Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03212:Vmn2r52'

413330

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r52

Ensembl Gene

ENSMUSG00000091930

Gene Name

vomeronasal 2, receptor 52

Synonyms

EG384534

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.065) question?

Stock #

IGL03212

Quality Score

Status

Chromosome

Chromosomal Location

9892579-9910213 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 9893474 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Proline at position 555 (H555P)

Ref Sequence

ENSEMBL: ENSMUSP00000129352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164918]

AlphaFold

L7N2B2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164918
AA Change: H555P

PolyPhen 2 Score 0.465 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000129352
Gene: ENSMUSG00000091930
AA Change: H555P

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	8.1e-29	PFAM
Pfam:NCD3G	512	565	1.5e-19	PFAM
Pfam:7tm_3	596	833	1.1e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 35 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Als2	A	G	1: 59,242,085 (GRCm39)	S657P	probably benign	Het
Atp2c1	T	A	9: 105,322,466 (GRCm39)	N221I	probably damaging	Het
Atp5pd	G	T	11: 115,306,597 (GRCm39)	H155N	probably damaging	Het
Cd55b	A	T	1: 130,339,179 (GRCm39)	N316K	probably benign	Het
Celsr1	A	T	15: 85,814,878 (GRCm39)	M1861K	probably benign	Het
Cfap69	T	G	5: 5,707,849 (GRCm39)		probably null	Het
Col7a1	C	A	9: 108,803,520 (GRCm39)	P2169Q	unknown	Het
Cyp2j5	G	T	4: 96,552,055 (GRCm39)	H65N	probably damaging	Het
Dnah5	T	C	15: 28,290,309 (GRCm39)	V1233A	probably benign	Het
Fn1	A	T	1: 71,680,484 (GRCm39)	L407*	probably null	Het
Fpr-rs3	T	C	17: 20,844,121 (GRCm39)	D340G	probably benign	Het
Fut2	C	T	7: 45,300,193 (GRCm39)	G193E	possibly damaging	Het
Glmp	T	C	3: 88,235,664 (GRCm39)	S317P	probably benign	Het
Gm5581	A	T	6: 131,158,413 (GRCm39)		noncoding transcript	Het
Gm5624	A	T	14: 44,798,167 (GRCm39)	N103K	probably benign	Het
Gprin3	A	G	6: 59,332,013 (GRCm39)	F98S	probably benign	Het
Ighmbp2	A	G	19: 3,329,942 (GRCm39)	V104A	probably damaging	Het
Igkv4-79	A	C	6: 69,020,214 (GRCm39)	S34A	probably benign	Het
Igsf10	G	A	3: 59,235,586 (GRCm39)	P1532S	probably benign	Het
Myt1l	A	G	12: 29,877,819 (GRCm39)	K490R	unknown	Het
Or5d46	T	A	2: 88,170,016 (GRCm39)	Y36N	probably damaging	Het
Pira13	T	A	7: 3,826,132 (GRCm39)	Q287L	probably benign	Het
Plxna1	T	A	6: 89,308,885 (GRCm39)	T1198S	probably damaging	Het
Pramel6	A	G	2: 87,340,769 (GRCm39)	D367G	probably damaging	Het
Rbm28	G	T	6: 29,131,274 (GRCm39)	R10S	probably damaging	Het
Rdh10	T	G	1: 16,178,051 (GRCm39)	C108G	probably benign	Het
Rfx7	C	A	9: 72,526,443 (GRCm39)	T1211K	probably benign	Het
Slc24a5	C	A	2: 124,922,750 (GRCm39)	T141N	probably damaging	Het
Smarca5	T	A	8: 81,438,410 (GRCm39)	N642I	possibly damaging	Het
Smchd1	C	A	17: 71,750,886 (GRCm39)	R344L	probably damaging	Het
Tmx3	T	A	18: 90,556,642 (GRCm39)	I355N	probably damaging	Het
Tram1l1	G	A	3: 124,115,563 (GRCm39)	G241D	possibly damaging	Het
Ubr4	A	G	4: 139,137,074 (GRCm39)	T982A	probably benign	Het
Zbtb43	A	T	2: 33,344,286 (GRCm39)	M313K	probably benign	Het
Zfp942	A	T	17: 22,148,445 (GRCm39)	Y61*	probably null	Het

