Incidental Mutation 'IGL03201:Dnajc18'
ID412990
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dnajc18
Ensembl Gene ENSMUSG00000024350
Gene NameDnaJ heat shock protein family (Hsp40) member C18
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.103) question?
Stock #IGL03201
Quality Score
Status
Chromosome18
Chromosomal Location35671103-35703144 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 35680919 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 266 (S266P)
Ref Sequence ENSEMBL: ENSMUSP00000025208 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000025208]
Predicted Effect probably benign
Transcript: ENSMUST00000025208
AA Change: S266P

PolyPhen 2 Score 0.187 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000025208
Gene: ENSMUSG00000024350
AA Change: S266P

DomainStartEndE-ValueType
DnaJ 81 138 6.52e-27 SMART
low complexity region 200 218 N/A INTRINSIC
Pfam:DUF1977 243 349 1.7e-28 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4galt T C 15: 83,228,267 E105G probably damaging Het
Apc A G 18: 34,312,376 D757G probably damaging Het
Arpc3 A T 5: 122,401,718 I45F probably damaging Het
C3 C A 17: 57,222,249 V597L probably damaging Het
Ccdc181 A G 1: 164,280,644 N299D probably benign Het
Cdr1 T A X: 61,185,548 Q4L unknown Het
Cep170 G A 1: 176,736,888 S1464F probably damaging Het
Cfh A G 1: 140,102,819 Y826H probably damaging Het
Chic2 A G 5: 75,011,293 probably benign Het
Chrne T C 11: 70,618,512 H81R probably benign Het
Clec4e A G 6: 123,283,640 I153T probably benign Het
Col14a1 A T 15: 55,408,904 D699V unknown Het
Cul3 T G 1: 80,281,427 S379R probably damaging Het
Cyp3a11 T A 5: 145,860,379 I397F possibly damaging Het
Dnah1 T C 14: 31,300,949 K1077R probably benign Het
Dydc1 T G 14: 41,078,690 L74R probably damaging Het
Echdc2 G T 4: 108,169,870 A71S possibly damaging Het
Fer1l4 T A 2: 156,044,730 D693V probably benign Het
Fscn3 T C 6: 28,430,605 V258A probably benign Het
Herc2 T A 7: 56,219,768 I4255N probably damaging Het
Il1rl2 A G 1: 40,343,040 I171V possibly damaging Het
Ino80d G T 1: 63,058,308 T809K probably damaging Het
Lama2 A T 10: 27,344,570 L433* probably null Het
Nlrp9c A T 7: 26,385,108 S349T probably benign Het
Parp11 T C 6: 127,490,018 I124T possibly damaging Het
Parp8 A T 13: 116,863,069 probably benign Het
Pgm2 T C 4: 99,970,039 F379L probably damaging Het
Phf21b T C 15: 84,787,247 H482R probably benign Het
Phka1 A C X: 102,541,110 probably null Het
Plekhh1 T C 12: 79,053,656 W133R probably damaging Het
Polr2a A C 11: 69,745,690 L405* probably null Het
Prrg3 T A X: 71,966,502 V3E probably damaging Het
Pth1r T C 9: 110,722,580 K484E probably damaging Het
Rcbtb1 T C 14: 59,223,278 L230P probably damaging Het
Slc51a G A 16: 32,478,750 R110C probably damaging Het
Ssbp2 T C 13: 91,524,601 Y27H probably damaging Het
Sult2a4 A G 7: 13,931,767 V157A probably damaging Het
Tbx15 G A 3: 99,351,980 S389N probably benign Het
Ttn T G 2: 76,841,080 probably benign Het
Ube2n T C 10: 95,542,265 probably benign Het
Wdr95 G A 5: 149,581,887 probably null Het
Wsb2 T C 5: 117,376,555 S298P possibly damaging Het
Zc3h7a T C 16: 11,156,302 probably null Het
Zfat A G 15: 68,165,909 C906R probably damaging Het
Zfp747 G A 7: 127,374,008 T330I probably damaging Het
Zfp949 A G 9: 88,568,664 R96G probably benign Het
Other mutations in Dnajc18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01061:Dnajc18 APN 18 35680942 splice site probably benign
IGL01152:Dnajc18 APN 18 35680873 missense probably benign 0.02
IGL01621:Dnajc18 APN 18 35680840 missense probably benign
R1464:Dnajc18 UTSW 18 35680847 missense possibly damaging 0.88
R1464:Dnajc18 UTSW 18 35680847 missense possibly damaging 0.88
R1801:Dnajc18 UTSW 18 35680804 missense probably damaging 1.00
R3893:Dnajc18 UTSW 18 35700995 splice site probably null
R4974:Dnajc18 UTSW 18 35683319 missense possibly damaging 0.75
R5234:Dnajc18 UTSW 18 35683298 missense probably benign 0.12
R6326:Dnajc18 UTSW 18 35680925 missense possibly damaging 0.95
R6360:Dnajc18 UTSW 18 35686709 missense probably damaging 1.00
R6460:Dnajc18 UTSW 18 35700910 missense probably benign 0.41
R7215:Dnajc18 UTSW 18 35681981 missense probably benign
R7492:Dnajc18 UTSW 18 35686793 missense probably damaging 1.00
R8290:Dnajc18 UTSW 18 35683271 nonsense probably null
X0063:Dnajc18 UTSW 18 35686733 missense probably damaging 0.97
Posted On2016-08-02