Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03209:Lvrn'

413215

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lvrn

Ensembl Gene

ENSMUSG00000024481

Gene Name

laeverin

Synonyms

4833403I15Rik, Aqpep

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.374) question?

Stock #

IGL03209

Quality Score

Status

Chromosome

Chromosomal Location

46983105-47040309 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 47022565 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 734 (I734V)

Ref Sequence

ENSEMBL: ENSMUSP00000025358 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025358]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000025358
AA Change: I734V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000025358
Gene: ENSMUSG00000024481
AA Change: I734V

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
Pfam:Peptidase_M1	94	504	1.6e-110	PFAM
Pfam:ERAP1_C	645	968	2.5e-60	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts13	C	T	2: 26,882,973 (GRCm39)	A841V	probably benign	Het
Alms1	A	G	6: 85,576,955 (GRCm39)		probably benign	Het
Arc	A	T	15: 74,543,833 (GRCm39)	L130Q	probably damaging	Het
Arhgap28	C	T	17: 68,175,951 (GRCm39)	V383I	probably damaging	Het
Atf6	T	C	1: 170,662,463 (GRCm39)	S266G	probably benign	Het
Cd59b	A	G	2: 103,914,905 (GRCm39)	E101G	probably benign	Het
Cdc26	T	C	4: 62,313,251 (GRCm39)	K30R	possibly damaging	Het
Clns1a	A	G	7: 97,360,937 (GRCm39)	D103G	probably null	Het
Crispld2	C	A	8: 120,757,837 (GRCm39)	A394E	possibly damaging	Het
Cyp51	A	T	5: 4,154,195 (GRCm39)	L38H	probably damaging	Het
Dnah7a	T	G	1: 53,725,773 (GRCm39)		probably benign	Het
Fbxw2	T	C	2: 34,712,675 (GRCm39)	R129G	probably damaging	Het
Fgd3	T	C	13: 49,439,294 (GRCm39)	Q234R	probably damaging	Het
Gdpgp1	A	G	7: 79,888,847 (GRCm39)	T293A	probably damaging	Het
Hspa12a	T	G	19: 58,810,493 (GRCm39)		probably null	Het
Ier5l	G	T	2: 30,363,067 (GRCm39)	D319E	possibly damaging	Het
Iigp1c	T	A	18: 60,379,143 (GRCm39)	I226N	probably damaging	Het
Ikzf1	T	C	11: 11,650,226 (GRCm39)	V3A	probably benign	Het
Itga2	T	C	13: 115,017,168 (GRCm39)	N180D	probably damaging	Het
Lipt1	T	C	1: 37,914,150 (GRCm39)	S69P	probably damaging	Het
Man2c1	A	G	9: 57,049,114 (GRCm39)	T871A	probably benign	Het
Ndufs1	A	T	1: 63,203,896 (GRCm39)	C129S	probably damaging	Het
Neb	A	T	2: 52,180,831 (GRCm39)	F1232I	probably damaging	Het
Ngly1	T	A	14: 16,281,831 (GRCm38)	Y362*	probably null	Het
Or2h2c	A	T	17: 37,422,413 (GRCm39)	S154T	probably benign	Het
Or5ak23	A	T	2: 85,244,723 (GRCm39)	S167T	probably benign	Het
Patj	A	G	4: 98,353,377 (GRCm39)	D640G	probably null	Het
Plxnd1	A	T	6: 115,939,318 (GRCm39)	M1502K	probably damaging	Het
Sccpdh	T	C	1: 179,514,238 (GRCm39)	V429A	possibly damaging	Het
Slc25a48	T	C	13: 56,618,272 (GRCm39)	V303A	probably benign	Het
Sult2a6	T	C	7: 13,959,897 (GRCm39)	D212G	probably benign	Het
Tep1	A	T	14: 51,078,160 (GRCm39)		probably benign	Het
Tmem65	A	G	15: 58,656,751 (GRCm39)		probably benign	Het
Togaram2	T	C	17: 72,002,740 (GRCm39)		probably null	Het
Trim36	T	C	18: 46,300,575 (GRCm39)	T687A	probably benign	Het
Unc13b	T	A	4: 43,239,351 (GRCm39)	D3471E	probably damaging	Het
Urgcp	T	C	11: 5,667,238 (GRCm39)		probably null	Het
Zfhx4	A	T	3: 5,466,231 (GRCm39)	I2155F	probably damaging	Het
Zfp831	T	A	2: 174,487,059 (GRCm39)	V578E	probably benign	Het

