Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03210:Nol4l'

413291

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nol4l

Ensembl Gene

ENSMUSG00000061411

Gene Name

nucleolar protein 4-like

Synonyms

8430427H17Rik, LOC381396

Accession Numbers

Essential gene?

Probably essential (E-score: 0.906) question?

Stock #

IGL03210

Quality Score

Status

Chromosome

Chromosomal Location

153249381-153371869 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 153371378 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Proline to Leucine at position 102 (P102L)

Ref Sequence

ENSEMBL: ENSMUSP00000036571 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000035346]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000035346
AA Change: P102L

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000036571
Gene: ENSMUSG00000061411
AA Change: P102L

Domain	Start	End	E-Value	Type
low complexity region	58	71	N/A	INTRINSIC
low complexity region	277	305	N/A	INTRINSIC
low complexity region	405	422	N/A	INTRINSIC
low complexity region	619	639	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921539E11Rik	A	G	4: 103,141,635 (GRCm39)	F9L	probably benign	Het
Adora3	T	C	3: 105,815,176 (GRCm39)	S163P	probably benign	Het
Ark2c	C	A	18: 77,554,435 (GRCm39)	V60L	probably damaging	Het
C3	G	A	17: 57,522,846 (GRCm39)	Q1013*	probably null	Het
Cacna1b	A	T	2: 24,540,584 (GRCm39)	F1381Y	probably benign	Het
Dcdc2b	T	C	4: 129,505,578 (GRCm39)	K95R	probably benign	Het
Dnah8	A	G	17: 31,034,639 (GRCm39)	E4186G	probably damaging	Het
Dock1	T	C	7: 134,358,668 (GRCm39)	V374A	possibly damaging	Het
Gramd2b	A	G	18: 56,607,170 (GRCm39)	T95A	probably benign	Het
Grk2	C	T	19: 4,337,857 (GRCm39)	E508K	probably benign	Het
Hmgb4	A	G	4: 128,154,535 (GRCm39)	V11A	probably benign	Het
Knl1	G	A	2: 118,901,098 (GRCm39)	S933N	probably benign	Het
Ldlrad3	G	A	2: 101,900,271 (GRCm39)		probably benign	Het
Lrrc37a	T	A	11: 103,390,331 (GRCm39)	Y1698F	probably benign	Het
Ms4a14	A	G	19: 11,279,325 (GRCm39)	W1078R	possibly damaging	Het
Nsun3	A	G	16: 62,591,110 (GRCm39)	F178L	probably damaging	Het
Nup85	T	A	11: 115,457,462 (GRCm39)	Y55N	probably benign	Het
Opcml	A	G	9: 28,812,833 (GRCm39)	E175G	probably damaging	Het
Or10a3m	T	A	7: 108,312,775 (GRCm39)	Y60N	probably damaging	Het
Or11g7	A	T	14: 50,691,440 (GRCm39)	R310S	probably benign	Het
Or9g4	T	C	2: 85,504,697 (GRCm39)	Y266C	probably damaging	Het
Pask	A	T	1: 93,247,714 (GRCm39)	W1074R	possibly damaging	Het
Pdzrn3	T	C	6: 101,133,913 (GRCm39)	T439A	possibly damaging	Het
Pkd1l1	C	A	11: 8,915,127 (GRCm39)	V138L	unknown	Het
Ptprj	C	A	2: 90,300,070 (GRCm39)	V244L	probably benign	Het
Rapgef5	A	G	12: 117,706,607 (GRCm39)	K697E	probably damaging	Het
Rp9	G	T	9: 22,368,724 (GRCm39)	H78Q	probably benign	Het
Serpinb8	A	G	1: 107,530,641 (GRCm39)	T140A	probably damaging	Het
Slc29a4	A	T	5: 142,700,863 (GRCm39)	M203L	probably damaging	Het
Stag1	T	A	9: 100,727,129 (GRCm39)	L363I	possibly damaging	Het
Susd1	T	G	4: 59,333,035 (GRCm39)		probably null	Het
Thoc3	A	T	13: 54,614,035 (GRCm39)	M196K	probably benign	Het
Tnr	A	G	1: 159,715,880 (GRCm39)	T881A	probably benign	Het
Ttbk2	A	G	2: 120,652,973 (GRCm39)	V17A	probably damaging	Het
Ttc41	T	A	10: 86,560,278 (GRCm39)		probably null	Het
Utp14b	A	G	1: 78,643,268 (GRCm39)	M389V	probably benign	Het
Utp4	T	A	8: 107,642,888 (GRCm39)	H515Q	probably benign	Het
Xpo1	A	G	11: 23,228,834 (GRCm39)	H223R	probably benign	Het
Xpot	A	G	10: 121,451,132 (GRCm39)		probably benign	Het
Zfp455	A	T	13: 67,355,113 (GRCm39)	H127L	possibly damaging	Het
Zscan4e	T	A	7: 11,041,459 (GRCm39)	M166L	probably benign	Het

