Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03205:Naa16'

413107

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Naa16

Ensembl Gene

ENSMUSG00000022020

Gene Name

N(alpha)-acetyltransferase 16, NatA auxiliary subunit

Synonyms

1300019C06Rik, Narg1l

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.088) question?

Stock #

IGL03205

Quality Score

Status

Chromosome

Chromosomal Location

79571947-79628228 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 79593952 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 371 (T371I)

Ref Sequence

ENSEMBL: ENSMUSP00000022597 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022597] [ENSMUST00000163486]

AlphaFold

Q9DBB4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000022597
AA Change: T371I

PolyPhen 2 Score 0.889 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000022597
Gene: ENSMUSG00000022020
AA Change: T371I

Domain	Start	End	E-Value	Type
TPR	46	79	2.99e1	SMART
TPR	80	113	2.98e-3	SMART
Blast:TPR	224	257	1e-10	BLAST
TPR	374	407	9.96e0	SMART
TPR	408	441	7.47e0	SMART
low complexity region	616	633	N/A	INTRINSIC
Blast:TPR	672	705	3e-12	BLAST
low complexity region	830	841	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000163486
AA Change: T337I

PolyPhen 2 Score 0.837 (Sensitivity: 0.84; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000131268
Gene: ENSMUSG00000022020
AA Change: T337I

Domain	Start	End	E-Value	Type
TPR	12	45	2.99e1	SMART
TPR	46	79	2.98e-3	SMART
Blast:TPR	190	223	3e-10	BLAST
TPR	340	373	9.96e0	SMART
TPR	374	407	7.47e0	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bsph2	A	T	7: 13,290,301 (GRCm39)	D120E	probably damaging	Het
Casp14	A	G	10: 78,549,173 (GRCm39)	*258Q	probably null	Het
Ccdc54	A	C	16: 50,411,254 (GRCm39)	F4C	possibly damaging	Het
Clcn4	C	T	7: 7,293,419 (GRCm39)	V475M	probably damaging	Het
D630045J12Rik	C	T	6: 38,124,194 (GRCm39)	R1586H	probably damaging	Het
Eml4	T	A	17: 83,761,873 (GRCm39)	S453R	probably damaging	Het
Flt1	T	C	5: 147,636,631 (GRCm39)	K118E	probably benign	Het
Kif20b	A	T	19: 34,936,863 (GRCm39)	E154D	probably damaging	Het
Meis2	C	T	2: 115,694,731 (GRCm39)	V471I	probably benign	Het
Naa20	A	G	2: 145,745,251 (GRCm39)	T8A	possibly damaging	Het
Or13a28	G	A	7: 140,218,073 (GRCm39)	C153Y	possibly damaging	Het
Pla2g6	G	A	15: 79,201,985 (GRCm39)	P62L	probably damaging	Het
Pmel	A	G	10: 128,552,317 (GRCm39)	T384A	probably benign	Het
Ryr3	T	C	2: 112,462,487 (GRCm39)	Y4863C	probably damaging	Het
Slc4a4	G	A	5: 89,297,189 (GRCm39)	V510I	probably benign	Het
Smad3	T	A	9: 63,575,148 (GRCm39)	Y23F	probably benign	Het
Sugt1	G	A	14: 79,834,241 (GRCm39)	A81T	probably damaging	Het
Svs3b	A	T	2: 164,098,181 (GRCm39)	F47I	probably damaging	Het
Thbs4	T	C	13: 92,899,282 (GRCm39)	D571G	probably damaging	Het
Trav15-1-dv6-1	T	C	14: 53,797,485 (GRCm39)	Y45H	probably damaging	Het
Zbtb5	A	T	4: 44,994,949 (GRCm39)	M145K	probably damaging	Het

