Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03216:Cage1'

413496

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cage1

Ensembl Gene

ENSMUSG00000044566

Gene Name

cancer antigen 1

Synonyms

Ctag3, CAGE1, 4933427I01Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

IGL03216

Quality Score

Status

Chromosome

Chromosomal Location

38190028-38221045 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 38190153 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000105862 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074969] [ENSMUST00000110233]

AlphaFold

Q5IR70

Predicted Effect

probably benign
Transcript: ENSMUST00000074969

SMART Domains

Protein: ENSMUSP00000074499
Gene: ENSMUSG00000044566

Domain	Start	End	E-Value	Type
Pfam:CAGE1	1	526	5.1e-292	PFAM
low complexity region	664	682	N/A	INTRINSIC
coiled coil region	778	811	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000110233

SMART Domains

Protein: ENSMUSP00000105862
Gene: ENSMUSG00000044566

Domain	Start	End	E-Value	Type
Pfam:CAGE1	1	526	2.4e-255	PFAM
low complexity region	664	682	N/A	INTRINSIC
coiled coil region	778	811	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ano10	A	T	9: 122,086,127 (GRCm39)	Y491N	probably damaging	Het
Cacna2d1	T	C	5: 16,558,840 (GRCm39)	F709L	probably damaging	Het
Cadps	A	G	14: 12,439,944 (GRCm38)	I1196T	probably damaging	Het
Cep350	A	T	1: 155,736,373 (GRCm39)	C2888S	probably benign	Het
Cfap52	T	C	11: 67,844,932 (GRCm39)	T46A	possibly damaging	Het
Cyp2d26	T	C	15: 82,677,462 (GRCm39)	M76V	probably benign	Het
Fermt3	A	T	19: 6,976,748 (GRCm39)	D653E	probably benign	Het
Foxj3	A	G	4: 119,467,180 (GRCm39)		probably benign	Het
Gm21985	T	A	2: 112,097,281 (GRCm39)	S39T	probably damaging	Het
Herc1	A	T	9: 66,386,228 (GRCm39)	D3727V	probably benign	Het
Ifi208	A	T	1: 173,506,507 (GRCm39)	T97S	possibly damaging	Het
Iqgap1	T	C	7: 80,392,836 (GRCm39)	E709G	probably benign	Het
Itgb5	T	A	16: 33,723,208 (GRCm39)	H361Q	probably benign	Het
Mr1	T	A	1: 155,005,035 (GRCm39)	N335I	possibly damaging	Het
Nadsyn1	A	T	7: 143,351,582 (GRCm39)	F684I	probably damaging	Het
Nf1	A	T	11: 79,455,721 (GRCm39)	I2544F	probably benign	Het
Or6c1b	A	G	10: 129,272,806 (GRCm39)	T42A	probably damaging	Het
Pnp2	T	G	14: 51,200,654 (GRCm39)	S107A	probably benign	Het
Pomt1	A	G	2: 32,132,955 (GRCm39)	I184V	probably damaging	Het
Slc6a19	T	G	13: 73,834,300 (GRCm39)	M301L	probably benign	Het
Smarca5	T	C	8: 81,446,287 (GRCm39)	Y471C	probably damaging	Het
Syne2	A	T	12: 75,989,735 (GRCm39)		probably benign	Het
Tasor2	C	T	13: 3,624,553 (GRCm39)	C1799Y	probably damaging	Het
Tex55	T	C	16: 38,649,052 (GRCm39)	D19G	possibly damaging	Het
Trmt6	T	C	2: 132,650,618 (GRCm39)	N330S	probably null	Het
Tsc22d1	T	C	14: 76,656,077 (GRCm39)	V770A	probably benign	Het
Ttll6	A	G	11: 96,042,840 (GRCm39)	D462G	probably benign	Het
Ttn	T	C	2: 76,775,393 (GRCm39)	H1883R	probably damaging	Het
Ubxn10	C	T	4: 138,448,050 (GRCm39)	V209M	probably damaging	Het
Urb1	T	C	16: 90,585,002 (GRCm39)	T540A	probably benign	Het
Vmn2r17	A	T	5: 109,600,756 (GRCm39)	R685W	probably damaging	Het
Vps4a	C	T	8: 107,763,335 (GRCm39)	R30C	probably damaging	Het
Xpo6	A	G	7: 125,703,985 (GRCm39)	V1055A	probably damaging	Het
Zfp445	C	T	9: 122,681,043 (GRCm39)	C966Y	probably damaging	Het

