Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03210:Ttc41'

413293

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ttc41

Ensembl Gene

ENSMUSG00000044937

Gene Name

tetratricopeptide repeat domain 41

Synonyms

Gnn, BC030307

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.146) question?

Stock #

IGL03210

Quality Score

Status

Chromosome

Chromosomal Location

86705811-86776844 bp(+) (GRCm38)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to A at 86724414 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000151920 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061458] [ENSMUST00000075632] [ENSMUST00000217747] [ENSMUST00000219108]

AlphaFold

no structure available at present

Predicted Effect

silent
Transcript: ENSMUST00000061458

SMART Domains

Protein: ENSMUSP00000062844
Gene: ENSMUSG00000044937

Domain	Start	End	E-Value	Type
low complexity region	216	229	N/A	INTRINSIC
low complexity region	307	315	N/A	INTRINSIC
Blast:AAA	336	401	9e-8	BLAST
SCOP:d1jpna2	338	370	1e-3	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000075632

SMART Domains

Protein: ENSMUSP00000075059
Gene: ENSMUSG00000044937

Domain	Start	End	E-Value	Type
low complexity region	216	229	N/A	INTRINSIC
low complexity region	307	315	N/A	INTRINSIC
Pfam:NACHT	337	515	5.4e-10	PFAM
SCOP:d1qqea_	805	1028	2e-5	SMART

Predicted Effect

silent
Transcript: ENSMUST00000217747

Predicted Effect

probably null
Transcript: ENSMUST00000219108

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921539E11Rik	A	G	4: 103,284,438	F9L	probably benign	Het
Adora3	T	C	3: 105,907,860	S163P	probably benign	Het
C3	G	A	17: 57,215,846	Q1013*	probably null	Het
Cacna1b	A	T	2: 24,650,572	F1381Y	probably benign	Het
Dcdc2b	T	C	4: 129,611,785	K95R	probably benign	Het
Dnah8	A	G	17: 30,815,665	E4186G	probably damaging	Het
Dock1	T	C	7: 134,756,939	V374A	possibly damaging	Het
Gramd3	A	G	18: 56,474,098	T95A	probably benign	Het
Grk2	C	T	19: 4,287,829	E508K	probably benign	Het
Hmgb4	A	G	4: 128,260,742	V11A	probably benign	Het
Knl1	G	A	2: 119,070,617	S933N	probably benign	Het
Ldlrad3	G	A	2: 102,069,926		probably benign	Het
Lrrc37a	T	A	11: 103,499,505	Y1698F	probably benign	Het
Ms4a14	A	G	19: 11,301,961	W1078R	possibly damaging	Het
Nol4l	G	A	2: 153,529,458	P102L	probably benign	Het
Nsun3	A	G	16: 62,770,747	F178L	probably damaging	Het
Nup85	T	A	11: 115,566,636	Y55N	probably benign	Het
Olfr1006	T	C	2: 85,674,353	Y266C	probably damaging	Het
Olfr512	T	A	7: 108,713,568	Y60N	probably damaging	Het
Olfr740	A	T	14: 50,453,983	R310S	probably benign	Het
Opcml	A	G	9: 28,901,537	E175G	probably damaging	Het
Pask	A	T	1: 93,319,992	W1074R	possibly damaging	Het
Pdzrn3	T	C	6: 101,156,952	T439A	possibly damaging	Het
Pkd1l1	C	A	11: 8,965,127	V138L	unknown	Het
Ptprj	C	A	2: 90,469,726	V244L	probably benign	Het
Rapgef5	A	G	12: 117,742,872	K697E	probably damaging	Het
Rnf165	C	A	18: 77,466,739	V60L	probably damaging	Het
Rp9	G	T	9: 22,457,428	H78Q	probably benign	Het
Serpinb8	A	G	1: 107,602,911	T140A	probably damaging	Het
Slc29a4	A	T	5: 142,715,108	M203L	probably damaging	Het
Stag1	T	A	9: 100,845,076	L363I	possibly damaging	Het
Susd1	T	G	4: 59,333,035		probably null	Het
Thoc3	A	T	13: 54,466,222	M196K	probably benign	Het
Tnr	A	G	1: 159,888,310	T881A	probably benign	Het
Ttbk2	A	G	2: 120,822,492	V17A	probably damaging	Het
Utp14b	A	G	1: 78,665,551	M389V	probably benign	Het
Utp4	T	A	8: 106,916,256	H515Q	probably benign	Het
Xpo1	A	G	11: 23,278,834	H223R	probably benign	Het
Xpot	A	G	10: 121,615,227		probably benign	Het
Zfp455	A	T	13: 67,207,049	H127L	possibly damaging	Het
Zscan4e	T	A	7: 11,307,532	M166L	probably benign	Het

