Incidental Mutation 'IGL03214:Olfr31'
ID413415
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr31
Ensembl Gene ENSMUSG00000072707
Gene Nameolfactory receptor 31
SynonymsMOR274-1, GA_x6K02T2PLTE-6714644-6715597, MTPCR53
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.276) question?
Stock #IGL03214
Quality Score
Status
Chromosome14
Chromosomal Location14322828-14331791 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 14328284 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 58 (M58L)
Ref Sequence ENSEMBL: ENSMUSP00000149019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100872] [ENSMUST00000206009] [ENSMUST00000217035]
Predicted Effect probably damaging
Transcript: ENSMUST00000100872
AA Change: M58L

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000098434
Gene: ENSMUSG00000072707
AA Change: M58L

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 5.7e-50 PFAM
Pfam:7tm_1 40 289 3.1e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000206009
AA Change: M58L

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000217035
AA Change: M58L

PolyPhen 2 Score 0.983 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224991
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy1 T C 11: 7,167,054 probably benign Het
Asb5 T C 8: 54,585,063 V207A probably benign Het
Atxn3 G T 12: 101,945,922 probably benign Het
Brwd1 T C 16: 96,037,900 D857G probably benign Het
Cacna1i A G 15: 80,355,716 N322S probably benign Het
Dcun1d1 A T 3: 35,919,071 W92R probably damaging Het
Dnah7a A C 1: 53,522,209 probably null Het
Enpep T C 3: 129,293,247 D581G probably benign Het
Fam135a G A 1: 24,053,276 L201F probably damaging Het
Gm14496 T G 2: 182,000,536 L667V probably damaging Het
Grk4 T A 5: 34,752,209 M539K probably benign Het
Itpr2 A G 6: 146,180,244 V2261A probably benign Het
Krtap5-2 A G 7: 142,175,014 S310P unknown Het
Mme A T 3: 63,329,690 Y232F possibly damaging Het
Mtmr4 T C 11: 87,597,693 Y58H probably damaging Het
Myh13 T C 11: 67,353,585 S983P possibly damaging Het
Nbas A G 12: 13,331,110 probably benign Het
Neb T A 2: 52,197,844 T5448S possibly damaging Het
Neb C T 2: 52,159,548 G6428R probably damaging Het
Olfr1156 T A 2: 87,950,071 Q54L probably benign Het
Olfr472 T C 7: 107,902,966 M83T probably benign Het
Olfr598 G T 7: 103,328,666 S60I possibly damaging Het
Olfr699 T A 7: 106,790,345 I219L probably benign Het
Otx2 A G 14: 48,661,324 I75T probably damaging Het
Phex A T X: 157,177,504 N681K probably damaging Het
Plekha8 C A 6: 54,635,770 A454E probably damaging Het
Rbfa C A 18: 80,197,291 K152N probably benign Het
Satb2 C A 1: 56,845,580 S513I probably damaging Het
Slc4a2 G T 5: 24,434,881 R520L probably benign Het
Slfn14 T C 11: 83,279,000 H606R probably benign Het
Smc1b G A 15: 85,097,946 Q716* probably null Het
Syncrip C T 9: 88,464,643 probably benign Het
Vmn2r30 T A 7: 7,334,260 I126F probably benign Het
Vps13c C T 9: 67,897,195 A762V probably null Het
Wdr64 C A 1: 175,743,635 probably benign Het
Wisp3 T C 10: 39,153,167 N255S probably benign Het
Other mutations in Olfr31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02550:Olfr31 APN 14 14328423 missense possibly damaging 0.91
IGL02566:Olfr31 APN 14 14328138 missense probably benign 0.05
IGL02902:Olfr31 APN 14 14328789 missense probably benign
IGL03106:Olfr31 APN 14 14328851 missense probably damaging 0.97
R0333:Olfr31 UTSW 14 14328498 missense probably damaging 1.00
R0828:Olfr31 UTSW 14 14328800 missense probably benign 0.00
R1231:Olfr31 UTSW 14 14328515 missense probably benign 0.00
R1725:Olfr31 UTSW 14 14328977 missense probably damaging 1.00
R1823:Olfr31 UTSW 14 14328774 missense probably damaging 1.00
R1824:Olfr31 UTSW 14 14328774 missense probably damaging 1.00
R2026:Olfr31 UTSW 14 14328891 missense probably benign 0.10
R3891:Olfr31 UTSW 14 14328114 start codon destroyed probably null 0.99
R4327:Olfr31 UTSW 14 14328193 missense probably damaging 1.00
R4328:Olfr31 UTSW 14 14328193 missense probably damaging 1.00
R4608:Olfr31 UTSW 14 14328887 missense probably benign 0.06
R4893:Olfr31 UTSW 14 14328852 missense probably damaging 1.00
R5197:Olfr31 UTSW 14 14328462 missense probably damaging 1.00
R5402:Olfr31 UTSW 14 14328878 missense probably damaging 1.00
R5787:Olfr31 UTSW 14 14328725 missense probably damaging 0.98
R5897:Olfr31 UTSW 14 14328120 missense probably benign 0.00
R7340:Olfr31 UTSW 14 14328401 missense possibly damaging 0.90
R7709:Olfr31 UTSW 14 14328384 missense probably damaging 1.00
Posted On2016-08-02