Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03201:Parp8'

413001

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Parp8

Ensembl Gene

ENSMUSG00000021725

Gene Name

poly (ADP-ribose) polymerase family, member 8

Synonyms

D13Ertd275e, 2810430O08Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03201

Quality Score

Status

Chromosome

Chromosomal Location

116854820-117025537 bp(-) (GRCm38)

Type of Mutation

splice site

DNA Base Change (assembly)

A to T at 116863069 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000153188 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022239] [ENSMUST00000223949] [ENSMUST00000226107]

AlphaFold

Q3UD82

Predicted Effect

probably benign
Transcript: ENSMUST00000022239

SMART Domains

Protein: ENSMUSP00000022239
Gene: ENSMUSG00000021725

Domain	Start	End	E-Value	Type
low complexity region	5	16	N/A	INTRINSIC
low complexity region	22	34	N/A	INTRINSIC
low complexity region	163	174	N/A	INTRINSIC
low complexity region	217	228	N/A	INTRINSIC
internal_repeat_1	332	410	4.61e-10	PROSPERO
internal_repeat_1	404	476	4.61e-10	PROSPERO
low complexity region	497	514	N/A	INTRINSIC
Pfam:PARP	712	839	2e-15	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000223949

Predicted Effect

probably benign
Transcript: ENSMUST00000226107

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A4galt	T	C	15: 83,228,267	E105G	probably damaging	Het
Apc	A	G	18: 34,312,376	D757G	probably damaging	Het
Arpc3	A	T	5: 122,401,718	I45F	probably damaging	Het
C3	C	A	17: 57,222,249	V597L	probably damaging	Het
Ccdc181	A	G	1: 164,280,644	N299D	probably benign	Het
Cdr1	T	A	X: 61,185,548	Q4L	unknown	Het
Cep170	G	A	1: 176,736,888	S1464F	probably damaging	Het
Cfh	A	G	1: 140,102,819	Y826H	probably damaging	Het
Chic2	A	G	5: 75,011,293		probably benign	Het
Chrne	T	C	11: 70,618,512	H81R	probably benign	Het
Clec4e	A	G	6: 123,283,640	I153T	probably benign	Het
Col14a1	A	T	15: 55,408,904	D699V	unknown	Het
Cul3	T	G	1: 80,281,427	S379R	probably damaging	Het
Cyp3a11	T	A	5: 145,860,379	I397F	possibly damaging	Het
Dnah1	T	C	14: 31,300,949	K1077R	probably benign	Het
Dnajc18	A	G	18: 35,680,919	S266P	probably benign	Het
Dydc1	T	G	14: 41,078,690	L74R	probably damaging	Het
Echdc2	G	T	4: 108,169,870	A71S	possibly damaging	Het
Fer1l4	T	A	2: 156,044,730	D693V	probably benign	Het
Fscn3	T	C	6: 28,430,605	V258A	probably benign	Het
Herc2	T	A	7: 56,219,768	I4255N	probably damaging	Het
Il1rl2	A	G	1: 40,343,040	I171V	possibly damaging	Het
Ino80d	G	T	1: 63,058,308	T809K	probably damaging	Het
Lama2	A	T	10: 27,344,570	L433*	probably null	Het
Nlrp9c	A	T	7: 26,385,108	S349T	probably benign	Het
Parp11	T	C	6: 127,490,018	I124T	possibly damaging	Het
Pgm2	T	C	4: 99,970,039	F379L	probably damaging	Het
Phf21b	T	C	15: 84,787,247	H482R	probably benign	Het
Phka1	A	C	X: 102,541,110		probably null	Het
Plekhh1	T	C	12: 79,053,656	W133R	probably damaging	Het
Polr2a	A	C	11: 69,745,690	L405*	probably null	Het
Prrg3	T	A	X: 71,966,502	V3E	probably damaging	Het
Pth1r	T	C	9: 110,722,580	K484E	probably damaging	Het
Rcbtb1	T	C	14: 59,223,278	L230P	probably damaging	Het
Slc51a	G	A	16: 32,478,750	R110C	probably damaging	Het
Ssbp2	T	C	13: 91,524,601	Y27H	probably damaging	Het
Sult2a4	A	G	7: 13,931,767	V157A	probably damaging	Het
Tbx15	G	A	3: 99,351,980	S389N	probably benign	Het
Ttn	T	G	2: 76,841,080		probably benign	Het
Ube2n	T	C	10: 95,542,265		probably benign	Het
Wdr95	G	A	5: 149,581,887		probably null	Het
Wsb2	T	C	5: 117,376,555	S298P	possibly damaging	Het
Zc3h7a	T	C	16: 11,156,302		probably null	Het
Zfat	A	G	15: 68,165,909	C906R	probably damaging	Het
Zfp747	G	A	7: 127,374,008	T330I	probably damaging	Het
Zfp949	A	G	9: 88,568,664	R96G	probably benign	Het