Other mutations in Ttc41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00846:Ttc41	APN	10	86,736,933 (GRCm38)	missense	possibly damaging	0.71
IGL01373:Ttc41	APN	10	86,775,957 (GRCm38)	missense	possibly damaging	0.61
IGL01636:Ttc41	APN	10	86,776,678 (GRCm38)	missense	probably benign
IGL01707:Ttc41	APN	10	86,776,767 (GRCm38)	missense	probably damaging	1.00
IGL01814:Ttc41	APN	10	86,731,026 (GRCm38)	missense	probably damaging	0.98
IGL01845:Ttc41	APN	10	86,776,624 (GRCm38)	missense	probably benign	0.03
IGL01918:Ttc41	APN	10	86,713,190 (GRCm38)	missense	probably damaging	1.00
IGL02374:Ttc41	APN	10	86,775,951 (GRCm38)	missense	probably damaging	1.00
IGL02489:Ttc41	APN	10	86,760,914 (GRCm38)	nonsense	probably null
IGL02887:Ttc41	APN	10	86,733,654 (GRCm38)	missense	probably damaging	1.00
IGL03061:Ttc41	APN	10	86,736,857 (GRCm38)	missense	possibly damaging	0.65
IGL03077:Ttc41	APN	10	86,758,348 (GRCm38)	missense	probably damaging	1.00
IGL03242:Ttc41	APN	10	86,776,819 (GRCm38)	makesense	probably null
IGL03307:Ttc41	APN	10	86,744,440 (GRCm38)	missense	possibly damaging	0.76
BB003:Ttc41	UTSW	10	86,776,047 (GRCm38)	missense	probably benign	0.10
BB013:Ttc41	UTSW	10	86,776,047 (GRCm38)	missense	probably benign	0.10
R0071:Ttc41	UTSW	10	86,736,846 (GRCm38)	missense	probably benign	0.01
R0071:Ttc41	UTSW	10	86,736,846 (GRCm38)	missense	probably benign	0.01
R0379:Ttc41	UTSW	10	86,712,977 (GRCm38)	missense	possibly damaging	0.65
R0384:Ttc41	UTSW	10	86,763,947 (GRCm38)	missense	probably damaging	1.00
R0545:Ttc41	UTSW	10	86,759,097 (GRCm38)	missense	probably benign	0.00
R1589:Ttc41	UTSW	10	86,776,390 (GRCm38)	missense	probably benign	0.01
R1599:Ttc41	UTSW	10	86,776,573 (GRCm38)	missense	probably benign	0.04
R1608:Ttc41	UTSW	10	86,775,993 (GRCm38)	missense	probably damaging	1.00
R1670:Ttc41	UTSW	10	86,776,252 (GRCm38)	missense	possibly damaging	0.93
R1938:Ttc41	UTSW	10	86,776,214 (GRCm38)	missense	probably benign
R2398:Ttc41	UTSW	10	86,713,386 (GRCm38)	missense	possibly damaging	0.91
R2401:Ttc41	UTSW	10	86,724,374 (GRCm38)	missense	probably benign	0.42
R3117:Ttc41	UTSW	10	86,724,320 (GRCm38)	missense	possibly damaging	0.62
R3119:Ttc41	UTSW	10	86,724,320 (GRCm38)	missense	possibly damaging	0.62
R4805:Ttc41	UTSW	10	86,729,798 (GRCm38)	missense	possibly damaging	0.62
R4840:Ttc41	UTSW	10	86,731,125 (GRCm38)	missense	probably benign	0.10
R4841:Ttc41	UTSW	10	86,731,125 (GRCm38)	missense	probably benign	0.10
R4842:Ttc41	UTSW	10	86,731,125 (GRCm38)	missense	probably benign	0.10
R4884:Ttc41	UTSW	10	86,731,018 (GRCm38)	missense	probably benign	0.00
R4885:Ttc41	UTSW	10	86,759,102 (GRCm38)	missense	possibly damaging	0.76
R4898:Ttc41	UTSW	10	86,776,192 (GRCm38)	missense	possibly damaging	0.80
R5067:Ttc41	UTSW	10	86,744,544 (GRCm38)	missense	probably damaging	0.96
R5253:Ttc41	UTSW	10	86,730,942 (GRCm38)	missense	probably benign	0.13
R5268:Ttc41	UTSW	10	86,744,478 (GRCm38)	missense	possibly damaging	0.76
R5297:Ttc41	UTSW	10	86,776,579 (GRCm38)	missense	probably benign	0.04
R5301:Ttc41	UTSW	10	86,719,520 (GRCm38)	missense	probably benign	0.00
