Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03201:Zfp747'

412970

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp747

Ensembl Gene

ENSMUSG00000054381

Gene Name

zinc finger protein 747

Synonyms

6430604K15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.131) question?

Stock #

IGL03201

Quality Score

Status

Chromosome

Chromosomal Location

126971709-126975222 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 126973180 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 330 (T330I)

Ref Sequence

ENSEMBL: ENSMUSP00000070685 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067425] [ENSMUST00000205832]

AlphaFold

Q8BHM7

Predicted Effect

probably damaging
Transcript: ENSMUST00000067425
AA Change: T330I

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000070685
Gene: ENSMUSG00000054381
AA Change: T330I

Domain	Start	End	E-Value	Type
KRAB	22	82	3.64e-26	SMART
low complexity region	102	115	N/A	INTRINSIC
ZnF_C2H2	152	174	3.63e-3	SMART
ZnF_C2H2	180	202	1.47e-3	SMART
ZnF_C2H2	208	230	6.42e-4	SMART
ZnF_C2H2	236	258	3.63e-3	SMART
ZnF_C2H2	264	286	1.13e-4	SMART
ZnF_C2H2	292	314	1.45e-2	SMART
ZnF_C2H2	320	342	1.5e-4	SMART
ZnF_C2H2	348	371	2.49e-1	SMART
ZnF_C2H2	377	399	3.69e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000205832

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206942

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A4galt	T	C	15: 83,112,468 (GRCm39)	E105G	probably damaging	Het
Apc	A	G	18: 34,445,429 (GRCm39)	D757G	probably damaging	Het
Arpc3	A	T	5: 122,539,781 (GRCm39)	I45F	probably damaging	Het
C3	C	A	17: 57,529,249 (GRCm39)	V597L	probably damaging	Het
Ccdc181	A	G	1: 164,108,213 (GRCm39)	N299D	probably benign	Het
Cdr1	T	A	X: 60,229,154 (GRCm39)	Q4L	unknown	Het
Cep170	G	A	1: 176,564,454 (GRCm39)	S1464F	probably damaging	Het
Cfh	A	G	1: 140,030,557 (GRCm39)	Y826H	probably damaging	Het
Chic2	A	G	5: 75,171,954 (GRCm39)		probably benign	Het
Chrne	T	C	11: 70,509,338 (GRCm39)	H81R	probably benign	Het
Clec4e	A	G	6: 123,260,599 (GRCm39)	I153T	probably benign	Het
Col14a1	A	T	15: 55,272,300 (GRCm39)	D699V	unknown	Het
Cul3	T	G	1: 80,259,144 (GRCm39)	S379R	probably damaging	Het
Cyp3a11	T	A	5: 145,797,189 (GRCm39)	I397F	possibly damaging	Het
Dnah1	T	C	14: 31,022,906 (GRCm39)	K1077R	probably benign	Het
Dnajc18	A	G	18: 35,813,972 (GRCm39)	S266P	probably benign	Het
Dydc1	T	G	14: 40,800,647 (GRCm39)	L74R	probably damaging	Het
Echdc2	G	T	4: 108,027,067 (GRCm39)	A71S	possibly damaging	Het
Fer1l4	T	A	2: 155,886,650 (GRCm39)	D693V	probably benign	Het
Fscn3	T	C	6: 28,430,604 (GRCm39)	V258A	probably benign	Het
Herc2	T	A	7: 55,869,516 (GRCm39)	I4255N	probably damaging	Het
Il1rl2	A	G	1: 40,382,200 (GRCm39)	I171V	possibly damaging	Het
Ino80d	G	T	1: 63,097,467 (GRCm39)	T809K	probably damaging	Het
Lama2	A	T	10: 27,220,566 (GRCm39)	L433*	probably null	Het
Nlrp9c	A	T	7: 26,084,533 (GRCm39)	S349T	probably benign	Het
Parp11	T	C	6: 127,466,981 (GRCm39)	I124T	possibly damaging	Het
Parp8	A	T	13: 116,999,605 (GRCm39)		probably benign	Het
Pgm1	T	C	4: 99,827,236 (GRCm39)	F379L	probably damaging	Het
Phf21b	T	C	15: 84,671,448 (GRCm39)	H482R	probably benign	Het
Phka1	A	C	X: 101,584,716 (GRCm39)		probably null	Het
Plekhh1	T	C	12: 79,100,430 (GRCm39)	W133R	probably damaging	Het
Polr2a	A	C	11: 69,636,516 (GRCm39)	L405*	probably null	Het
Prrg3	T	A	X: 71,010,108 (GRCm39)	V3E	probably damaging	Het
Pth1r	T	C	9: 110,551,648 (GRCm39)	K484E	probably damaging	Het
Rcbtb1	T	C	14: 59,460,727 (GRCm39)	L230P	probably damaging	Het
Slc51a	G	A	16: 32,297,568 (GRCm39)	R110C	probably damaging	Het
Ssbp2	T	C	13: 91,672,720 (GRCm39)	Y27H	probably damaging	Het
Sult2a4	A	G	7: 13,665,692 (GRCm39)	V157A	probably damaging	Het
Tbx15	G	A	3: 99,259,296 (GRCm39)	S389N	probably benign	Het
Ttn	T	G	2: 76,671,424 (GRCm39)		probably benign	Het
Ube2n	T	C	10: 95,378,127 (GRCm39)		probably benign	Het
Wdr95	G	A	5: 149,505,352 (GRCm39)		probably null	Het
Wsb2	T	C	5: 117,514,620 (GRCm39)	S298P	possibly damaging	Het
Zc3h7a	T	C	16: 10,974,166 (GRCm39)		probably null	Het
Zfat	A	G	15: 68,037,758 (GRCm39)	C906R	probably damaging	Het
Zfp949	A	G	9: 88,450,717 (GRCm39)	R96G	probably benign	Het

