Incidental Mutation 'IGL03200:Tmem140'
ID 412954
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem140
Ensembl Gene ENSMUSG00000057137
Gene Name transmembrane protein 140
Synonyms 1110007F12Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # IGL03200
Quality Score
Status
Chromosome 6
Chromosomal Location 34840081-34851881 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 34849814 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 110 (E110G)
Ref Sequence ENSEMBL: ENSMUSP00000074482 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055097] [ENSMUST00000074949] [ENSMUST00000115006] [ENSMUST00000115007] [ENSMUST00000118559] [ENSMUST00000202010] [ENSMUST00000202999]
AlphaFold Q8BGY5
Predicted Effect probably benign
Transcript: ENSMUST00000055097
SMART Domains Protein: ENSMUSP00000053349
Gene: ENSMUSG00000046806

DomainStartEndE-ValueType
Pfam:MRI 55 157 2.6e-50 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000074949
AA Change: E110G

PolyPhen 2 Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000074482
Gene: ENSMUSG00000057137
AA Change: E110G

DomainStartEndE-ValueType
Pfam:TM140 6 185 3e-94 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115006
SMART Domains Protein: ENSMUSP00000110658
Gene: ENSMUSG00000046806

DomainStartEndE-ValueType
Pfam:MRI 55 82 3.1e-13 PFAM
Pfam:MRI 97 184 1.2e-30 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115007
SMART Domains Protein: ENSMUSP00000110659
Gene: ENSMUSG00000046806

DomainStartEndE-ValueType
Pfam:MRI 55 157 2.6e-50 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118559
SMART Domains Protein: ENSMUSP00000113335
Gene: ENSMUSG00000046806

DomainStartEndE-ValueType
Pfam:MRI 55 90 4.6e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123019
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140458
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201749
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202764
Predicted Effect probably benign
Transcript: ENSMUST00000202010
Predicted Effect probably benign
Transcript: ENSMUST00000202999
SMART Domains Protein: ENSMUSP00000144113
Gene: ENSMUSG00000057137

DomainStartEndE-ValueType
Pfam:TM140 6 63 4.9e-26 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 A G 12: 118,928,989 (GRCm39) probably benign Het
Degs1 A T 1: 182,107,256 (GRCm39) M1K probably null Het
Eif3e A T 15: 43,115,657 (GRCm39) W370R probably damaging Het
H2-M10.6 G A 17: 37,124,908 (GRCm39) G275E probably damaging Het
Itga8 C T 2: 12,196,010 (GRCm39) V647I probably benign Het
Kcnip2 T G 19: 45,782,502 (GRCm39) K190Q probably damaging Het
Mbd1 T G 18: 74,409,502 (GRCm39) S251A probably benign Het
Mcpt9 T A 14: 56,264,390 (GRCm39) H235L probably benign Het
Ndst1 A T 18: 60,832,611 (GRCm39) I573N possibly damaging Het
Ntan1 C T 16: 13,652,591 (GRCm39) P229L probably damaging Het
Rbl2 T C 8: 91,823,395 (GRCm39) I441T probably benign Het
Spmap2l T A 5: 77,208,711 (GRCm39) V413D possibly damaging Het
Sulf1 C T 1: 12,856,841 (GRCm39) R31* probably null Het
Taok1 G A 11: 77,466,478 (GRCm39) Q124* probably null Het
U2surp G A 9: 95,373,444 (GRCm39) R242* probably null Het
Ywhag G A 5: 135,939,914 (GRCm39) R227* probably null Het
Zfp456 C T 13: 67,514,596 (GRCm39) R370H probably benign Het
Other mutations in Tmem140
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1500:Tmem140 UTSW 6 34,849,660 (GRCm39) missense probably benign 0.00
R1900:Tmem140 UTSW 6 34,849,838 (GRCm39) missense possibly damaging 0.68
R1944:Tmem140 UTSW 6 34,849,747 (GRCm39) missense probably damaging 1.00
R5062:Tmem140 UTSW 6 34,849,897 (GRCm39) missense probably damaging 1.00
R6415:Tmem140 UTSW 6 34,849,658 (GRCm39) missense probably damaging 0.99
R7644:Tmem140 UTSW 6 34,849,708 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02