00000036049 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037260]
AlphaFold Q9CY99
Predicted Effect probably benign
Transcript: ENSMUST00000037260
AA Change: A25V

PolyPhen 2 Score 0.403 (Sensitivity: 0.89; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000036049
Gene: ENSMUSG00000050846
AA Change: A25V

DomainStartEndE-ValueType
ZnF_C2H2 119 141 5.59e-4 SMART
ZnF_C2H2 147 169 9.96e-1 SMART
ZnF_C2H2 175 197 2.4e-3 SMART
ZnF_C2H2 203 225 6.42e-4 SMART
ZnF_C2H2 231 253 1.3e-4 SMART
ZnF_C2H2 259 281 1.3e-4 SMART
ZnF_C2H2 287 309 1.28e-3 SMART
ZnF_C2H2 315 337 3.21e-4 SMART
ZnF_C2H2 343 365 3.39e-3 SMART
ZnF_C2H2 371 393 4.87e-4 SMART
ZnF_C2H2 399 421 2.53e-2 SMART
ZnF_C2H2 427 449 3.95e-4 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930407I10Rik T C 15: 82,062,355 I151T possibly damaging Het
9030624J02Rik T C 7: 118,766,388 S15P probably benign Het
Alms1 T A 6: 85,622,497 M1904K possibly damaging Het
Chsy3 T A 18: 59,176,401 F242Y probably damaging Het
Cwf19l2 G A 9: 3,477,830 G845D probably damaging Het
Cyfip2 A G 11: 46,276,843 I244T probably benign Het
Dnah10 A T 5: 124,817,697 Q3499L probably benign Het
Fat3 A G 9: 16,377,048 V393A possibly damaging Het
Fcamr T A 1: 130,812,918 V358D probably damaging Het
Fndc3c1 T A X: 106,436,387 K696N possibly damaging Het
Igkv2-112 G A 6: 68,220,016 M12I probably benign Het
Macc1 T C 12: 119,446,421 M308T probably benign Het
Map4k1 A G 7: 28,983,417 E16G probably damaging Het
Myl7 C T 11: 5,898,205 G50R probably damaging Het
Ncapg2 T A 12: 116,419,236 L229H probably damaging Het
Olfr960 A G 9: 39,623,944 I272V probably benign Het
Prkcz A G 4: 155,272,984 F157L possibly damaging Het
Sult2a1 C A 7: 13,832,660 G130V probably damaging Het
Trim27 G A 13: 21,191,251 probably null Het
Trim43b T G 9: 89,089,428 Q225P probably damaging Het
Ugt2b34 A G 5: 86,906,880 L14P unknown Het
Vmn1r209 A T 13: 22,806,050 S157T possibly damaging Het
Vmn2r38 A T 7: 9,075,376 V669D probably damaging Het
Zfp422 T C 6: 116,626,951 Q29R probably benign Het
Other mutations in Zfp623
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00226:Zfp623 APN 15 75948203 missense probably damaging 1.00
IGL01524:Zfp623 APN 15 75947679 missense probably benign
IGL01927:Zfp623 APN 15 75947505 missense possibly damaging 0.57
R0076:Zfp623 UTSW 15 75947209 missense probably benign
R0352:Zfp623 UTSW 15 75948584 missense probably benign 0.00
R0360:Zfp623 UTSW 15 75948661 missense probably benign
R0364:Zfp623 UTSW 15 75948661 missense probably benign
R1783:Zfp623 UTSW 15 75947911 missense probably damaging 0.99
R2219:Zfp623 UTSW 15 75947530 missense possibly damaging 0.90
R5975:Zfp623 UTSW 15 75948163 missense probably benign 0.43
R6161:Zfp623 UTSW 15 75948621 missense probably benign 0.22
R6342:Zfp623 UTSW 15 75947988 nonsense probably null
R6490:Zfp623 UTSW 15 75948459 missense probably damaging 1.00
R6513:Zfp623 UTSW 15 75947468 missense probably benign
R7028:Zfp623 UTSW 15 75948305 missense probably damaging 0.99
R7399:Zfp623 UTSW 15 75947398 missense probably damaging 0.98
R7716:Zfp623 UTSW 15 75948422 missense probably damaging 1.00
R8362:Zfp623 UTSW 15 75947639 missense probably damaging 1.00
R8445:Zfp623 UTSW 15 75947553 nonsense probably null
R9028:Zfp623 UTSW 15 75947500 missense probably damaging 0.97
R9035:Zfp623 UTSW 15 75948313 missense possibly damaging 0.93
R9310:Zfp623 UTSW 15 75948100 missense probably damaging 1.00
Posted On 2016-08-02