Incidental Mutation 'IGL03211:Cd209b'
| ID |
413317 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Cd209b
|
| Ensembl Gene |
ENSMUSG00000065987 |
| Gene Name |
CD209b antigen |
| Synonyms |
1810030I22Rik, mSIGNR1, SIGNR1 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.055)
|
| Stock # |
IGL03211
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
8 |
| Chromosomal Location |
3967655-3976841 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
G to T
at 3968830 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140695
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084086]
[ENSMUST00000111014]
[ENSMUST00000171635]
[ENSMUST00000188386]
|
| AlphaFold |
Q8CJ91 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084086
|
| SMART Domains |
Protein: ENSMUSP00000081104
Gene: ENSMUSG00000065987
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
53 |
75 |
N/A |
INTRINSIC |
|
low complexity region
|
91 |
102 |
N/A |
INTRINSIC |
|
CLECT
|
195 |
316 |
3.63e-31 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000111014
|
| SMART Domains |
Protein: ENSMUSP00000106643
Gene: ENSMUSG00000065987
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
61 |
72 |
N/A |
INTRINSIC |
|
CLECT
|
165 |
307 |
2.43e-23 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171635
|
| SMART Domains |
Protein: ENSMUSP00000126070
Gene: ENSMUSG00000065987
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
61 |
72 |
N/A |
INTRINSIC |
|
CLECT
|
165 |
286 |
3.63e-31 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188386
|
| SMART Domains |
Protein: ENSMUSP00000140695
Gene: ENSMUSG00000065987
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
61 |
72 |
N/A |
INTRINSIC |
|
CLECT
|
165 |
307 |
2.43e-23 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous mutants are more susceptible to S. pneumoniae infection and fail to clear the bacteria from the circulation. Marginal zone and peritoneal macrophages are impaired in recognizing the bacteria. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bmp7 |
C |
T |
2: 172,714,676 (GRCm39) |
V378I |
possibly damaging |
Het |
| Cilp |
A |
T |
9: 65,187,457 (GRCm39) |
Q1184L |
probably benign |
Het |
| Cysltr2 |
A |
T |
14: 73,267,155 (GRCm39) |
M185K |
possibly damaging |
Het |
| Dcaf6 |
A |
G |
1: 165,250,502 (GRCm39) |
F121L |
possibly damaging |
Het |
| Dnajc8 |
T |
A |
4: 132,272,048 (GRCm39) |
Y95N |
possibly damaging |
Het |
| Ebf3 |
A |
G |
7: 136,833,033 (GRCm39) |
V214A |
probably benign |
Het |
| Elavl3 |
A |
G |
9: 21,929,974 (GRCm39) |
V310A |
probably damaging |
Het |
| Emc2 |
C |
T |
15: 43,371,068 (GRCm39) |
R131* |
probably null |
Het |
| Hcn4 |
G |
A |
9: 58,765,434 (GRCm39) |
V639M |
unknown |
Het |
| Kif21a |
T |
G |
15: 90,882,166 (GRCm39) |
D46A |
possibly damaging |
Het |
| Kitl |
T |
C |
10: 99,916,721 (GRCm39) |
S175P |
probably benign |
Het |
| Klhl32 |
C |
T |
4: 24,792,616 (GRCm39) |
|
probably null |
Het |
| Plcg1 |
C |
T |
2: 160,601,611 (GRCm39) |
T972I |
possibly damaging |
Het |
| Prdm13 |
T |
C |
4: 21,678,492 (GRCm39) |
H666R |
probably damaging |
Het |
| Rap1gap |
G |
A |
4: 137,443,157 (GRCm39) |
|
probably null |
Het |
| Rdh7 |
T |
C |
10: 127,723,492 (GRCm39) |
N121S |
probably benign |
Het |
| Ric8b |
T |
A |
10: 84,837,657 (GRCm39) |
I488N |
probably damaging |
Het |
| Slc38a2 |
A |
T |
15: 96,596,153 (GRCm39) |
|
probably null |
Het |
| Slc9a9 |
G |
A |
9: 95,020,043 (GRCm39) |
|
probably benign |
Het |
| Tk2 |
T |
A |
8: 104,970,073 (GRCm39) |
I64F |
probably damaging |
Het |
| Virma |
G |
A |
4: 11,548,770 (GRCm39) |
W1776* |
probably null |
Het |
| Vrk1 |
C |
T |
12: 106,002,847 (GRCm39) |
A15V |
probably benign |
Het |
| Wdfy3 |
T |
C |
5: 101,992,778 (GRCm39) |
|
probably benign |
Het |
| Wfdc10 |
T |
C |
2: 164,499,172 (GRCm39) |
V94A |
probably benign |
Het |
| Zfp780b |
A |
T |
7: 27,662,600 (GRCm39) |
C652S |
possibly damaging |
Het |
|
| Other mutations in Cd209b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00155:Cd209b
|
APN |
8 |
3,969,945 (GRCm39) |
splice site |
probably benign |
|
|
IGL01596:Cd209b
|
APN |
8 |
3,968,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1434:Cd209b
|
UTSW |
8 |
3,973,367 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4127:Cd209b
|
UTSW |
8 |
3,968,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4387:Cd209b
|
UTSW |
8 |
3,975,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4388:Cd209b
|
UTSW |
8 |
3,975,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4389:Cd209b
|
UTSW |
8 |
3,975,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4708:Cd209b
|
UTSW |
8 |
3,974,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4710:Cd209b
|
UTSW |
8 |
3,974,215 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4911:Cd209b
|
UTSW |
8 |
3,976,640 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5454:Cd209b
|
UTSW |
8 |
3,975,396 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5814:Cd209b
|
UTSW |
8 |
3,973,348 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5853:Cd209b
|
UTSW |
8 |
3,976,549 (GRCm39) |
splice site |
probably null |
|
|
R5867:Cd209b
|
UTSW |
8 |
3,974,246 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R5996:Cd209b
|
UTSW |
8 |
3,968,688 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7020:Cd209b
|
UTSW |
8 |
3,968,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7187:Cd209b
|
UTSW |
8 |
3,976,638 (GRCm39) |
missense |
probably benign |
|
|
R7695:Cd209b
|
UTSW |
8 |
3,976,005 (GRCm39) |
missense |
probably benign |
|
|
R7712:Cd209b
|
UTSW |
8 |
3,973,299 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7975:Cd209b
|
UTSW |
8 |
3,975,948 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8309:Cd209b
|
UTSW |
8 |
3,976,559 (GRCm39) |
nonsense |
probably null |
|
|
R8317:Cd209b
|
UTSW |
8 |
3,972,018 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9159:Cd209b
|
UTSW |
8 |
3,974,245 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9214:Cd209b
|
UTSW |
8 |
3,968,771 (GRCm39) |
missense |
probably benign |
0.22 |
|
| Posted On |
2016-08-02 |
Incidental Mutation