Other mutations in Lvrn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Lvrn	APN	18	46,997,733 (GRCm39)	splice site	probably benign
IGL01532:Lvrn	APN	18	47,033,551 (GRCm39)	missense	probably damaging	1.00
IGL02430:Lvrn	APN	18	47,027,797 (GRCm39)	missense	probably benign	0.03
IGL02573:Lvrn	APN	18	47,010,016 (GRCm39)	missense	probably damaging	0.98
IGL02592:Lvrn	APN	18	46,983,658 (GRCm39)	missense	probably damaging	1.00
IGL02754:Lvrn	APN	18	47,023,971 (GRCm39)	nonsense	probably null
IGL03089:Lvrn	APN	18	47,013,776 (GRCm39)	missense	probably damaging	0.99
IGL03333:Lvrn	APN	18	46,997,731 (GRCm39)	splice site	probably benign
IGL03098:Lvrn	UTSW	18	47,014,477 (GRCm39)	critical splice acceptor site	probably null
R0319:Lvrn	UTSW	18	46,997,820 (GRCm39)	missense	probably damaging	1.00
R0391:Lvrn	UTSW	18	46,983,533 (GRCm39)	missense	probably benign	0.01
R0398:Lvrn	UTSW	18	47,013,760 (GRCm39)	missense	probably benign	0.06
R0432:Lvrn	UTSW	18	47,038,366 (GRCm39)	missense	possibly damaging	0.94
R0456:Lvrn	UTSW	18	46,997,883 (GRCm39)	critical splice donor site	probably null
R1458:Lvrn	UTSW	18	47,015,452 (GRCm39)	splice site	probably benign
R1612:Lvrn	UTSW	18	47,027,770 (GRCm39)	missense	probably damaging	0.99
R1935:Lvrn	UTSW	18	47,011,387 (GRCm39)	missense	probably benign	0.10
R1936:Lvrn	UTSW	18	47,011,387 (GRCm39)	missense	probably benign	0.10
R1959:Lvrn	UTSW	18	47,027,784 (GRCm39)	missense	probably damaging	1.00
R2000:Lvrn	UTSW	18	47,038,374 (GRCm39)	missense	probably benign	0.04
R2022:Lvrn	UTSW	18	46,999,503 (GRCm39)	missense	possibly damaging	0.81
R2106:Lvrn	UTSW	18	47,011,356 (GRCm39)	missense	probably damaging	1.00
R2197:Lvrn	UTSW	18	47,011,409 (GRCm39)	missense	probably benign	0.03
R2371:Lvrn	UTSW	18	47,011,230 (GRCm39)	splice site	probably null
R4125:Lvrn	UTSW	18	47,010,036 (GRCm39)	missense	possibly damaging	0.53
R4606:Lvrn	UTSW	18	46,997,832 (GRCm39)	missense	possibly damaging	0.92
R4830:Lvrn	UTSW	18	47,038,418 (GRCm39)	missense	probably damaging	1.00
R4866:Lvrn	UTSW	18	47,026,768 (GRCm39)	missense	probably damaging	1.00
R4900:Lvrn	UTSW	18	47,014,479 (GRCm39)	missense	probably damaging	1.00
R4900:Lvrn	UTSW	18	47,026,768 (GRCm39)	missense	probably damaging	1.00
R4924:Lvrn	UTSW	18	47,027,792 (GRCm39)	missense	probably damaging	1.00
R4948:Lvrn	UTSW	18	47,013,803 (GRCm39)	missense	probably damaging	1.00
R5167:Lvrn	UTSW	18	47,013,814 (GRCm39)	missense	probably damaging	0.99
R5527:Lvrn	UTSW	18	47,006,870 (GRCm39)	missense	probably damaging	1.00
R5581:Lvrn	UTSW	18	47,023,932 (GRCm39)	missense	probably benign	0.17
R5615:Lvrn	UTSW	18	46,983,395 (GRCm39)	missense	possibly damaging	0.55
R5859:Lvrn	UTSW	18	47,026,816 (GRCm39)	missense	probably damaging	1.00
R6149:Lvrn	UTSW	18	47,017,499 (GRCm39)	missense	probably benign	0.10
R6183:Lvrn	UTSW	18	46,983,752 (GRCm39)	missense	probably benign	0.14
R6378:Lvrn	UTSW	18	47,028,024 (GRCm39)	missense	probably benign	0.00
R6838:Lvrn	UTSW	18	47,023,947 (GRCm39)	missense	possibly damaging	0.88
R6993:Lvrn	UTSW	18	47,015,365 (GRCm39)	missense	probably benign	0.18
R7017:Lvrn	UTSW	18	46,983,745 (GRCm39)	missense	probably benign	0.00
R7168:Lvrn	UTSW	18	47,014,389 (GRCm39)	missense	probably benign	0.29
R7190:Lvrn	UTSW	18	47,033,570 (GRCm39)	missense	probably benign	0.02
R7315:Lvrn	UTSW	18	47,010,051 (GRCm39)	missense	probably benign	0.34
R8293:Lvrn	UTSW	18	46,983,632 (GRCm39)	missense	possibly damaging	0.75
R8375:Lvrn	UTSW	18	46,983,289 (GRCm39)	missense	probably damaging	0.98
R9563:Lvrn	UTSW	18	47,017,506 (GRCm39)	missense	probably damaging	1.00
R9564:Lvrn	UTSW	18	47,017,506 (GRCm39)	missense	probably damaging	1.00
R9565:Lvrn	UTSW	18	47,017,506 (GRCm39)	missense	probably damaging	1.00
R9585:Lvrn	UTSW	18	47,011,411 (GRCm39)	critical splice donor site	probably null
R9599:Lvrn	UTSW	18	46,999,494 (GRCm39)	missense	probably benign	0.37
R9694:Lvrn	UTSW	18	47,033,609 (GRCm39)	missense	probably damaging	1.00
R9709:Lvrn	UTSW	18	47,006,847 (GRCm39)	critical splice acceptor site	probably null

Posted On

2016-08-02