Other mutations in Parp8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00916:Parp8	APN	13	116927323	missense	probably damaging	1.00
IGL01346:Parp8	APN	13	116895064	missense	possibly damaging	0.72
IGL01793:Parp8	APN	13	116910879	missense	probably damaging	1.00
IGL01926:Parp8	APN	13	116862302	splice site	probably benign
IGL01958:Parp8	APN	13	116876572	missense	probably benign	0.14
IGL02131:Parp8	APN	13	116910873	missense	probably benign	0.08
IGL02398:Parp8	APN	13	116910863	critical splice donor site	probably null
IGL02496:Parp8	APN	13	116862302	splice site	probably benign
IGL03135:Parp8	APN	13	116910942	missense	probably benign	0.41
IGL03143:Parp8	APN	13	116910961	splice site	probably benign
blondi	UTSW	13	116893041	missense	possibly damaging	0.77
Heidi	UTSW	13	116862204	splice site	probably null
R0362:Parp8	UTSW	13	116924968	nonsense	probably null
R0699:Parp8	UTSW	13	116922584	missense	probably benign	0.01
R1445:Parp8	UTSW	13	117025350	splice site	probably null
R1676:Parp8	UTSW	13	116877528	missense	probably damaging	0.99
R1977:Parp8	UTSW	13	116910913	missense	probably damaging	0.96
R2019:Parp8	UTSW	13	116868432	splice site	probably benign
R2049:Parp8	UTSW	13	116894886	missense	probably benign	0.20
R2142:Parp8	UTSW	13	116894886	missense	probably benign	0.20
R2474:Parp8	UTSW	13	116893041	missense	possibly damaging	0.77
R2566:Parp8	UTSW	13	116895687	missense	possibly damaging	0.78
R3863:Parp8	UTSW	13	116894767	missense	probably benign	0.01
R4126:Parp8	UTSW	13	116868469	missense	possibly damaging	0.94
R4518:Parp8	UTSW	13	116895673	missense	possibly damaging	0.62
R4519:Parp8	UTSW	13	116895673	missense	possibly damaging	0.62
R4767:Parp8	UTSW	13	116868536	missense	probably damaging	0.99
R5355:Parp8	UTSW	13	116862204	splice site	probably null
R5633:Parp8	UTSW	13	116876580	missense	probably damaging	1.00
R5942:Parp8	UTSW	13	116869433	missense	probably benign	0.12
R5978:Parp8	UTSW	13	116895732	missense	probably benign	0.01
R6039:Parp8	UTSW	13	116877598	missense	probably damaging	1.00
R6039:Parp8	UTSW	13	116877598	missense	probably damaging	1.00
R6753:Parp8	UTSW	13	116895115	missense	possibly damaging	0.91
R7016:Parp8	UTSW	13	116895091	missense	probably damaging	1.00
R7139:Parp8	UTSW	13	117025266	missense	probably benign	0.21
R7305:Parp8	UTSW	13	116894925	missense	possibly damaging	0.95
R7314:Parp8	UTSW	13	116868460	missense	probably benign	0.01
R7360:Parp8	UTSW	13	116895771	missense	probably benign	0.02
R7526:Parp8	UTSW	13	116894805	missense	probably damaging	1.00
R8078:Parp8	UTSW	13	116924983	missense	probably damaging	1.00
R8108:Parp8	UTSW	13	116867073	nonsense	probably null
R8372:Parp8	UTSW	13	116855250	missense	probably damaging	1.00
R9005:Parp8	UTSW	13	116876590	missense	probably benign
R9072:Parp8	UTSW	13	116911415	missense	probably damaging	1.00
R9073:Parp8	UTSW	13	116911415	missense	probably damaging	1.00
R9351:Parp8	UTSW	13	116864245	missense	probably damaging	0.99
R9441:Parp8	UTSW	13	116893026	missense	probably damaging	1.00
R9448:Parp8	UTSW	13	116902824	nonsense	probably null
R9470:Parp8	UTSW	13	116894756	missense	probably benign	0.02
R9562:Parp8	UTSW	13	116893095	missense	probably benign	0.16

Posted On

2016-08-02