Other mutations in Cage1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00648:Cage1	APN	13	38,206,969 (GRCm39)	nonsense	probably null
IGL01736:Cage1	APN	13	38,206,789 (GRCm39)	missense	possibly damaging	0.93
IGL02149:Cage1	APN	13	38,206,505 (GRCm39)	missense	probably damaging	1.00
IGL02267:Cage1	APN	13	38,207,233 (GRCm39)	missense	probably damaging	1.00
IGL03030:Cage1	APN	13	38,212,123 (GRCm39)	missense	probably benign
R0487:Cage1	UTSW	13	38,209,334 (GRCm39)	missense	probably benign	0.00
R0606:Cage1	UTSW	13	38,200,470 (GRCm39)	splice site	probably benign
R1015:Cage1	UTSW	13	38,200,451 (GRCm39)	missense	possibly damaging	0.96
R1170:Cage1	UTSW	13	38,206,856 (GRCm39)	missense	probably damaging	1.00
R1400:Cage1	UTSW	13	38,216,400 (GRCm39)	missense	possibly damaging	0.86
R1721:Cage1	UTSW	13	38,207,309 (GRCm39)	nonsense	probably null
R2057:Cage1	UTSW	13	38,207,356 (GRCm39)	missense	probably benign	0.04
R2058:Cage1	UTSW	13	38,207,356 (GRCm39)	missense	probably benign	0.04
R2059:Cage1	UTSW	13	38,207,356 (GRCm39)	missense	probably benign	0.04
R2197:Cage1	UTSW	13	38,207,029 (GRCm39)	missense	probably damaging	1.00
R3757:Cage1	UTSW	13	38,209,705 (GRCm39)	missense	possibly damaging	0.71
R3758:Cage1	UTSW	13	38,209,705 (GRCm39)	missense	possibly damaging	0.71
R4041:Cage1	UTSW	13	38,203,153 (GRCm39)	missense	possibly damaging	0.96
R4370:Cage1	UTSW	13	38,209,626 (GRCm39)	missense	probably damaging	1.00
R4401:Cage1	UTSW	13	38,207,078 (GRCm39)	missense	probably damaging	1.00
R4402:Cage1	UTSW	13	38,207,078 (GRCm39)	missense	probably damaging	1.00
R4403:Cage1	UTSW	13	38,207,078 (GRCm39)	missense	probably damaging	1.00
R4490:Cage1	UTSW	13	38,207,393 (GRCm39)	missense	possibly damaging	0.86
R4621:Cage1	UTSW	13	38,209,477 (GRCm39)	missense	possibly damaging	0.85
R4921:Cage1	UTSW	13	38,203,184 (GRCm39)	missense	probably benign	0.33
R4950:Cage1	UTSW	13	38,207,302 (GRCm39)	missense	possibly damaging	0.55
R4953:Cage1	UTSW	13	38,207,406 (GRCm39)	missense	possibly damaging	0.51
R5023:Cage1	UTSW	13	38,195,387 (GRCm39)	nonsense	probably null
R5808:Cage1	UTSW	13	38,206,301 (GRCm39)	unclassified	probably benign
R5845:Cage1	UTSW	13	38,199,682 (GRCm39)	missense	probably damaging	0.96
R6278:Cage1	UTSW	13	38,200,395 (GRCm39)	missense	possibly damaging	0.53
R6503:Cage1	UTSW	13	38,209,425 (GRCm39)	missense	possibly damaging	0.73
R6882:Cage1	UTSW	13	38,206,534 (GRCm39)	missense	probably damaging	1.00
R7146:Cage1	UTSW	13	38,207,025 (GRCm39)	missense	probably benign	0.03
R7192:Cage1	UTSW	13	38,203,220 (GRCm39)	missense	probably benign
R7529:Cage1	UTSW	13	38,209,731 (GRCm39)	missense	possibly damaging	0.71
R7580:Cage1	UTSW	13	38,206,700 (GRCm39)	missense	possibly damaging	0.90
R7646:Cage1	UTSW	13	38,206,823 (GRCm39)	missense	probably damaging	1.00
R7837:Cage1	UTSW	13	38,206,381 (GRCm39)	missense	not run
R8355:Cage1	UTSW	13	38,203,225 (GRCm39)	missense	probably damaging	0.99
R8435:Cage1	UTSW	13	38,203,161 (GRCm39)	missense	possibly damaging	0.73
R8466:Cage1	UTSW	13	38,206,987 (GRCm39)	missense	probably damaging	1.00
R9047:Cage1	UTSW	13	38,201,338 (GRCm39)	missense	possibly damaging	0.85
R9086:Cage1	UTSW	13	38,206,898 (GRCm39)	missense	probably damaging	1.00
R9146:Cage1	UTSW	13	38,207,005 (GRCm39)	missense	probably benign	0.16
R9442:Cage1	UTSW	13	38,196,447 (GRCm39)	missense	possibly damaging	0.72
R9587:Cage1	UTSW	13	38,207,233 (GRCm39)	missense	probably damaging	1.00
R9608:Cage1	UTSW	13	38,195,371 (GRCm39)	missense	possibly damaging	0.73
R9612:Cage1	UTSW	13	38,216,351 (GRCm39)	missense	probably damaging	0.99
R9630:Cage1	UTSW	13	38,206,855 (GRCm39)	missense	probably damaging	1.00
R9690:Cage1	UTSW	13	38,203,141 (GRCm39)	critical splice donor site	probably null
R9736:Cage1	UTSW	13	38,207,393 (GRCm39)	missense	probably damaging	0.99

Posted On

2016-08-02