Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03211:Wfdc10'

413304

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Wfdc10

Ensembl Gene

ENSMUSG00000070529

Gene Name

WAP four-disulfide core domain 10

Synonyms

OTTMUSG00000016289

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.155) question?

Stock #

IGL03211

Quality Score

Status

Chromosome

Chromosomal Location

164497966-164499288 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 164499172 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 94 (V94A)

Ref Sequence

ENSEMBL: ENSMUSP00000091904 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094344] [ENSMUST00000109335]

AlphaFold

Q3V2J9

Predicted Effect

probably benign
Transcript: ENSMUST00000094344
AA Change: V94A

PolyPhen 2 Score 0.346 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000091904
Gene: ENSMUSG00000070529
AA Change: V94A

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Blast:WAP	38	78	7e-10	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000109335

SMART Domains

Protein: ENSMUSP00000104959
Gene: ENSMUSG00000074594

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 25 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bmp7	C	T	2: 172,714,676 (GRCm39)	V378I	possibly damaging	Het
Cd209b	G	T	8: 3,968,830 (GRCm39)		probably benign	Het
Cilp	A	T	9: 65,187,457 (GRCm39)	Q1184L	probably benign	Het
Cysltr2	A	T	14: 73,267,155 (GRCm39)	M185K	possibly damaging	Het
Dcaf6	A	G	1: 165,250,502 (GRCm39)	F121L	possibly damaging	Het
Dnajc8	T	A	4: 132,272,048 (GRCm39)	Y95N	possibly damaging	Het
Ebf3	A	G	7: 136,833,033 (GRCm39)	V214A	probably benign	Het
Elavl3	A	G	9: 21,929,974 (GRCm39)	V310A	probably damaging	Het
Emc2	C	T	15: 43,371,068 (GRCm39)	R131*	probably null	Het
Hcn4	G	A	9: 58,765,434 (GRCm39)	V639M	unknown	Het
Kif21a	T	G	15: 90,882,166 (GRCm39)	D46A	possibly damaging	Het
Kitl	T	C	10: 99,916,721 (GRCm39)	S175P	probably benign	Het
Klhl32	C	T	4: 24,792,616 (GRCm39)		probably null	Het
Plcg1	C	T	2: 160,601,611 (GRCm39)	T972I	possibly damaging	Het
Prdm13	T	C	4: 21,678,492 (GRCm39)	H666R	probably damaging	Het
Rap1gap	G	A	4: 137,443,157 (GRCm39)		probably null	Het
Rdh7	T	C	10: 127,723,492 (GRCm39)	N121S	probably benign	Het
Ric8b	T	A	10: 84,837,657 (GRCm39)	I488N	probably damaging	Het
Slc38a2	A	T	15: 96,596,153 (GRCm39)		probably null	Het
Slc9a9	G	A	9: 95,020,043 (GRCm39)		probably benign	Het
Tk2	T	A	8: 104,970,073 (GRCm39)	I64F	probably damaging	Het
Virma	G	A	4: 11,548,770 (GRCm39)	W1776*	probably null	Het
Vrk1	C	T	12: 106,002,847 (GRCm39)	A15V	probably benign	Het
Wdfy3	T	C	5: 101,992,778 (GRCm39)		probably benign	Het
Zfp780b	A	T	7: 27,662,600 (GRCm39)	C652S	possibly damaging	Het

Other mutations in Wfdc10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R5127:Wfdc10	UTSW	2	164,499,060 (GRCm39)	nonsense	probably null
R8465:Wfdc10	UTSW	2	164,499,180 (GRCm39)	missense	possibly damaging	0.79

Posted On

2016-08-02