Other mutations in Vmn2r52

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00088:Vmn2r52	APN	7	9,903,023 (GRCm39)	missense	probably benign	0.30
IGL00328:Vmn2r52	APN	7	9,905,344 (GRCm39)	missense	probably benign	0.12
IGL00980:Vmn2r52	APN	7	9,905,017 (GRCm39)	missense	probably damaging	1.00
IGL01468:Vmn2r52	APN	7	9,892,868 (GRCm39)	missense	probably damaging	1.00
IGL01660:Vmn2r52	APN	7	9,893,107 (GRCm39)	missense	probably damaging	0.97
IGL02215:Vmn2r52	APN	7	9,905,029 (GRCm39)	missense	probably damaging	0.97
IGL03030:Vmn2r52	APN	7	9,892,799 (GRCm39)	missense	probably benign	0.12
FR4589:Vmn2r52	UTSW	7	9,892,947 (GRCm39)	missense	probably damaging	0.97
PIT4283001:Vmn2r52	UTSW	7	9,904,756 (GRCm39)	missense	possibly damaging	0.89
R0184:Vmn2r52	UTSW	7	9,893,265 (GRCm39)	missense	probably damaging	1.00
R0190:Vmn2r52	UTSW	7	9,905,315 (GRCm39)	missense	probably benign	0.00
R0240:Vmn2r52	UTSW	7	9,893,327 (GRCm39)	missense	probably damaging	0.99
R0240:Vmn2r52	UTSW	7	9,893,327 (GRCm39)	missense	probably damaging	0.99
R0257:Vmn2r52	UTSW	7	9,904,982 (GRCm39)	nonsense	probably null
R0310:Vmn2r52	UTSW	7	9,893,393 (GRCm39)	missense	probably damaging	1.00
R1831:Vmn2r52	UTSW	7	9,893,415 (GRCm39)	missense	probably damaging	1.00
R1862:Vmn2r52	UTSW	7	9,907,333 (GRCm39)	missense	possibly damaging	0.94
R2484:Vmn2r52	UTSW	7	9,903,058 (GRCm39)	missense	probably damaging	0.96
R2510:Vmn2r52	UTSW	7	9,904,795 (GRCm39)	missense	probably benign
R3625:Vmn2r52	UTSW	7	9,893,105 (GRCm39)	missense	probably damaging	1.00
R3803:Vmn2r52	UTSW	7	9,907,439 (GRCm39)	missense	probably damaging	1.00
R4013:Vmn2r52	UTSW	7	9,904,603 (GRCm39)	missense	probably benign	0.00
R4283:Vmn2r52	UTSW	7	9,904,565 (GRCm39)	missense	possibly damaging	0.60
R4324:Vmn2r52	UTSW	7	9,904,940 (GRCm39)	missense	possibly damaging	0.94
R4578:Vmn2r52	UTSW	7	9,904,617 (GRCm39)	missense	probably damaging	1.00
R4806:Vmn2r52	UTSW	7	9,893,169 (GRCm39)	missense	probably damaging	1.00
R5083:Vmn2r52	UTSW	7	9,893,392 (GRCm39)	nonsense	probably null
R5249:Vmn2r52	UTSW	7	9,910,197 (GRCm39)	missense	probably benign
R5306:Vmn2r52	UTSW	7	9,904,672 (GRCm39)	missense	possibly damaging	0.88
R5332:Vmn2r52	UTSW	7	9,903,052 (GRCm39)	missense	probably benign	0.17
R5617:Vmn2r52	UTSW	7	9,904,861 (GRCm39)	missense	probably damaging	0.99
R5643:Vmn2r52	UTSW	7	9,905,059 (GRCm39)	missense	probably damaging	1.00
R5749:Vmn2r52	UTSW	7	9,892,959 (GRCm39)	missense	probably damaging	1.00
R5763:Vmn2r52	UTSW	7	9,905,231 (GRCm39)	missense	probably benign	0.01
R6103:Vmn2r52	UTSW	7	9,905,327 (GRCm39)	missense	probably benign	0.36
R6148:Vmn2r52	UTSW	7	9,905,090 (GRCm39)	missense	probably benign	0.00
R6356:Vmn2r52	UTSW	7	9,902,926 (GRCm39)	missense	probably benign	0.01
R6412:Vmn2r52	UTSW	7	9,904,936 (GRCm39)	missense	probably benign
R6657:Vmn2r52	UTSW	7	9,893,090 (GRCm39)	missense	probably damaging	0.99
R6997:Vmn2r52	UTSW	7	9,902,998 (GRCm39)	missense	probably benign	0.06
R7395:Vmn2r52	UTSW	7	9,904,744 (GRCm39)	missense	probably benign	0.00
R7621:Vmn2r52	UTSW	7	9,907,274 (GRCm39)	missense	probably benign	0.00
R7691:Vmn2r52	UTSW	7	9,893,109 (GRCm39)	missense	probably damaging	0.97
R7852:Vmn2r52	UTSW	7	9,892,895 (GRCm39)	missense	probably damaging	1.00
R7908:Vmn2r52	UTSW	7	9,896,877 (GRCm39)	missense	probably benign
R7909:Vmn2r52	UTSW	7	9,896,877 (GRCm39)	missense	probably benign
R7912:Vmn2r52	UTSW	7	9,896,877 (GRCm39)	missense	probably benign
R7913:Vmn2r52	UTSW	7	9,896,877 (GRCm39)	missense	probably benign
R7938:Vmn2r52	UTSW	7	9,893,300 (GRCm39)	missense	probably benign	0.12
R8884:Vmn2r52	UTSW	7	9,892,734 (GRCm39)	missense	probably damaging	1.00
R9003:Vmn2r52	UTSW	7	9,905,181 (GRCm39)	missense	probably benign	0.07
R9140:Vmn2r52	UTSW	7	9,892,643 (GRCm39)	missense	probably damaging	0.99
R9141:Vmn2r52	UTSW	7	9,905,331 (GRCm39)	nonsense	probably null
R9500:Vmn2r52	UTSW	7	9,905,281 (GRCm39)	missense	probably damaging	1.00
R9562:Vmn2r52	UTSW	7	9,893,476 (GRCm39)	missense	probably benign	0.22
R9564:Vmn2r52	UTSW	7	9,905,182 (GRCm39)	missense	probably benign	0.15
R9565:Vmn2r52	UTSW	7	9,893,476 (GRCm39)	missense	probably benign	0.22
R9597:Vmn2r52	UTSW	7	9,904,719 (GRCm39)	nonsense	probably null
R9743:Vmn2r52	UTSW	7	9,904,606 (GRCm39)	missense	possibly damaging	0.81
Z1176:Vmn2r52	UTSW	7	9,905,127 (GRCm39)	missense	probably damaging	0.97
Z1177:Vmn2r52	UTSW	7	9,903,117 (GRCm39)	missense	possibly damaging	0.93

Posted On

2016-08-02