Incidental Mutation 'IGL03204:Il22'
ID 413098
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il22
Ensembl Gene ENSMUSG00000074695
Gene Name interleukin 22
Synonyms IL-TIF, Iltif, IL-22
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.163) question?
Stock # IGL03204
Quality Score
Status
Chromosome 10
Chromosomal Location 118204942-118210047 bp(+) (GRCm38)
Type of Mutation splice site
DNA Base Change (assembly) C to T at 118205180 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000094449 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096691]
AlphaFold Q9JJY9
Predicted Effect probably benign
Transcript: ENSMUST00000096691
SMART Domains Protein: ENSMUSP00000094449
Gene: ENSMUSG00000074695

DomainStartEndE-ValueType
IL10 49 179 7.88e-1 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mutation of this locus results in abnormalities in Il23-induced dermal inflammation and acanthosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930452B06Rik A G 14: 8,644,436 I80T possibly damaging Het
4932438A13Rik A G 3: 37,050,934 probably benign Het
Abhd14a A T 9: 106,440,635 F191I probably damaging Het
Actc1 A T 2: 114,049,530 S201T possibly damaging Het
Ankrd36 T A 11: 5,584,023 D291E possibly damaging Het
Btbd7 T A 12: 102,807,980 R510* probably null Het
Eif4a3 A T 11: 119,293,616 D249E possibly damaging Het
Elovl6 A G 3: 129,633,344 M220V probably benign Het
Ets1 C T 9: 32,733,012 S156L possibly damaging Het
Gja8 C T 3: 96,920,092 V85I probably damaging Het
Glipr2 T A 4: 43,970,507 D7E probably benign Het
Itln1 A G 1: 171,530,604 V80A probably damaging Het
Kdr A T 5: 75,972,382 C79S possibly damaging Het
Kif26a A T 12: 112,174,779 H672L probably damaging Het
Klhl40 A T 9: 121,782,630 T570S probably benign Het
Macf1 A G 4: 123,355,277 probably benign Het
Magi3 T A 3: 104,105,835 N112I probably damaging Het
Moxd2 T C 6: 40,887,305 T64A probably benign Het
Myh4 T C 11: 67,250,296 V728A possibly damaging Het
Olfr1037 G T 2: 86,085,671 Y35* probably null Het
Prkdc A G 16: 15,769,801 I2517V probably benign Het
Ralgapb A G 2: 158,465,912 I1047V possibly damaging Het
Smg9 A G 7: 24,420,912 E437G probably benign Het
Snx4 A G 16: 33,269,669 K188R probably benign Het
Sox14 A G 9: 99,875,057 S210P probably benign Het
Spata1 A G 3: 146,488,679 F77L probably benign Het
Spata18 G T 5: 73,671,106 probably benign Het
Stard9 G A 2: 120,705,802 D4151N probably damaging Het
Wdr59 T C 8: 111,485,370 H356R probably benign Het
Zfp462 A G 4: 55,080,785 D1380G possibly damaging Het
Other mutations in Il22
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03290:Il22 APN 10 118205880 critical splice donor site probably null
PIT4651001:Il22 UTSW 10 118205590 missense probably damaging 1.00
R0184:Il22 UTSW 10 118205606 missense probably damaging 1.00
R3905:Il22 UTSW 10 118205624 nonsense probably null
R3908:Il22 UTSW 10 118205624 nonsense probably null
R4703:Il22 UTSW 10 118205606 missense probably damaging 1.00
R4797:Il22 UTSW 10 118205153 missense probably damaging 0.98
R4799:Il22 UTSW 10 118205153 missense probably damaging 0.98
R5439:Il22 UTSW 10 118209461 nonsense probably null
R5496:Il22 UTSW 10 118205097 missense possibly damaging 0.73
R5957:Il22 UTSW 10 118205166 missense probably damaging 1.00
R6584:Il22 UTSW 10 118205027 missense probably benign 0.00
R6862:Il22 UTSW 10 118205810 missense probably benign 0.41
R7381:Il22 UTSW 10 118205164 missense possibly damaging 0.48
R8095:Il22 UTSW 10 118205123 missense possibly damaging 0.95
Posted On 2016-08-02