Incidental Mutation 'IGL03207:Mrgpra9'
ID413169
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgpra9
Ensembl Gene ENSMUSG00000074111
Gene NameMAS-related GPR, member A9
SynonymsEG668725, MrgA9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.050) question?
Stock #IGL03207
Quality Score
Status
Chromosome7
Chromosomal Location47234861-47252848 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 47235637 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 94 (I94T)
Ref Sequence ENSEMBL: ENSMUSP00000136396 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098436] [ENSMUST00000179005]
Predicted Effect possibly damaging
Transcript: ENSMUST00000098436
AA Change: I93T

PolyPhen 2 Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000096035
Gene: ENSMUSG00000074111
AA Change: I93T

DomainStartEndE-ValueType
low complexity region 37 48 N/A INTRINSIC
Pfam:7tm_1 56 225 1.5e-11 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000179005
AA Change: I94T

PolyPhen 2 Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000136396
Gene: ENSMUSG00000074111
AA Change: I94T

DomainStartEndE-ValueType
Pfam:7tm_1 12 178 3.4e-9 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik T C 3: 36,949,996 I1619T possibly damaging Het
Adgrv1 C T 13: 81,106,898 probably null Het
Agt A G 8: 124,559,368 F325S probably damaging Het
Arnt2 T C 7: 84,343,834 E166G possibly damaging Het
Cacna1h T C 17: 25,391,333 D733G probably damaging Het
Capn2 T G 1: 182,489,013 T294P possibly damaging Het
Cd74 A G 18: 60,811,924 probably benign Het
Eno4 T C 19: 58,953,205 L185P probably benign Het
Exoc5 G A 14: 49,033,375 P398S probably benign Het
Fsd2 T C 7: 81,559,170 M187V probably benign Het
Lrfn5 C T 12: 61,843,326 T467M probably damaging Het
Nuak1 A C 10: 84,440,129 F77V possibly damaging Het
Nudt9 T C 5: 104,058,226 probably benign Het
Olfr1019 A G 2: 85,840,973 W273R probably benign Het
Ppp3cc T A 14: 70,247,582 I208F probably damaging Het
Prrc1 G A 18: 57,389,317 R407Q probably benign Het
Ror1 G A 4: 100,407,945 probably null Het
Tmem161b T A 13: 84,294,595 probably benign Het
Wdr35 C A 12: 8,989,936 A347E probably damaging Het
Other mutations in Mrgpra9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Mrgpra9 APN 7 47235091 missense possibly damaging 0.85
IGL00575:Mrgpra9 APN 7 47235305 missense possibly damaging 0.76
IGL01649:Mrgpra9 APN 7 47235152 missense probably benign 0.22
R0388:Mrgpra9 UTSW 7 47252794 start codon destroyed probably null 0.08
R0972:Mrgpra9 UTSW 7 47235455 missense probably damaging 0.99
R1270:Mrgpra9 UTSW 7 47252783 critical splice donor site probably null
R1381:Mrgpra9 UTSW 7 47235302 missense possibly damaging 0.75
R1403:Mrgpra9 UTSW 7 47235638 missense probably benign 0.24
R1403:Mrgpra9 UTSW 7 47235638 missense probably benign 0.24
R1448:Mrgpra9 UTSW 7 47235813 missense probably benign 0.02
R2045:Mrgpra9 UTSW 7 47235835 missense probably benign
R2144:Mrgpra9 UTSW 7 47235463 missense probably benign 0.31
R2187:Mrgpra9 UTSW 7 47235049 missense probably damaging 1.00
R2507:Mrgpra9 UTSW 7 47235494 missense possibly damaging 0.63
R2913:Mrgpra9 UTSW 7 47235080 missense probably benign
R3810:Mrgpra9 UTSW 7 47235779 missense probably damaging 0.98
R4177:Mrgpra9 UTSW 7 47235554 missense probably damaging 1.00
R4521:Mrgpra9 UTSW 7 47235190 missense probably damaging 1.00
R4781:Mrgpra9 UTSW 7 47235047 missense possibly damaging 0.88
R4926:Mrgpra9 UTSW 7 47235011 missense possibly damaging 0.62
R6469:Mrgpra9 UTSW 7 47235106 missense probably benign 0.02
R6505:Mrgpra9 UTSW 7 47235136 missense probably benign 0.00
R6724:Mrgpra9 UTSW 7 47235038 missense probably damaging 1.00
R7398:Mrgpra9 UTSW 7 47235637 missense possibly damaging 0.68
Posted On2016-08-02