Other mutations in Zfp747

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02964:Zfp747	APN	7	126,973,666 (GRCm39)	missense	probably benign	0.21
R0066:Zfp747	UTSW	7	126,973,772 (GRCm39)	missense	probably benign	0.00
R1056:Zfp747	UTSW	7	126,973,760 (GRCm39)	missense	probably benign
R1190:Zfp747	UTSW	7	126,973,726 (GRCm39)	missense	probably damaging	0.99
R1457:Zfp747	UTSW	7	126,973,676 (GRCm39)	missense	probably benign	0.37
R1727:Zfp747	UTSW	7	126,973,249 (GRCm39)	missense	probably damaging	0.99
R2072:Zfp747	UTSW	7	126,973,142 (GRCm39)	missense	possibly damaging	0.48
R2157:Zfp747	UTSW	7	126,974,929 (GRCm39)	missense	possibly damaging	0.92
R3724:Zfp747	UTSW	7	126,973,762 (GRCm39)	missense	probably benign	0.06
R4762:Zfp747	UTSW	7	126,973,498 (GRCm39)	missense	possibly damaging	0.92
R4770:Zfp747	UTSW	7	126,974,971 (GRCm39)	missense	probably damaging	0.99
R5135:Zfp747	UTSW	7	126,973,566 (GRCm39)	missense	probably damaging	0.98
R5355:Zfp747	UTSW	7	126,973,769 (GRCm39)	missense	possibly damaging	0.85
R6232:Zfp747	UTSW	7	126,973,306 (GRCm39)	missense	probably damaging	1.00
R6263:Zfp747	UTSW	7	126,975,138 (GRCm39)	start gained	probably benign
R6835:Zfp747	UTSW	7	126,973,219 (GRCm39)	missense	possibly damaging	0.56
R7638:Zfp747	UTSW	7	126,973,819 (GRCm39)	missense	probably benign	0.09
R7735:Zfp747	UTSW	7	126,973,672 (GRCm39)	missense	probably damaging	0.99
R8043:Zfp747	UTSW	7	126,973,225 (GRCm39)	missense	probably benign	0.00
R8543:Zfp747	UTSW	7	126,973,655 (GRCm39)	missense	probably damaging	0.99
R9132:Zfp747	UTSW	7	126,974,922 (GRCm39)	missense	probably damaging	0.99
R9329:Zfp747	UTSW	7	126,973,655 (GRCm39)	missense	probably damaging	0.99
R9415:Zfp747	UTSW	7	126,973,198 (GRCm39)	missense	possibly damaging	0.71
Z1176:Zfp747	UTSW	7	126,974,631 (GRCm39)	nonsense	probably null

Posted On

2016-08-02