Other mutations in Nol4l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00933:Nol4l	APN	2	153,319,856 (GRCm39)	missense	probably damaging	0.96
IGL01325:Nol4l	APN	2	153,278,271 (GRCm39)	splice site	probably benign
IGL02608:Nol4l	APN	2	153,278,213 (GRCm39)	missense	possibly damaging	0.50
IGL02886:Nol4l	APN	2	153,371,457 (GRCm39)	missense	probably benign	0.27
IGL03055:Nol4l	UTSW	2	153,278,190 (GRCm39)	synonymous	silent
R0285:Nol4l	UTSW	2	153,325,773 (GRCm39)	splice site	probably benign
R0345:Nol4l	UTSW	2	153,253,672 (GRCm39)	missense	probably benign	0.00
R0555:Nol4l	UTSW	2	153,259,604 (GRCm39)	splice site	probably null
R1966:Nol4l	UTSW	2	153,371,375 (GRCm39)	missense	probably benign	0.01
R2044:Nol4l	UTSW	2	153,371,441 (GRCm39)	missense	possibly damaging	0.66
R2368:Nol4l	UTSW	2	153,259,959 (GRCm39)	missense	probably damaging	1.00
R4855:Nol4l	UTSW	2	153,253,726 (GRCm39)	missense	probably benign	0.06
R5696:Nol4l	UTSW	2	153,260,026 (GRCm39)	missense	probably damaging	0.99
R5776:Nol4l	UTSW	2	153,259,741 (GRCm39)	missense	probably damaging	1.00
R6807:Nol4l	UTSW	2	153,325,746 (GRCm39)	nonsense	probably null
R6845:Nol4l	UTSW	2	153,258,582 (GRCm39)	missense	probably benign	0.00
R6872:Nol4l	UTSW	2	153,325,737 (GRCm39)	missense	probably damaging	0.98
R6940:Nol4l	UTSW	2	153,253,684 (GRCm39)	missense	probably benign	0.00
R8165:Nol4l	UTSW	2	153,262,473 (GRCm39)	nonsense	probably null
R8263:Nol4l	UTSW	2	153,259,337 (GRCm39)	missense	probably damaging	0.99
R8500:Nol4l	UTSW	2	153,278,266 (GRCm39)	missense	probably damaging	0.99
R8938:Nol4l	UTSW	2	153,262,651 (GRCm39)	missense	probably damaging	1.00
R9097:Nol4l	UTSW	2	153,312,630 (GRCm39)	missense	probably damaging	0.96
R9098:Nol4l	UTSW	2	153,312,630 (GRCm39)	missense	probably damaging	0.96
R9099:Nol4l	UTSW	2	153,312,630 (GRCm39)	missense	probably damaging	0.96
R9115:Nol4l	UTSW	2	153,253,638 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02