R5425:Ttc41	UTSW	10	86,776,630 (GRCm38)	missense	probably damaging	0.96
R5567:Ttc41	UTSW	10	86,760,920 (GRCm38)	critical splice donor site	probably null
R5635:Ttc41	UTSW	10	86,736,977 (GRCm38)	missense	probably benign	0.09
R5752:Ttc41	UTSW	10	86,758,346 (GRCm38)	missense	probably benign	0.33
R5868:Ttc41	UTSW	10	86,750,264 (GRCm38)	missense	possibly damaging	0.70
R5948:Ttc41	UTSW	10	86,713,224 (GRCm38)	missense	probably damaging	1.00
R6116:Ttc41	UTSW	10	86,759,088 (GRCm38)	critical splice acceptor site	probably null
R6247:Ttc41	UTSW	10	86,776,663 (GRCm38)	missense	probably benign	0.00
R6260:Ttc41	UTSW	10	86,733,707 (GRCm38)	missense	probably benign	0.32
R6260:Ttc41	UTSW	10	86,731,159 (GRCm38)	missense	probably benign	0.20
R6276:Ttc41	UTSW	10	86,744,449 (GRCm38)	missense	probably benign	0.01
R6458:Ttc41	UTSW	10	86,758,270 (GRCm38)	missense	possibly damaging	0.45
R7170:Ttc41	UTSW	10	86,713,503 (GRCm38)	missense	probably benign	0.17
R7348:Ttc41	UTSW	10	86,750,348 (GRCm38)	nonsense	probably null
R7382:Ttc41	UTSW	10	86,776,510 (GRCm38)	missense	probably damaging	0.97
R7509:Ttc41	UTSW	10	86,713,432 (GRCm38)	missense	probably damaging	1.00
R7689:Ttc41	UTSW	10	86,759,224 (GRCm38)	missense	probably damaging	1.00
R7807:Ttc41	UTSW	10	86,776,631 (GRCm38)	missense	probably benign	0.02
R7926:Ttc41	UTSW	10	86,776,047 (GRCm38)	missense	probably benign	0.10
R7998:Ttc41	UTSW	10	86,736,847 (GRCm38)	missense	probably benign	0.01
R8021:Ttc41	UTSW	10	86,733,714 (GRCm38)	missense	probably benign
R8059:Ttc41	UTSW	10	86,712,978 (GRCm38)	missense	probably benign	0.01
R8170:Ttc41	UTSW	10	86,776,166 (GRCm38)	missense	probably damaging	1.00
R8303:Ttc41	UTSW	10	86,719,630 (GRCm38)	missense	probably benign	0.06
R8375:Ttc41	UTSW	10	86,763,980 (GRCm38)	missense	probably damaging	0.97
R8383:Ttc41	UTSW	10	86,719,526 (GRCm38)	missense	probably benign	0.00
R8698:Ttc41	UTSW	10	86,712,977 (GRCm38)	missense	probably benign	0.00
R8773:Ttc41	UTSW	10	86,729,815 (GRCm38)	missense	probably benign	0.35
R8902:Ttc41	UTSW	10	86,713,001 (GRCm38)	missense	probably benign	0.06
R8985:Ttc41	UTSW	10	86,731,092 (GRCm38)	missense	possibly damaging	0.80
R8988:Ttc41	UTSW	10	86,713,735 (GRCm38)	missense	possibly damaging	0.88
R9007:Ttc41	UTSW	10	86,733,761 (GRCm38)	missense	probably damaging	1.00
R9137:Ttc41	UTSW	10	86,776,622 (GRCm38)	missense	probably benign	0.22
R9236:Ttc41	UTSW	10	86,776,730 (GRCm38)	missense	probably damaging	1.00
R9248:Ttc41	UTSW	10	86,731,249 (GRCm38)	missense	probably benign	0.00
R9287:Ttc41	UTSW	10	86,763,966 (GRCm38)	missense	probably benign	0.43
R9345:Ttc41	UTSW	10	86,759,225 (GRCm38)	missense	probably damaging	0.99
R9386:Ttc41	UTSW	10	86,713,026 (GRCm38)	missense	probably damaging	0.99
R9500:Ttc41	UTSW	10	86,729,862 (GRCm38)	missense	probably benign	0.03
R9570:Ttc41	UTSW	10	86,713,734 (GRCm38)	missense	possibly damaging	0.88
R9593:Ttc41	UTSW	10	86,713,185 (GRCm38)	missense	probably benign	0.24
X0024:Ttc41	UTSW	10	86,724,250 (GRCm38)	missense	probably damaging	1.00
X0064:Ttc41	UTSW	10	86,729,797 (GRCm38)	missense	probably benign	0.01

Posted On

2016-08-02