Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03200:Taok1'

412946

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Taok1

Ensembl Gene

ENSMUSG00000017291

Gene Name

TAO kinase 1

Synonyms

2810468K05Rik, D130018F14Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.441) question?

Stock #

IGL03200

Quality Score

Status

Chromosome

Chromosomal Location

77419988-77498641 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

G to A at 77466478 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Stop codon at position 124 (Q124*)

Ref Sequence

ENSEMBL: ENSMUSP00000055470 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000017435] [ENSMUST00000058496]

AlphaFold

Q5F2E8

Predicted Effect

probably null
Transcript: ENSMUST00000017435
AA Change: Q124*

SMART Domains

Protein: ENSMUSP00000017435
Gene: ENSMUSG00000017291
AA Change: Q124*

Domain	Start	End	E-Value	Type
S_TKc	28	281	3.26e-87	SMART
low complexity region	327	335	N/A	INTRINSIC
low complexity region	350	370	N/A	INTRINSIC
coiled coil region	458	651	N/A	INTRINSIC
coiled coil region	792	878	N/A	INTRINSIC
low complexity region	914	930	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000058496
AA Change: Q124*

SMART Domains

Protein: ENSMUSP00000055470
Gene: ENSMUSG00000017291
AA Change: Q124*

Domain	Start	End	E-Value	Type
S_TKc	28	281	3.26e-87	SMART
low complexity region	327	335	N/A	INTRINSIC
low complexity region	350	370	N/A	INTRINSIC
coiled coil region	458	651	N/A	INTRINSIC
coiled coil region	792	878	N/A	INTRINSIC
low complexity region	914	930	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 17 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	A	G	12: 118,928,989 (GRCm39)		probably benign	Het
Degs1	A	T	1: 182,107,256 (GRCm39)	M1K	probably null	Het
Eif3e	A	T	15: 43,115,657 (GRCm39)	W370R	probably damaging	Het
H2-M10.6	G	A	17: 37,124,908 (GRCm39)	G275E	probably damaging	Het
Itga8	C	T	2: 12,196,010 (GRCm39)	V647I	probably benign	Het
Kcnip2	T	G	19: 45,782,502 (GRCm39)	K190Q	probably damaging	Het
Mbd1	T	G	18: 74,409,502 (GRCm39)	S251A	probably benign	Het
Mcpt9	T	A	14: 56,264,390 (GRCm39)	H235L	probably benign	Het
Ndst1	A	T	18: 60,832,611 (GRCm39)	I573N	possibly damaging	Het
Ntan1	C	T	16: 13,652,591 (GRCm39)	P229L	probably damaging	Het
Rbl2	T	C	8: 91,823,395 (GRCm39)	I441T	probably benign	Het
Spmap2l	T	A	5: 77,208,711 (GRCm39)	V413D	possibly damaging	Het
Sulf1	C	T	1: 12,856,841 (GRCm39)	R31*	probably null	Het
Tmem140	A	G	6: 34,849,814 (GRCm39)	E110G	possibly damaging	Het
U2surp	G	A	9: 95,373,444 (GRCm39)	R242*	probably null	Het
Ywhag	G	A	5: 135,939,914 (GRCm39)	R227*	probably null	Het
Zfp456	C	T	13: 67,514,596 (GRCm39)	R370H	probably benign	Het