Other mutations in Naa16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00551:Naa16	APN	14	79,593,169 (GRCm39)	missense	probably damaging	1.00
IGL01025:Naa16	APN	14	79,622,196 (GRCm39)	missense	probably damaging	1.00
IGL01155:Naa16	APN	14	79,622,155 (GRCm39)	missense	probably damaging	0.98
IGL01335:Naa16	APN	14	79,582,556 (GRCm39)	splice site	probably benign
IGL01981:Naa16	APN	14	79,618,956 (GRCm39)	missense	probably benign	0.05
IGL02230:Naa16	APN	14	79,614,801 (GRCm39)	splice site	probably benign
IGL02313:Naa16	APN	14	79,622,108 (GRCm39)	missense	probably damaging	1.00
IGL02418:Naa16	APN	14	79,620,806 (GRCm39)	missense	probably damaging	1.00
IGL02544:Naa16	APN	14	79,573,260 (GRCm39)	missense	probably damaging	1.00
IGL03051:Naa16	APN	14	79,606,522 (GRCm39)	missense	probably benign	0.01
IGL03064:Naa16	APN	14	79,577,068 (GRCm39)	missense	probably damaging	0.98
PIT4508001:Naa16	UTSW	14	79,606,527 (GRCm39)	missense	probably benign	0.15
R0651:Naa16	UTSW	14	79,588,832 (GRCm39)	missense	probably damaging	1.00
R1429:Naa16	UTSW	14	79,596,967 (GRCm39)	missense	probably benign	0.01
R1674:Naa16	UTSW	14	79,624,497 (GRCm39)	start codon destroyed	probably null	0.65
R1693:Naa16	UTSW	14	79,588,896 (GRCm39)	missense	probably damaging	1.00
R1874:Naa16	UTSW	14	79,593,183 (GRCm39)	missense	possibly damaging	0.62
R1992:Naa16	UTSW	14	79,593,931 (GRCm39)	missense	probably damaging	1.00
R2015:Naa16	UTSW	14	79,582,499 (GRCm39)	missense	probably damaging	1.00
R2391:Naa16	UTSW	14	79,607,489 (GRCm39)	missense	probably benign	0.16
R2847:Naa16	UTSW	14	79,573,323 (GRCm39)	missense	probably damaging	1.00
R2848:Naa16	UTSW	14	79,573,323 (GRCm39)	missense	probably damaging	1.00
R2877:Naa16	UTSW	14	79,580,738 (GRCm39)	missense	probably benign	0.00
R3884:Naa16	UTSW	14	79,580,702 (GRCm39)	missense	probably damaging	0.98
R4001:Naa16	UTSW	14	79,580,561 (GRCm39)	splice site	probably null
R4199:Naa16	UTSW	14	79,593,311 (GRCm39)	missense	probably damaging	1.00
R4638:Naa16	UTSW	14	79,577,473 (GRCm39)	splice site	probably null
R4676:Naa16	UTSW	14	79,573,788 (GRCm39)	unclassified	probably benign
R4690:Naa16	UTSW	14	79,582,497 (GRCm39)	missense	probably damaging	1.00
R4952:Naa16	UTSW	14	79,582,525 (GRCm39)	missense	probably damaging	1.00
R5087:Naa16	UTSW	14	79,614,855 (GRCm39)	missense	possibly damaging	0.68
R5104:Naa16	UTSW	14	79,622,140 (GRCm39)	nonsense	probably null
R5729:Naa16	UTSW	14	79,593,220 (GRCm39)	missense	probably damaging	1.00
R6178:Naa16	UTSW	14	79,620,780 (GRCm39)	missense	possibly damaging	0.93
R6960:Naa16	UTSW	14	79,596,911 (GRCm39)	missense	possibly damaging	0.65
R7794:Naa16	UTSW	14	79,614,934 (GRCm39)	missense	probably damaging	1.00
R7936:Naa16	UTSW	14	79,578,486 (GRCm39)	missense	possibly damaging	0.47
R8356:Naa16	UTSW	14	79,596,915 (GRCm39)	missense	probably benign	0.00
R8456:Naa16	UTSW	14	79,596,915 (GRCm39)	missense	probably benign	0.00
R8892:Naa16	UTSW	14	79,628,016 (GRCm39)	missense	probably benign	0.32
R8931:Naa16	UTSW	14	79,582,395 (GRCm39)	missense	probably damaging	1.00
R9010:Naa16	UTSW	14	79,607,482 (GRCm39)	missense	probably benign	0.01
R9068:Naa16	UTSW	14	79,612,289 (GRCm39)	missense	probably benign	0.18
R9360:Naa16	UTSW	14	79,593,943 (GRCm39)	missense	probably benign	0.05
R9688:Naa16	UTSW	14	79,573,309 (GRCm39)	nonsense	probably null
X0064:Naa16	UTSW	14	79,588,829 (GRCm39)	missense	probably damaging	1.00
Z1177:Naa16	UTSW	14	79,582,419 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02