Incidental Mutation 'IGL03211:Wfdc10'
ID413304
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Wfdc10
Ensembl Gene ENSMUSG00000070529
Gene NameWAP four-disulfide core domain 10
SynonymsOTTMUSG00000016289
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.082) question?
Stock #IGL03211
Quality Score
Status
Chromosome2
Chromosomal Location164656046-164657368 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 164657252 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 94 (V94A)
Ref Sequence ENSEMBL: ENSMUSP00000091904 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094344] [ENSMUST00000109335]
Predicted Effect probably benign
Transcript: ENSMUST00000094344
AA Change: V94A

PolyPhen 2 Score 0.346 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000091904
Gene: ENSMUSG00000070529
AA Change: V94A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Blast:WAP 38 78 7e-10 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000109335
SMART Domains Protein: ENSMUSP00000104959
Gene: ENSMUSG00000074594

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Bmp7 C T 2: 172,872,883 V378I possibly damaging Het
Cd209b G T 8: 3,918,830 probably benign Het
Cilp A T 9: 65,280,175 Q1184L probably benign Het
Cysltr2 A T 14: 73,029,715 M185K possibly damaging Het
Dcaf6 A G 1: 165,422,933 F121L possibly damaging Het
Dnajc8 T A 4: 132,544,737 Y95N possibly damaging Het
Ebf3 A G 7: 137,231,304 V214A probably benign Het
Elavl3 A G 9: 22,018,678 V310A probably damaging Het
Emc2 C T 15: 43,507,672 R131* probably null Het
Hcn4 G A 9: 58,858,151 V639M unknown Het
Kif21a T G 15: 90,997,963 D46A possibly damaging Het
Kitl T C 10: 100,080,859 S175P probably benign Het
Klhl32 C T 4: 24,792,616 probably null Het
Plcg1 C T 2: 160,759,691 T972I possibly damaging Het
Prdm13 T C 4: 21,678,492 H666R probably damaging Het
Rap1gap G A 4: 137,715,846 probably null Het
Rdh7 T C 10: 127,887,623 N121S probably benign Het
Ric8b T A 10: 85,001,793 I488N probably damaging Het
Slc38a2 A T 15: 96,698,272 probably null Het
Slc9a9 G A 9: 95,137,990 probably benign Het
Tk2 T A 8: 104,243,441 I64F probably damaging Het
Virma G A 4: 11,548,770 W1776* probably null Het
Vrk1 C T 12: 106,036,588 A15V probably benign Het
Wdfy3 T C 5: 101,844,912 probably benign Het
Zfp780b A T 7: 27,963,175 C652S possibly damaging Het
Other mutations in Wfdc10
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5127:Wfdc10 UTSW 2 164657140 nonsense probably null
Posted On2016-08-02