Other mutations in Taok1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01598:Taok1	APN	11	77,462,510 (GRCm39)	missense	probably damaging	1.00
IGL01629:Taok1	APN	11	77,429,030 (GRCm39)	missense	possibly damaging	0.63
IGL02198:Taok1	APN	11	77,466,503 (GRCm39)	splice site	probably benign
IGL02392:Taok1	APN	11	77,440,178 (GRCm39)	missense	probably benign	0.13
IGL02415:Taok1	APN	11	77,431,066 (GRCm39)	unclassified	probably benign
IGL02428:Taok1	APN	11	77,440,103 (GRCm39)	missense	probably benign	0.01
IGL02972:Taok1	APN	11	77,450,584 (GRCm39)	missense	probably benign	0.04
IGL03203:Taok1	APN	11	77,430,911 (GRCm39)	missense	probably damaging	0.96
IGL03292:Taok1	APN	11	77,430,962 (GRCm39)	missense	probably benign	0.07
IGL03351:Taok1	APN	11	77,451,154 (GRCm39)	missense	probably damaging	0.96
R7569_taok1_653	UTSW	11	77,446,440 (GRCm39)	missense	probably benign	0.06
R0070:Taok1	UTSW	11	77,444,543 (GRCm39)	missense	probably benign
R0497:Taok1	UTSW	11	77,464,630 (GRCm39)	missense	probably damaging	0.97
R0535:Taok1	UTSW	11	77,444,530 (GRCm39)	missense	probably benign	0.00
R0558:Taok1	UTSW	11	77,450,670 (GRCm39)	missense	possibly damaging	0.89
R0653:Taok1	UTSW	11	77,469,550 (GRCm39)	critical splice donor site	probably null
R1249:Taok1	UTSW	11	77,462,463 (GRCm39)	missense	probably damaging	1.00
R1424:Taok1	UTSW	11	77,440,190 (GRCm39)	missense	probably benign	0.00
R1597:Taok1	UTSW	11	77,470,626 (GRCm39)	missense	probably benign	0.31
R2112:Taok1	UTSW	11	77,462,472 (GRCm39)	missense	probably benign	0.01
R3716:Taok1	UTSW	11	77,432,636 (GRCm39)	missense	probably benign	0.09
R4013:Taok1	UTSW	11	77,450,659 (GRCm39)	missense	possibly damaging	0.95
R4058:Taok1	UTSW	11	77,440,264 (GRCm39)	missense	probably benign	0.05
R4831:Taok1	UTSW	11	77,444,500 (GRCm39)	missense	probably null	0.34
R5036:Taok1	UTSW	11	77,440,157 (GRCm39)	missense	probably benign	0.01
R5917:Taok1	UTSW	11	77,451,144 (GRCm39)	missense	probably damaging	0.99
R6271:Taok1	UTSW	11	77,464,609 (GRCm39)	missense	probably damaging	1.00
R6286:Taok1	UTSW	11	77,444,599 (GRCm39)	missense	probably benign	0.00
R6860:Taok1	UTSW	11	77,432,627 (GRCm39)	missense	probably benign	0.01
R6933:Taok1	UTSW	11	77,446,479 (GRCm39)	missense	probably benign
R7139:Taok1	UTSW	11	77,462,459 (GRCm39)	missense	probably damaging	1.00
R7143:Taok1	UTSW	11	77,428,814 (GRCm39)	missense	probably benign
R7305:Taok1	UTSW	11	77,432,500 (GRCm39)	nonsense	probably null
R7340:Taok1	UTSW	11	77,470,643 (GRCm39)	missense	possibly damaging	0.89
R7508:Taok1	UTSW	11	77,436,152 (GRCm39)	missense	probably damaging	0.97
R7569:Taok1	UTSW	11	77,446,440 (GRCm39)	missense	probably benign	0.06
R7753:Taok1	UTSW	11	77,428,725 (GRCm39)	missense	probably benign	0.29
R8064:Taok1	UTSW	11	77,440,130 (GRCm39)	nonsense	probably null
R8130:Taok1	UTSW	11	77,470,659 (GRCm39)	missense	possibly damaging	0.84
R8332:Taok1	UTSW	11	77,432,545 (GRCm39)	missense	possibly damaging	0.93
R8768:Taok1	UTSW	11	77,444,712 (GRCm39)	missense	probably damaging	1.00
R8775:Taok1	UTSW	11	77,470,632 (GRCm39)	missense	probably benign	0.42
R8775-TAIL:Taok1	UTSW	11	77,470,632 (GRCm39)	missense	probably benign	0.42
Z1176:Taok1	UTSW	11	77,450,752 (GRCm39)	missense	probably benign	0.00

Posted On

2016-08-02