Incidental Mutation 'IGL03217:Ccl4'
ID413508
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccl4
Ensembl Gene ENSMUSG00000018930
Gene Namechemokine (C-C motif) ligand 4
SynonymsAct-2, MIP-1B, MIP-1 beta, Scya4, AT744.1, Mip1b
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.115) question?
Stock #IGL03217
Quality Score
Status
Chromosome11
Chromosomal Location83662584-83664683 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 83662678 bp
ZygosityHeterozygous
Amino Acid Change Serine to Proline at position 6 (S6P)
Ref Sequence ENSEMBL: ENSMUSP00000019074 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019074]
Predicted Effect unknown
Transcript: ENSMUST00000019074
AA Change: S6P
SMART Domains Protein: ENSMUSP00000019074
Gene: ENSMUSG00000018930
AA Change: S6P

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
SCY 31 89 9.92e-32 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aaas A G 15: 102,349,995 I29T probably damaging Het
Adam2 G A 14: 66,034,813 P640L possibly damaging Het
Cd300lf T A 11: 115,124,291 T151S possibly damaging Het
Elk4 A G 1: 132,018,040 T219A probably benign Het
Eml1 G T 12: 108,534,942 E680D probably benign Het
Gm9755 T C 8: 67,514,383 noncoding transcript Het
Hmcn1 A T 1: 150,743,667 I1232N possibly damaging Het
Maml2 T C 9: 13,619,999 S170P probably damaging Het
Mettl16 T A 11: 74,817,703 M536K probably damaging Het
Nelfcd G A 2: 174,426,832 A559T possibly damaging Het
Nxf2 T C X: 134,955,532 I287V probably benign Het
Nyap2 A G 1: 81,087,322 D17G probably damaging Het
Pde6b T C 5: 108,419,566 C270R probably damaging Het
Ptchd1 T C X: 155,573,959 D750G probably damaging Het
Rrn3 G A 16: 13,809,011 E490K possibly damaging Het
Slc27a2 G A 2: 126,586,252 G519D possibly damaging Het
Sox5 A G 6: 143,907,497 S352P probably damaging Het
Spg20 G T 3: 55,128,491 probably benign Het
Sult1e1 T C 5: 87,590,088 T45A possibly damaging Het
Tat G A 8: 109,995,186 V242I probably benign Het
Zfp442 A G 2: 150,409,794 probably benign Het
Other mutations in Ccl4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0302:Ccl4 UTSW 11 83663454 splice site probably benign
R0328:Ccl4 UTSW 11 83663557 missense probably damaging 0.98
R1342:Ccl4 UTSW 11 83663576 splice site probably benign
R2894:Ccl4 UTSW 11 83663503 splice site probably null
R4934:Ccl4 UTSW 11 83662678 missense unknown
R6334:Ccl4 UTSW 11 83662678 missense unknown
Posted On2016-08-02